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Gene: STMN3 |
Gene summary for STMN3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | STMN3 | Gene ID | 50861 |
| Gene name | stathmin 3 | |
| Gene Alias | SCLIP | |
| Cytomap | 20q13.33 | |
| Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q9NZ72 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 50861 | STMN3 | LZE4T | Human | Esophagus | ESCC | 5.01e-03 | 2.36e-01 | 0.0811 |
| 50861 | STMN3 | LZE8T | Human | Esophagus | ESCC | 1.77e-02 | 1.56e-01 | 0.067 |
| 50861 | STMN3 | P2T-E | Human | Esophagus | ESCC | 6.96e-09 | 2.13e-01 | 0.1177 |
| 50861 | STMN3 | P4T-E | Human | Esophagus | ESCC | 2.06e-04 | 1.52e-01 | 0.1323 |
| 50861 | STMN3 | P9T-E | Human | Esophagus | ESCC | 1.37e-06 | 2.21e-01 | 0.1131 |
| 50861 | STMN3 | P10T-E | Human | Esophagus | ESCC | 1.29e-31 | 6.10e-01 | 0.116 |
| 50861 | STMN3 | P11T-E | Human | Esophagus | ESCC | 6.88e-05 | 3.18e-01 | 0.1426 |
| 50861 | STMN3 | P12T-E | Human | Esophagus | ESCC | 7.62e-48 | 8.30e-01 | 0.1122 |
| 50861 | STMN3 | P16T-E | Human | Esophagus | ESCC | 4.32e-54 | 1.20e+00 | 0.1153 |
| 50861 | STMN3 | P19T-E | Human | Esophagus | ESCC | 1.32e-10 | 6.77e-01 | 0.1662 |
| 50861 | STMN3 | P20T-E | Human | Esophagus | ESCC | 3.93e-25 | 6.91e-01 | 0.1124 |
| 50861 | STMN3 | P21T-E | Human | Esophagus | ESCC | 1.60e-13 | 3.23e-01 | 0.1617 |
| 50861 | STMN3 | P22T-E | Human | Esophagus | ESCC | 1.18e-11 | 3.17e-01 | 0.1236 |
| 50861 | STMN3 | P23T-E | Human | Esophagus | ESCC | 2.48e-03 | 1.56e-01 | 0.108 |
| 50861 | STMN3 | P24T-E | Human | Esophagus | ESCC | 2.74e-14 | 3.86e-01 | 0.1287 |
| 50861 | STMN3 | P26T-E | Human | Esophagus | ESCC | 1.09e-14 | 3.09e-01 | 0.1276 |
| 50861 | STMN3 | P27T-E | Human | Esophagus | ESCC | 6.94e-05 | 1.57e-01 | 0.1055 |
| 50861 | STMN3 | P28T-E | Human | Esophagus | ESCC | 1.22e-04 | 1.79e-01 | 0.1149 |
| 50861 | STMN3 | P30T-E | Human | Esophagus | ESCC | 2.11e-03 | 3.35e-01 | 0.137 |
| 50861 | STMN3 | P31T-E | Human | Esophagus | ESCC | 1.96e-06 | 1.82e-01 | 0.1251 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| GO:000170119 | Esophagus | ESCC | in utero embryonic development | 243/8552 | 367/18723 | 1.00e-15 | 6.86e-14 | 243 |
| GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
| GO:00705078 | Esophagus | ESCC | regulation of microtubule cytoskeleton organization | 99/8552 | 148/18723 | 1.43e-07 | 2.29e-06 | 99 |
| GO:000726510 | Esophagus | ESCC | Ras protein signal transduction | 201/8552 | 337/18723 | 1.44e-07 | 2.30e-06 | 201 |
| GO:000182412 | Esophagus | ESCC | blastocyst development | 73/8552 | 106/18723 | 1.13e-06 | 1.40e-05 | 73 |
| GO:00166019 | Esophagus | ESCC | Rac protein signal transduction | 33/8552 | 42/18723 | 1.35e-05 | 1.23e-04 | 33 |
| GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
| GO:00311104 | Esophagus | ESCC | regulation of microtubule polymerization or depolymerization | 57/8552 | 88/18723 | 2.32e-04 | 1.44e-03 | 57 |
| GO:00311227 | Esophagus | ESCC | cytoplasmic microtubule organization | 38/8552 | 56/18723 | 6.60e-04 | 3.50e-03 | 38 |
| GO:00328864 | Esophagus | ESCC | regulation of microtubule-based process | 134/8552 | 240/18723 | 9.44e-04 | 4.80e-03 | 134 |
| GO:0035020 | Esophagus | ESCC | regulation of Rac protein signal transduction | 17/8552 | 21/18723 | 1.03e-03 | 5.19e-03 | 17 |
| GO:00465789 | Esophagus | ESCC | regulation of Ras protein signal transduction | 106/8552 | 189/18723 | 2.49e-03 | 1.08e-02 | 106 |
| GO:00436245 | Esophagus | ESCC | cellular protein complex disassembly | 78/8552 | 136/18723 | 4.00e-03 | 1.62e-02 | 78 |
| GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
| GO:005105610 | Esophagus | ESCC | regulation of small GTPase mediated signal transduction | 157/8552 | 302/18723 | 1.55e-02 | 4.98e-02 | 157 |
| GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
| GO:003298411 | Liver | HCC | protein-containing complex disassembly | 138/7958 | 224/18723 | 5.59e-09 | 1.46e-07 | 138 |
| GO:000170111 | Liver | HCC | in utero embryonic development | 204/7958 | 367/18723 | 2.44e-07 | 4.30e-06 | 204 |
| GO:000726521 | Liver | HCC | Ras protein signal transduction | 187/7958 | 337/18723 | 8.89e-07 | 1.35e-05 | 187 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| STMN3 | insertion | Frame_Shift_Ins | novel | c.217_218insGGAGGCAGCCGAGGAGCGGAGGAAGGCAAGGAGTCCTC | p.Ser73TrpfsTer45 | p.S73Wfs*45 | Q9NZ72 | protein_coding | TCGA-AN-A0AS-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
| STMN3 | insertion | Nonsense_Mutation | novel | c.77_78insATGTAAGAAAGTGTTGCCTAGATCCTCCATGGACTC | p.Tyr26delinsTer | p.Y26delins* | Q9NZ72 | protein_coding | TCGA-AO-A0J7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
| STMN3 | SNV | Missense_Mutation | rs556068883 | c.100N>A | p.Val34Ile | p.V34I | Q9NZ72 | protein_coding | tolerated(1) | benign(0) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| STMN3 | SNV | Missense_Mutation | c.484G>C | p.Glu162Gln | p.E162Q | Q9NZ72 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| STMN3 | SNV | Missense_Mutation | c.268G>C | p.Glu90Gln | p.E90Q | Q9NZ72 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| STMN3 | SNV | Missense_Mutation | novel | c.361N>T | p.Ala121Ser | p.A121S | Q9NZ72 | protein_coding | deleterious(0) | possibly_damaging(0.711) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
| STMN3 | SNV | Missense_Mutation | rs772960740 | c.478G>C | p.Glu160Gln | p.E160Q | Q9NZ72 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| STMN3 | SNV | Missense_Mutation | novel | c.194N>T | p.Ser65Phe | p.S65F | Q9NZ72 | protein_coding | deleterious(0.01) | possibly_damaging(0.892) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| STMN3 | SNV | Missense_Mutation | c.149N>T | p.Ser50Leu | p.S50L | Q9NZ72 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AP-A1DO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| STMN3 | SNV | Missense_Mutation | novel | c.27G>T | p.Lys9Asn | p.K9N | Q9NZ72 | protein_coding | deleterious(0) | benign(0.36) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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