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Gene: STK16 |
Gene summary for STK16 |
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Gene information | Species | Human | Gene symbol | STK16 | Gene ID | 8576 |
Gene name | serine/threonine kinase 16 | |
Gene Alias | KRCT | |
Cytomap | 2q35 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R440 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8576 | STK16 | LZE4T | Human | Esophagus | ESCC | 9.65e-05 | 1.57e-01 | 0.0811 |
8576 | STK16 | LZE20T | Human | Esophagus | ESCC | 2.06e-02 | 9.10e-02 | 0.0662 |
8576 | STK16 | LZE24T | Human | Esophagus | ESCC | 7.61e-24 | 6.43e-01 | 0.0596 |
8576 | STK16 | LZE6T | Human | Esophagus | ESCC | 3.94e-07 | 3.12e-01 | 0.0845 |
8576 | STK16 | P1T-E | Human | Esophagus | ESCC | 1.32e-11 | 5.44e-01 | 0.0875 |
8576 | STK16 | P2T-E | Human | Esophagus | ESCC | 3.38e-22 | 4.04e-01 | 0.1177 |
8576 | STK16 | P4T-E | Human | Esophagus | ESCC | 2.53e-10 | 2.73e-01 | 0.1323 |
8576 | STK16 | P5T-E | Human | Esophagus | ESCC | 1.38e-11 | 2.00e-01 | 0.1327 |
8576 | STK16 | P8T-E | Human | Esophagus | ESCC | 8.18e-20 | 3.18e-01 | 0.0889 |
8576 | STK16 | P9T-E | Human | Esophagus | ESCC | 7.01e-09 | 2.00e-01 | 0.1131 |
8576 | STK16 | P10T-E | Human | Esophagus | ESCC | 3.24e-12 | 2.36e-01 | 0.116 |
8576 | STK16 | P11T-E | Human | Esophagus | ESCC | 2.56e-15 | 4.89e-01 | 0.1426 |
8576 | STK16 | P12T-E | Human | Esophagus | ESCC | 1.52e-25 | 4.91e-01 | 0.1122 |
8576 | STK16 | P15T-E | Human | Esophagus | ESCC | 4.55e-26 | 5.36e-01 | 0.1149 |
8576 | STK16 | P16T-E | Human | Esophagus | ESCC | 1.64e-20 | 4.36e-01 | 0.1153 |
8576 | STK16 | P17T-E | Human | Esophagus | ESCC | 1.83e-07 | 2.30e-01 | 0.1278 |
8576 | STK16 | P19T-E | Human | Esophagus | ESCC | 3.40e-02 | 3.50e-01 | 0.1662 |
8576 | STK16 | P20T-E | Human | Esophagus | ESCC | 1.03e-18 | 3.43e-01 | 0.1124 |
8576 | STK16 | P21T-E | Human | Esophagus | ESCC | 9.44e-40 | 7.40e-01 | 0.1617 |
8576 | STK16 | P22T-E | Human | Esophagus | ESCC | 7.22e-29 | 4.65e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00715599 | Esophagus | ESCC | response to transforming growth factor beta | 157/8552 | 256/18723 | 2.95e-07 | 4.23e-06 | 157 |
GO:00715609 | Esophagus | ESCC | cellular response to transforming growth factor beta stimulus | 151/8552 | 250/18723 | 1.78e-06 | 2.10e-05 | 151 |
GO:004677710 | Esophagus | ESCC | protein autophosphorylation | 138/8552 | 227/18723 | 2.98e-06 | 3.38e-05 | 138 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:007155911 | Liver | Cirrhotic | response to transforming growth factor beta | 96/4634 | 256/18723 | 3.55e-06 | 6.09e-05 | 96 |
GO:007156011 | Liver | Cirrhotic | cellular response to transforming growth factor beta stimulus | 93/4634 | 250/18723 | 7.34e-06 | 1.13e-04 | 93 |
GO:007155921 | Liver | HCC | response to transforming growth factor beta | 141/7958 | 256/18723 | 3.08e-05 | 3.16e-04 | 141 |
GO:007156021 | Liver | HCC | cellular response to transforming growth factor beta stimulus | 137/7958 | 250/18723 | 5.47e-05 | 5.14e-04 | 137 |
GO:00467775 | Liver | HCC | protein autophosphorylation | 123/7958 | 227/18723 | 2.40e-04 | 1.80e-03 | 123 |
GO:00715598 | Oral cavity | OSCC | response to transforming growth factor beta | 140/7305 | 256/18723 | 2.34e-07 | 3.70e-06 | 140 |
GO:00715608 | Oral cavity | OSCC | cellular response to transforming growth factor beta stimulus | 137/7305 | 250/18723 | 2.68e-07 | 4.15e-06 | 137 |
GO:00467779 | Oral cavity | OSCC | protein autophosphorylation | 123/7305 | 227/18723 | 2.31e-06 | 2.93e-05 | 123 |
GO:00182123 | Oral cavity | OSCC | peptidyl-tyrosine modification | 180/7305 | 378/18723 | 3.63e-04 | 2.22e-03 | 180 |
GO:00181083 | Oral cavity | OSCC | peptidyl-tyrosine phosphorylation | 177/7305 | 375/18723 | 6.86e-04 | 3.83e-03 | 177 |
GO:007155917 | Skin | cSCC | response to transforming growth factor beta | 95/4864 | 256/18723 | 5.21e-05 | 5.31e-04 | 95 |
GO:007156025 | Skin | cSCC | cellular response to transforming growth factor beta stimulus | 92/4864 | 250/18723 | 9.65e-05 | 8.99e-04 | 92 |
GO:004677715 | Skin | cSCC | protein autophosphorylation | 84/4864 | 227/18723 | 1.53e-04 | 1.35e-03 | 84 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STK16 | SNV | Missense_Mutation | rs371450121 | c.418N>A | p.His140Asn | p.H140N | O75716 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STK16 | SNV | Missense_Mutation | c.313A>G | p.Thr105Ala | p.T105A | O75716 | protein_coding | deleterious(0.01) | possibly_damaging(0.484) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STK16 | insertion | Frame_Shift_Ins | novel | c.267_268insACCTCAAAGATTTCTATATCTCTGCTCCTGAGGAGCTCACG | p.Ala90ThrfsTer35 | p.A90Tfs*35 | O75716 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
STK16 | insertion | Frame_Shift_Ins | novel | c.280_281insCCACTCAC | p.Trp95ThrfsTer19 | p.W95Tfs*19 | O75716 | protein_coding | TCGA-BH-A0BJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
STK16 | SNV | Missense_Mutation | c.701N>T | p.Pro234Leu | p.P234L | O75716 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
STK16 | SNV | Missense_Mutation | novel | c.158G>T | p.Cys53Phe | p.C53F | O75716 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A2RL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | taxol | PD |
STK16 | SNV | Missense_Mutation | novel | c.277G>A | p.Glu93Lys | p.E93K | O75716 | protein_coding | tolerated(0.08) | probably_damaging(0.999) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
STK16 | SNV | Missense_Mutation | c.112N>C | p.Glu38Gln | p.E38Q | O75716 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STK16 | SNV | Missense_Mutation | novel | c.827A>G | p.Asp276Gly | p.D276G | O75716 | protein_coding | deleterious(0.01) | benign(0.318) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
STK16 | SNV | Missense_Mutation | rs548466076 | c.149N>A | p.Arg50Gln | p.R50Q | O75716 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
8576 | STK16 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | inhibitor | 249565890 | ||
8576 | STK16 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
8576 | STK16 | DRUGGABLE GENOME, SERINE THREONINE KINASE, KINASE, ENZYME | inhibitor | 348353651 |
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