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Gene: STBD1 |
Gene summary for STBD1 |
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Gene information | Species | Human | Gene symbol | STBD1 | Gene ID | 8987 |
Gene name | starch binding domain 1 | |
Gene Alias | GENEX3414 | |
Cytomap | 4q21.1 | |
Gene Type | protein-coding | GO ID | GO:0000272 | UniProtAcc | O95210 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8987 | STBD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.82e-20 | 5.34e-01 | -0.1808 |
8987 | STBD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.49e-04 | 1.86e-01 | -0.0811 |
8987 | STBD1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.17e-12 | 2.98e-01 | -0.1088 |
8987 | STBD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.11e-25 | 5.12e-01 | -0.1954 |
8987 | STBD1 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 3.68e-01 | -0.2602 |
8987 | STBD1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.08e-06 | 6.83e-01 | -0.2196 |
8987 | STBD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.71e-10 | 4.09e-01 | -0.1207 |
8987 | STBD1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.46e-11 | 3.34e-01 | -0.1526 |
8987 | STBD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.08e-11 | 2.21e-01 | -0.1464 |
8987 | STBD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.05e-06 | 1.72e-01 | -0.1001 |
8987 | STBD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.37e-03 | 1.30e-01 | -0.059 |
8987 | STBD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.16e-07 | 3.63e-01 | -0.2061 |
8987 | STBD1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.79e-07 | 5.15e-01 | -0.1462 |
8987 | STBD1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.60e-01 | -0.0179 |
8987 | STBD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.58e-03 | 1.30e-01 | 0.096 |
8987 | STBD1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 3.04e-05 | 2.44e-01 | -0.0177 |
8987 | STBD1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.82e-03 | 1.18e-01 | 0.3859 |
8987 | STBD1 | S014 | Human | Liver | HCC | 2.09e-06 | 1.96e-01 | 0.2254 |
8987 | STBD1 | S015 | Human | Liver | HCC | 9.93e-11 | 3.10e-01 | 0.2375 |
8987 | STBD1 | S016 | Human | Liver | HCC | 1.41e-08 | 2.29e-01 | 0.2243 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0015980 | Colorectum | AD | energy derivation by oxidation of organic compounds | 143/3918 | 318/18723 | 2.78e-22 | 2.49e-19 | 143 |
GO:0016236 | Colorectum | AD | macroautophagy | 103/3918 | 291/18723 | 6.76e-09 | 4.15e-07 | 103 |
GO:0016052 | Colorectum | AD | carbohydrate catabolic process | 56/3918 | 154/18723 | 7.01e-06 | 1.73e-04 | 56 |
GO:0061912 | Colorectum | AD | selective autophagy | 29/3918 | 68/18723 | 4.20e-05 | 7.39e-04 | 29 |
GO:0044262 | Colorectum | AD | cellular carbohydrate metabolic process | 87/3918 | 283/18723 | 6.00e-05 | 1.01e-03 | 87 |
GO:00060911 | Colorectum | SER | generation of precursor metabolites and energy | 168/2897 | 490/18723 | 1.39e-25 | 1.70e-22 | 168 |
GO:00159801 | Colorectum | SER | energy derivation by oxidation of organic compounds | 119/2897 | 318/18723 | 5.28e-22 | 4.62e-19 | 119 |
GO:00162361 | Colorectum | SER | macroautophagy | 79/2897 | 291/18723 | 1.97e-07 | 1.10e-05 | 79 |
GO:00619121 | Colorectum | SER | selective autophagy | 24/2897 | 68/18723 | 4.60e-05 | 1.15e-03 | 24 |
GO:00160521 | Colorectum | SER | carbohydrate catabolic process | 38/2897 | 154/18723 | 1.92e-03 | 1.93e-02 | 38 |
GO:00060912 | Colorectum | MSS | generation of precursor metabolites and energy | 186/3467 | 490/18723 | 1.14e-24 | 2.15e-21 | 186 |
GO:00159802 | Colorectum | MSS | energy derivation by oxidation of organic compounds | 131/3467 | 318/18723 | 2.60e-21 | 2.70e-18 | 131 |
GO:00162362 | Colorectum | MSS | macroautophagy | 93/3467 | 291/18723 | 2.08e-08 | 1.17e-06 | 93 |
GO:00619122 | Colorectum | MSS | selective autophagy | 27/3467 | 68/18723 | 3.68e-05 | 7.09e-04 | 27 |
GO:00160522 | Colorectum | MSS | carbohydrate catabolic process | 45/3467 | 154/18723 | 7.93e-04 | 8.36e-03 | 45 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:001598022 | Liver | HCC | energy derivation by oxidation of organic compounds | 221/7958 | 318/18723 | 1.02e-22 | 1.86e-20 | 221 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:001605222 | Liver | HCC | carbohydrate catabolic process | 99/7958 | 154/18723 | 3.79e-08 | 8.30e-07 | 99 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STBD1 | SNV | Missense_Mutation | c.540N>C | p.Lys180Asn | p.K180N | O95210 | protein_coding | tolerated(0.46) | benign(0.007) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
STBD1 | deletion | Frame_Shift_Del | novel | c.531delN | p.Leu178CysfsTer10 | p.L178Cfs*10 | O95210 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
STBD1 | SNV | Missense_Mutation | c.910N>A | p.Asp304Asn | p.D304N | O95210 | protein_coding | deleterious(0.01) | probably_damaging(0.911) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR | |
STBD1 | SNV | Missense_Mutation | c.844G>A | p.Ala282Thr | p.A282T | O95210 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
STBD1 | SNV | Missense_Mutation | novel | c.67C>A | p.Leu23Met | p.L23M | O95210 | protein_coding | deleterious(0.03) | benign(0.386) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
STBD1 | SNV | Missense_Mutation | novel | c.443C>A | p.Ser148Tyr | p.S148Y | O95210 | protein_coding | tolerated(0.12) | possibly_damaging(0.781) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
STBD1 | SNV | Missense_Mutation | novel | c.181N>G | p.Ser61Gly | p.S61G | O95210 | protein_coding | tolerated(0.2) | benign(0.08) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STBD1 | SNV | Missense_Mutation | rs140083759 | c.998G>A | p.Arg333His | p.R333H | O95210 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STBD1 | SNV | Missense_Mutation | c.713C>A | p.Thr238Asn | p.T238N | O95210 | protein_coding | tolerated(0.3) | benign(0.125) | TCGA-BG-A0M0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STBD1 | SNV | Missense_Mutation | c.413N>T | p.Ser138Phe | p.S138F | O95210 | protein_coding | tolerated(0.06) | possibly_damaging(0.78) | TCGA-BK-A0C9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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