|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: STAG3L5P-PVRIG2P-PILRB |
Gene summary for STAG3L5P-PVRIG2P-PILRB |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | STAG3L5P-PVRIG2P-PILRB | Gene ID | 101752399 |
| Gene name | STAG3L5P-PVRIG2P-PILRB readthrough | |
| Gene Alias | FDFACT | |
| Cytomap | 7q22.1 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | CCI_1 | Human | Cervix | CC | 7.83e-16 | 5.99e-01 | 0.528 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | CCI_2 | Human | Cervix | CC | 1.42e-17 | 8.48e-01 | 0.5249 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | CCI_3 | Human | Cervix | CC | 3.66e-13 | 4.11e-01 | 0.516 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.29e-05 | 1.54e-01 | 0.0155 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.37e-03 | 1.44e-01 | -0.1808 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.93e-01 | 0.0216 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.51e-07 | 2.32e-01 | -0.0811 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_78_2000001011 | Human | Colorectum | AD | 5.51e-17 | 4.55e-01 | -0.1088 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_347_2000001011 | Human | Colorectum | AD | 1.52e-31 | 5.47e-01 | -0.1954 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_411_2000001011 | Human | Colorectum | SER | 2.78e-05 | 3.31e-01 | -0.2602 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.90e-02 | 2.44e-01 | -0.2196 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_83_2000001011 | Human | Colorectum | SER | 4.95e-16 | 5.32e-01 | -0.1526 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_696_2000001011 | Human | Colorectum | AD | 4.08e-11 | 2.73e-01 | -0.1464 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_866_2000001011 | Human | Colorectum | AD | 2.67e-20 | 3.55e-01 | -0.1001 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.65e-19 | 4.10e-01 | -0.059 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.79e-07 | 3.89e-01 | -0.1462 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-08 | 2.75e-01 | -0.0842 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.47e-08 | 3.22e-01 | -0.0179 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_866_3004761011 | Human | Colorectum | AD | 4.76e-13 | 3.14e-01 | 0.096 |
| 101752399 | STAG3L5P-PVRIG2P-PILRB | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.95e-07 | 2.87e-01 | 0.0528 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |