Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: STBD1

Gene summary for STBD1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

STBD1

Gene ID

8987

Gene namestarch binding domain 1
Gene AliasGENEX3414
Cytomap4q21.1
Gene Typeprotein-coding
GO ID

GO:0000272

UniProtAcc

O95210


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8987STBD1HTA11_2487_2000001011HumanColorectumSER3.82e-205.34e-01-0.1808
8987STBD1HTA11_1938_2000001011HumanColorectumAD9.49e-041.86e-01-0.0811
8987STBD1HTA11_78_2000001011HumanColorectumAD8.17e-122.98e-01-0.1088
8987STBD1HTA11_347_2000001011HumanColorectumAD5.11e-255.12e-01-0.1954
8987STBD1HTA11_411_2000001011HumanColorectumSER5.61e-033.68e-01-0.2602
8987STBD1HTA11_2112_2000001011HumanColorectumSER1.08e-066.83e-01-0.2196
8987STBD1HTA11_3361_2000001011HumanColorectumAD1.71e-104.09e-01-0.1207
8987STBD1HTA11_83_2000001011HumanColorectumSER1.46e-113.34e-01-0.1526
8987STBD1HTA11_696_2000001011HumanColorectumAD4.08e-112.21e-01-0.1464
8987STBD1HTA11_866_2000001011HumanColorectumAD2.05e-061.72e-01-0.1001
8987STBD1HTA11_1391_2000001011HumanColorectumAD1.37e-031.30e-01-0.059
8987STBD1HTA11_5212_2000001011HumanColorectumAD8.16e-073.63e-01-0.2061
8987STBD1HTA11_5216_2000001011HumanColorectumSER2.79e-075.15e-01-0.1462
8987STBD1HTA11_7862_2000001011HumanColorectumAD1.24e-021.60e-01-0.0179
8987STBD1HTA11_866_3004761011HumanColorectumAD1.58e-031.30e-010.096
8987STBD1HTA11_10623_2000001011HumanColorectumAD3.04e-052.44e-01-0.0177
8987STBD1HTA11_99999971662_82457HumanColorectumMSS1.82e-031.18e-010.3859
8987STBD1S014HumanLiverHCC2.09e-061.96e-010.2254
8987STBD1S015HumanLiverHCC9.93e-113.10e-010.2375
8987STBD1S016HumanLiverHCC1.41e-082.29e-010.2243
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006091ColorectumADgeneration of precursor metabolites and energy209/3918490/187233.17e-286.61e-25209
GO:0015980ColorectumADenergy derivation by oxidation of organic compounds143/3918318/187232.78e-222.49e-19143
GO:0016236ColorectumADmacroautophagy103/3918291/187236.76e-094.15e-07103
GO:0016052ColorectumADcarbohydrate catabolic process56/3918154/187237.01e-061.73e-0456
GO:0061912ColorectumADselective autophagy29/391868/187234.20e-057.39e-0429
GO:0044262ColorectumADcellular carbohydrate metabolic process87/3918283/187236.00e-051.01e-0387
GO:00060911ColorectumSERgeneration of precursor metabolites and energy168/2897490/187231.39e-251.70e-22168
GO:00159801ColorectumSERenergy derivation by oxidation of organic compounds119/2897318/187235.28e-224.62e-19119
GO:00162361ColorectumSERmacroautophagy79/2897291/187231.97e-071.10e-0579
GO:00619121ColorectumSERselective autophagy24/289768/187234.60e-051.15e-0324
GO:00160521ColorectumSERcarbohydrate catabolic process38/2897154/187231.92e-031.93e-0238
GO:00060912ColorectumMSSgeneration of precursor metabolites and energy186/3467490/187231.14e-242.15e-21186
GO:00159802ColorectumMSSenergy derivation by oxidation of organic compounds131/3467318/187232.60e-212.70e-18131
GO:00162362ColorectumMSSmacroautophagy93/3467291/187232.08e-081.17e-0693
GO:00619122ColorectumMSSselective autophagy27/346768/187233.68e-057.09e-0427
GO:00160522ColorectumMSScarbohydrate catabolic process45/3467154/187237.93e-048.36e-0345
GO:000609122LiverHCCgeneration of precursor metabolites and energy340/7958490/187234.04e-342.85e-31340
GO:001598022LiverHCCenergy derivation by oxidation of organic compounds221/7958318/187231.02e-221.86e-20221
GO:001623621LiverHCCmacroautophagy204/7958291/187238.66e-221.41e-19204
GO:001605222LiverHCCcarbohydrate catabolic process99/7958154/187233.79e-088.30e-0799
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
STBD1SNVMissense_Mutationc.540N>Cp.Lys180Asnp.K180NO95210protein_codingtolerated(0.46)benign(0.007)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
STBD1deletionFrame_Shift_Delnovelc.531delNp.Leu178CysfsTer10p.L178Cfs*10O95210protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
STBD1SNVMissense_Mutationc.910N>Ap.Asp304Asnp.D304NO95210protein_codingdeleterious(0.01)probably_damaging(0.911)TCGA-AA-3678-01Colorectumcolon adenocarcinomaFemale<65III/IVChemotherapyfolinicCR
STBD1SNVMissense_Mutationc.844G>Ap.Ala282Thrp.A282TO95210protein_codingdeleterious(0)probably_damaging(0.997)TCGA-F4-6856-01Colorectumcolon adenocarcinomaMale<65I/IIAncillaryleucovorinCR
STBD1SNVMissense_Mutationnovelc.67C>Ap.Leu23Metp.L23MO95210protein_codingdeleterious(0.03)benign(0.386)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
STBD1SNVMissense_Mutationnovelc.443C>Ap.Ser148Tyrp.S148YO95210protein_codingtolerated(0.12)possibly_damaging(0.781)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
STBD1SNVMissense_Mutationnovelc.181N>Gp.Ser61Glyp.S61GO95210protein_codingtolerated(0.2)benign(0.08)TCGA-B5-A3FA-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
STBD1SNVMissense_Mutationrs140083759c.998G>Ap.Arg333Hisp.R333HO95210protein_codingdeleterious(0)probably_damaging(1)TCGA-B5-A3FC-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
STBD1SNVMissense_Mutationc.713C>Ap.Thr238Asnp.T238NO95210protein_codingtolerated(0.3)benign(0.125)TCGA-BG-A0M0-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
STBD1SNVMissense_Mutationc.413N>Tp.Ser138Phep.S138FO95210protein_codingtolerated(0.06)possibly_damaging(0.78)TCGA-BK-A0C9-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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