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Gene: STING1 |
Gene summary for STING1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | STING1 | Gene ID | 340061 |
| Gene name | stimulator of interferon response cGAMP interactor 1 | |
| Gene Alias | ERIS | |
| Cytomap | 5q31.2 | |
| Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | V5V0K2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 340061 | STING1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.92e-09 | 2.13e-01 | 0.0155 |
| 340061 | STING1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.44e-05 | 1.80e-01 | -0.1808 |
| 340061 | STING1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-03 | 2.52e-01 | 0.0216 |
| 340061 | STING1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.45e-11 | 3.51e-01 | -0.0811 |
| 340061 | STING1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.58e-08 | 2.20e-01 | -0.1088 |
| 340061 | STING1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.55e-12 | 2.57e-01 | -0.1954 |
| 340061 | STING1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.86e-06 | 4.03e-01 | -0.2602 |
| 340061 | STING1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.22e-02 | 1.69e-01 | -0.1207 |
| 340061 | STING1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.40e-01 | -0.1464 |
| 340061 | STING1 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.82e-13 | 2.74e-01 | -0.1001 |
| 340061 | STING1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.72e-12 | 3.38e-01 | -0.059 |
| 340061 | STING1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.52e-06 | 2.80e-01 | -0.2061 |
| 340061 | STING1 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.76e-07 | 2.60e-01 | -0.0842 |
| 340061 | STING1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.60e-01 | -0.0179 |
| 340061 | STING1 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.54e-25 | 4.72e-01 | 0.096 |
| 340061 | STING1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.26e-05 | 3.09e-01 | 0.0131 |
| 340061 | STING1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 9.67e-09 | 4.96e-01 | 0.0171 |
| 340061 | STING1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.13e-08 | 2.58e-01 | 0.0338 |
| 340061 | STING1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.44e-19 | 3.41e-01 | 0.0674 |
| 340061 | STING1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 9.33e-07 | 3.43e-01 | 0.0112 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0009896 | Colorectum | AD | positive regulation of catabolic process | 180/3918 | 492/18723 | 4.33e-16 | 1.94e-13 | 180 |
| GO:0031331 | Colorectum | AD | positive regulation of cellular catabolic process | 156/3918 | 427/18723 | 4.68e-14 | 1.05e-11 | 156 |
| GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
| GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
| GO:0010506 | Colorectum | AD | regulation of autophagy | 111/3918 | 317/18723 | 3.57e-09 | 2.35e-07 | 111 |
| GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
| GO:0051099 | Colorectum | AD | positive regulation of binding | 66/3918 | 173/18723 | 1.47e-07 | 6.64e-06 | 66 |
| GO:1903008 | Colorectum | AD | organelle disassembly | 46/3918 | 114/18723 | 1.81e-06 | 5.48e-05 | 46 |
| GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
| GO:0061912 | Colorectum | AD | selective autophagy | 29/3918 | 68/18723 | 4.20e-05 | 7.39e-04 | 29 |
| GO:0016241 | Colorectum | AD | regulation of macroautophagy | 50/3918 | 141/18723 | 4.55e-05 | 7.92e-04 | 50 |
| GO:0032092 | Colorectum | AD | positive regulation of protein binding | 33/3918 | 85/18723 | 1.22e-04 | 1.78e-03 | 33 |
| GO:0010508 | Colorectum | AD | positive regulation of autophagy | 43/3918 | 124/18723 | 2.64e-04 | 3.27e-03 | 43 |
| GO:0032481 | Colorectum | AD | positive regulation of type I interferon production | 23/3918 | 58/18723 | 8.82e-04 | 8.53e-03 | 23 |
| GO:0051091 | Colorectum | AD | positive regulation of DNA-binding transcription factor activity | 73/3918 | 260/18723 | 3.52e-03 | 2.54e-02 | 73 |
| GO:0007033 | Colorectum | AD | vacuole organization | 53/3918 | 180/18723 | 4.18e-03 | 2.89e-02 | 53 |
| GO:00098961 | Colorectum | SER | positive regulation of catabolic process | 132/2897 | 492/18723 | 4.16e-11 | 6.72e-09 | 132 |
| GO:00313311 | Colorectum | SER | positive regulation of cellular catabolic process | 114/2897 | 427/18723 | 1.22e-09 | 1.27e-07 | 114 |
| GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
| GO:00510981 | Colorectum | SER | regulation of binding | 97/2897 | 363/18723 | 1.98e-08 | 1.43e-06 | 97 |
| Page: 1 2 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa05171 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
| hsa05131 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
| hsa05170 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
| hsa05163 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
| hsa051711 | Colorectum | AD | Coronavirus disease - COVID-19 | 113/2092 | 232/8465 | 9.90e-16 | 2.55e-14 | 1.63e-14 | 113 |
| hsa051311 | Colorectum | AD | Shigellosis | 109/2092 | 247/8465 | 1.09e-11 | 2.44e-10 | 1.55e-10 | 109 |
| hsa051701 | Colorectum | AD | Human immunodeficiency virus 1 infection | 72/2092 | 212/8465 | 1.40e-03 | 8.46e-03 | 5.39e-03 | 72 |
| hsa051631 | Colorectum | AD | Human cytomegalovirus infection | 75/2092 | 225/8465 | 2.00e-03 | 1.10e-02 | 7.01e-03 | 75 |
| hsa051712 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
| hsa051312 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
| hsa051702 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
| hsa051632 | Colorectum | SER | Human cytomegalovirus infection | 57/1580 | 225/8465 | 7.40e-03 | 3.84e-02 | 2.79e-02 | 57 |
| hsa051713 | Colorectum | SER | Coronavirus disease - COVID-19 | 98/1580 | 232/8465 | 3.33e-17 | 8.50e-16 | 6.17e-16 | 98 |
| hsa051313 | Colorectum | SER | Shigellosis | 87/1580 | 247/8465 | 3.07e-10 | 7.27e-09 | 5.28e-09 | 87 |
| hsa051703 | Colorectum | SER | Human immunodeficiency virus 1 infection | 58/1580 | 212/8465 | 1.08e-03 | 8.56e-03 | 6.21e-03 | 58 |
| hsa051633 | Colorectum | SER | Human cytomegalovirus infection | 57/1580 | 225/8465 | 7.40e-03 | 3.84e-02 | 2.79e-02 | 57 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 340061 | STING1 | CLINICALLY ACTIONABLE, KINASE | agonist | 381118902 | ADU-S100 | |
| 340061 | STING1 | CLINICALLY ACTIONABLE, KINASE | agonist | 315661283 | ||
| 340061 | STING1 | CLINICALLY ACTIONABLE, KINASE | antagonist | 381118832 | ||
| 340061 | STING1 | CLINICALLY ACTIONABLE, KINASE | agonist | 381118837 | ||
| 340061 | STING1 | CLINICALLY ACTIONABLE, KINASE | agonist | 381118838 | ||
| 340061 | STING1 | CLINICALLY ACTIONABLE, KINASE | ADU-S100 | ADU-S100 | ||
| 340061 | STING1 | CLINICALLY ACTIONABLE, KINASE | MK-1454 |
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