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Gene: STEAP1 |
Gene summary for STEAP1 |
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Gene information | Species | Human | Gene symbol | STEAP1 | Gene ID | 26872 |
Gene name | STEAP family member 1 | |
Gene Alias | PRSS24 | |
Cytomap | 7q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9UHE8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26872 | STEAP1 | LZE5T | Human | Esophagus | ESCC | 1.66e-02 | 7.09e-01 | 0.0514 |
26872 | STEAP1 | LZE8T | Human | Esophagus | ESCC | 9.72e-05 | 2.89e-01 | 0.067 |
26872 | STEAP1 | LZE20T | Human | Esophagus | ESCC | 8.04e-06 | 1.71e-01 | 0.0662 |
26872 | STEAP1 | LZE22T | Human | Esophagus | ESCC | 2.15e-05 | 6.47e-01 | 0.068 |
26872 | STEAP1 | LZE24T | Human | Esophagus | ESCC | 1.97e-13 | 5.24e-01 | 0.0596 |
26872 | STEAP1 | LZE21T | Human | Esophagus | ESCC | 3.54e-06 | 5.18e-01 | 0.0655 |
26872 | STEAP1 | P1T-E | Human | Esophagus | ESCC | 3.05e-03 | 5.22e-01 | 0.0875 |
26872 | STEAP1 | P2T-E | Human | Esophagus | ESCC | 1.56e-23 | 5.82e-01 | 0.1177 |
26872 | STEAP1 | P4T-E | Human | Esophagus | ESCC | 6.72e-41 | 1.23e+00 | 0.1323 |
26872 | STEAP1 | P5T-E | Human | Esophagus | ESCC | 6.23e-18 | 6.03e-01 | 0.1327 |
26872 | STEAP1 | P8T-E | Human | Esophagus | ESCC | 1.57e-27 | 6.59e-01 | 0.0889 |
26872 | STEAP1 | P9T-E | Human | Esophagus | ESCC | 1.92e-39 | 1.25e+00 | 0.1131 |
26872 | STEAP1 | P10T-E | Human | Esophagus | ESCC | 1.02e-33 | 6.85e-01 | 0.116 |
26872 | STEAP1 | P11T-E | Human | Esophagus | ESCC | 1.79e-02 | 3.28e-01 | 0.1426 |
26872 | STEAP1 | P12T-E | Human | Esophagus | ESCC | 2.37e-38 | 1.04e+00 | 0.1122 |
26872 | STEAP1 | P15T-E | Human | Esophagus | ESCC | 3.44e-56 | 1.38e+00 | 0.1149 |
26872 | STEAP1 | P16T-E | Human | Esophagus | ESCC | 7.67e-47 | 1.07e+00 | 0.1153 |
26872 | STEAP1 | P20T-E | Human | Esophagus | ESCC | 2.30e-33 | 1.01e+00 | 0.1124 |
26872 | STEAP1 | P21T-E | Human | Esophagus | ESCC | 4.95e-18 | 4.59e-01 | 0.1617 |
26872 | STEAP1 | P22T-E | Human | Esophagus | ESCC | 3.47e-10 | 4.10e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005507617 | Esophagus | ESCC | transition metal ion homeostasis | 87/8552 | 138/18723 | 2.85e-05 | 2.37e-04 | 87 |
GO:00550729 | Esophagus | ESCC | iron ion homeostasis | 52/8552 | 85/18723 | 2.86e-03 | 1.21e-02 | 52 |
GO:00550766 | Liver | Cirrhotic | transition metal ion homeostasis | 59/4634 | 138/18723 | 2.59e-06 | 4.65e-05 | 59 |
GO:00550724 | Liver | Cirrhotic | iron ion homeostasis | 35/4634 | 85/18723 | 6.22e-04 | 4.79e-03 | 35 |
GO:005507612 | Liver | HCC | transition metal ion homeostasis | 81/7958 | 138/18723 | 8.87e-05 | 7.72e-04 | 81 |
GO:005507211 | Liver | HCC | iron ion homeostasis | 47/7958 | 85/18723 | 1.17e-02 | 4.28e-02 | 47 |
GO:005507610 | Oral cavity | OSCC | transition metal ion homeostasis | 81/7305 | 138/18723 | 2.13e-06 | 2.72e-05 | 81 |
GO:00550728 | Oral cavity | OSCC | iron ion homeostasis | 46/7305 | 85/18723 | 3.31e-03 | 1.42e-02 | 46 |
GO:00550769 | Prostate | BPH | transition metal ion homeostasis | 43/3107 | 138/18723 | 1.66e-05 | 2.07e-04 | 43 |
GO:00550727 | Prostate | BPH | iron ion homeostasis | 29/3107 | 85/18723 | 6.22e-05 | 6.23e-04 | 29 |
GO:005507615 | Prostate | Tumor | transition metal ion homeostasis | 45/3246 | 138/18723 | 9.11e-06 | 1.33e-04 | 45 |
GO:005507213 | Prostate | Tumor | iron ion homeostasis | 31/3246 | 85/18723 | 1.89e-05 | 2.47e-04 | 31 |
GO:005507632 | Thyroid | ATC | transition metal ion homeostasis | 66/6293 | 138/18723 | 3.64e-04 | 2.25e-03 | 66 |
GO:005507214 | Thyroid | ATC | iron ion homeostasis | 41/6293 | 85/18723 | 3.62e-03 | 1.58e-02 | 41 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0497814 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
hsa0497815 | Prostate | BPH | Mineral absorption | 20/1718 | 60/8465 | 1.22e-02 | 3.61e-02 | 2.23e-02 | 20 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STEAP1 | SNV | Missense_Mutation | novel | c.918N>A | p.Ser306Arg | p.S306R | Q9UHE8 | protein_coding | tolerated(0.35) | benign(0) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STEAP1 | SNV | Missense_Mutation | c.957N>C | p.Lys319Asn | p.K319N | Q9UHE8 | protein_coding | deleterious(0) | benign(0.327) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
STEAP1 | SNV | Missense_Mutation | rs753718544 | c.542N>G | p.Ser181Cys | p.S181C | Q9UHE8 | protein_coding | tolerated(1) | benign(0.022) | TCGA-AC-A2B8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | chemo | PD |
STEAP1 | insertion | In_Frame_Ins | novel | c.919_920insTGCCTTTTATGT | p.Ile307delinsMetProPheMetLeu | p.I307delinsMPFML | Q9UHE8 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
STEAP1 | SNV | Missense_Mutation | c.628N>A | p.Glu210Lys | p.E210K | Q9UHE8 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STEAP1 | SNV | Missense_Mutation | c.848N>G | p.Phe283Cys | p.F283C | Q9UHE8 | protein_coding | deleterious(0) | possibly_damaging(0.733) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
STEAP1 | SNV | Missense_Mutation | novel | c.531T>G | p.Ile177Met | p.I177M | Q9UHE8 | protein_coding | deleterious(0.01) | benign(0.255) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
STEAP1 | SNV | Missense_Mutation | c.921A>G | p.Ile307Met | p.I307M | Q9UHE8 | protein_coding | deleterious(0) | benign(0.347) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STEAP1 | SNV | Missense_Mutation | c.43A>G | p.Lys15Glu | p.K15E | Q9UHE8 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-QG-A5YW-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | CR | |
STEAP1 | SNV | Missense_Mutation | novel | c.860C>T | p.Thr287Ile | p.T287I | Q9UHE8 | protein_coding | tolerated(0.05) | benign(0.36) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26872 | STEAP1 | TRANSPORTER, DRUGGABLE GENOME | RG7450 | VANDORTUZUMAB VEDOTIN | 24424355 |
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