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Gene: STAG3 |
Gene summary for STAG3 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | STAG3 | Gene ID | 10734 |
| Gene name | stromal antigen 3 | |
| Gene Alias | STAG3 | |
| Cytomap | 7q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9UJ98 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10734 | STAG3 | C43 | Human | Oral cavity | OSCC | 4.20e-20 | 4.40e-01 | 0.1704 |
| 10734 | STAG3 | C46 | Human | Oral cavity | OSCC | 1.32e-26 | 5.33e-01 | 0.1673 |
| 10734 | STAG3 | C57 | Human | Oral cavity | OSCC | 2.24e-10 | 3.55e-01 | 0.1679 |
| 10734 | STAG3 | LN46 | Human | Oral cavity | OSCC | 1.96e-18 | 6.08e-01 | 0.1666 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00008191 | Liver | HCC | sister chromatid segregation | 128/7958 | 202/18723 | 1.59e-09 | 4.73e-08 | 128 |
| GO:0007059 | Liver | HCC | chromosome segregation | 197/7958 | 346/18723 | 3.57e-08 | 7.87e-07 | 197 |
| GO:0098813 | Liver | HCC | nuclear chromosome segregation | 157/7958 | 281/18723 | 3.82e-06 | 4.95e-05 | 157 |
| GO:00070624 | Liver | HCC | sister chromatid cohesion | 38/7958 | 62/18723 | 2.18e-03 | 1.09e-02 | 38 |
| GO:00008193 | Oral cavity | OSCC | sister chromatid segregation | 135/7305 | 202/18723 | 8.88e-16 | 6.52e-14 | 135 |
| GO:00070592 | Oral cavity | OSCC | chromosome segregation | 206/7305 | 346/18723 | 5.82e-15 | 3.76e-13 | 206 |
| GO:00482852 | Oral cavity | OSCC | organelle fission | 265/7305 | 488/18723 | 3.22e-12 | 1.27e-10 | 265 |
| GO:00002801 | Oral cavity | OSCC | nuclear division | 237/7305 | 439/18723 | 9.62e-11 | 2.90e-09 | 237 |
| GO:00988132 | Oral cavity | OSCC | nuclear chromosome segregation | 162/7305 | 281/18723 | 1.56e-10 | 4.56e-09 | 162 |
| GO:00070626 | Oral cavity | OSCC | sister chromatid cohesion | 37/7305 | 62/18723 | 7.79e-04 | 4.23e-03 | 37 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| STAG3 | SNV | Missense_Mutation | rs539912996 | c.1402C>T | p.Arg468Cys | p.R468C | protein_coding | deleterious(0) | benign(0.014) | TCGA-AC-A6IX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| STAG3 | SNV | Missense_Mutation | novel | c.239A>G | p.Lys80Arg | p.K80R | protein_coding | tolerated(0.23) | probably_damaging(0.968) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| STAG3 | SNV | Missense_Mutation | rs746707797 | c.1780N>A | p.Asp594Asn | p.D594N | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| STAG3 | SNV | Missense_Mutation | c.3047N>T | p.Ser1016Phe | p.S1016F | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
| STAG3 | SNV | Missense_Mutation | novel | c.2854N>A | p.Pro952Thr | p.P952T | protein_coding | tolerated(0.12) | probably_damaging(0.922) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
| STAG3 | SNV | Missense_Mutation | c.331N>T | p.Met111Leu | p.M111L | protein_coding | tolerated(0.29) | benign(0.006) | TCGA-D8-A1XR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD | ||
| STAG3 | SNV | Missense_Mutation | rs539912996 | c.1402N>T | p.Arg468Cys | p.R468C | protein_coding | deleterious(0) | benign(0.014) | TCGA-LL-A5YN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
| STAG3 | insertion | Frame_Shift_Ins | novel | c.633_634insTTGTGCTTCTTGGCAAAGCA | p.Pro212LeufsTer36 | p.P212Lfs*36 | protein_coding | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
| STAG3 | insertion | Nonsense_Mutation | novel | c.2451_2452insCTTCCCAGGTGAGTGTGGGTCTTAGATGGGATAAT | p.Gly818LeufsTer4 | p.G818Lfs*4 | protein_coding | TCGA-A8-A094-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
| STAG3 | insertion | Nonsense_Mutation | novel | c.2030_2031insGCTCGGCTGAAGGACTGGGAGGGTCTGACAAGC | p.Arg677_Phe678insLeuGlyTerArgThrGlyArgValTerGlnAla | p.R677_F678insLG*RTGRV*QA | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 10734 | STAG3 | DRUG RESISTANCE | VEMURAFENIB | VEMURAFENIB | 27500726 |
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