Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/STAT6_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/STAT6_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/STAT6_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/STAT6_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/STAT6_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/STAT6_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/STAT6_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/STAT6_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0051052 | Colorectum | AD | regulation of DNA metabolic process | 116/3918 | 359/18723 | 2.47e-07 | 1.00e-05 | 116 |
GO:0051054 | Colorectum | AD | positive regulation of DNA metabolic process | 73/3918 | 201/18723 | 3.27e-07 | 1.29e-05 | 73 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0000302 | Colorectum | AD | response to reactive oxygen species | 78/3918 | 222/18723 | 6.17e-07 | 2.21e-05 | 78 |
GO:1901653 | Colorectum | AD | cellular response to peptide | 114/3918 | 359/18723 | 8.32e-07 | 2.88e-05 | 114 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0071375 | Colorectum | AD | cellular response to peptide hormone stimulus | 95/3918 | 290/18723 | 1.50e-06 | 4.66e-05 | 95 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:0043434 | Colorectum | AD | response to peptide hormone | 126/3918 | 414/18723 | 2.70e-06 | 7.86e-05 | 126 |
GO:0042542 | Colorectum | AD | response to hydrogen peroxide | 52/3918 | 146/18723 | 2.83e-05 | 5.30e-04 | 52 |
GO:0061180 | Colorectum | AD | mammary gland epithelium development | 28/3918 | 67/18723 | 8.74e-05 | 1.35e-03 | 28 |
GO:0022612 | Colorectum | AD | gland morphogenesis | 42/3918 | 118/18723 | 1.62e-04 | 2.23e-03 | 42 |
GO:0034614 | Colorectum | AD | cellular response to reactive oxygen species | 50/3918 | 155/18723 | 6.25e-04 | 6.49e-03 | 50 |
GO:0050673 | Colorectum | AD | epithelial cell proliferation | 119/3918 | 437/18723 | 8.75e-04 | 8.51e-03 | 119 |
GO:0060443 | Colorectum | AD | mammary gland morphogenesis | 18/3918 | 43/18723 | 1.51e-03 | 1.27e-02 | 18 |
GO:0033598 | Colorectum | AD | mammary gland epithelial cell proliferation | 12/3918 | 26/18723 | 3.47e-03 | 2.51e-02 | 12 |
GO:0120162 | Colorectum | AD | positive regulation of cold-induced thermogenesis | 32/3918 | 97/18723 | 3.74e-03 | 2.63e-02 | 32 |
GO:0106106 | Colorectum | AD | cold-induced thermogenesis | 43/3918 | 144/18723 | 7.05e-03 | 4.31e-02 | 43 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STAT6 | SNV | Missense_Mutation | novel | c.2233N>G | p.Leu745Val | p.L745V | P42226 | protein_coding | tolerated_low_confidence(0.13) | benign(0.055) | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
STAT6 | SNV | Missense_Mutation | novel | c.85N>T | p.Leu29Phe | p.L29F | P42226 | protein_coding | tolerated(0.35) | benign(0.085) | TCGA-A2-A0CK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR |
STAT6 | SNV | Missense_Mutation | novel | c.257N>A | p.Ser86Asn | p.S86N | P42226 | protein_coding | tolerated(0.98) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAT6 | SNV | Missense_Mutation | rs778871413 | c.173N>T | p.Ser58Leu | p.S58L | P42226 | protein_coding | deleterious(0.04) | possibly_damaging(0.498) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STAT6 | SNV | Missense_Mutation | | c.737N>A | p.Gly246Asp | p.G246D | P42226 | protein_coding | tolerated(0.15) | benign(0.142) | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
STAT6 | SNV | Missense_Mutation | novel | c.1693N>A | p.Asp565Asn | p.D565N | P42226 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
STAT6 | SNV | Missense_Mutation | | c.1864G>T | p.Asp622Tyr | p.D622Y | P42226 | protein_coding | deleterious(0) | possibly_damaging(0.67) | TCGA-EW-A1P4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
STAT6 | deletion | Frame_Shift_Del | novel | c.398delN | p.Gly133AlafsTer9 | p.G133Afs*9 | P42226 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
STAT6 | SNV | Missense_Mutation | novel | c.1669N>A | p.Gly557Arg | p.G557R | P42226 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STAT6 | SNV | Missense_Mutation | novel | c.2059N>T | p.Asp687Tyr | p.D687Y | P42226 | protein_coding | deleterious(0.03) | possibly_damaging(0.62) | TCGA-C5-A7XC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | NSC-607097 | CHEMBL1374370 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | GW7074 | CHEMBL72365 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | DOXORUBICIN HYDROCHLORIDE | DOXORUBICIN HYDROCHLORIDE | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | EOTAXIN | | 12576300 |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | GLUCOCORTICOID | | 15544592 |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | ELLIPTECINE | ELLIPTECINE | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | NSC-176327 | CHEMBL363332 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | NSC-119889 | CHEMBL516616 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | SU-6656 | CHEMBL605003 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | SANGUINARIUM | SANGUINARIUM | |