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Gene: ST8SIA4 |
Gene summary for ST8SIA4 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | ST8SIA4 | Gene ID | 7903 |
| Gene name | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 | |
| Gene Alias | PST | |
| Cytomap | 5q21.1 | |
| Gene Type | protein-coding | GO ID | GO:0001573 | UniProtAcc | Q92187 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7903 | ST8SIA4 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 1.30e-05 | 6.56e-01 | -0.0961 |
| 7903 | ST8SIA4 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 6.50e-05 | 5.81e-01 | -0.0876 |
| 7903 | ST8SIA4 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 3.38e-04 | 6.19e-01 | -0.0822 |
| 7903 | ST8SIA4 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 2.17e-03 | 5.07e-01 | -0.0809 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00064863 | Lung | AIS | protein glycosylation | 35/1849 | 226/18723 | 4.93e-03 | 4.27e-02 | 35 |
| GO:00434133 | Lung | AIS | macromolecule glycosylation | 35/1849 | 226/18723 | 4.93e-03 | 4.27e-02 | 35 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| ST8SIA4 | SNV | Missense_Mutation | c.469G>C | p.Gly157Arg | p.G157R | Q92187 | protein_coding | probably_damaging(1) | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
| ST8SIA4 | SNV | Missense_Mutation | c.830N>C | p.Arg277Thr | p.R277T | Q92187 | protein_coding | benign(0.099) | TCGA-D8-A27M-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate+5 | SD | ||
| ST8SIA4 | SNV | Missense_Mutation | novel | c.509A>G | p.Asn170Ser | p.N170S | Q92187 | protein_coding | probably_damaging(0.941) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ST8SIA4 | SNV | Missense_Mutation | novel | c.284T>G | p.Val95Gly | p.V95G | Q92187 | protein_coding | benign(0.341) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| ST8SIA4 | SNV | Missense_Mutation | c.5N>A | p.Arg2His | p.R2H | Q92187 | protein_coding | probably_damaging(0.964) | TCGA-AA-3496-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| ST8SIA4 | SNV | Missense_Mutation | c.863N>T | p.Ala288Val | p.A288V | Q92187 | protein_coding | probably_damaging(0.941) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
| ST8SIA4 | SNV | Missense_Mutation | c.464N>C | p.Glu155Ala | p.E155A | Q92187 | protein_coding | benign(0.001) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
| ST8SIA4 | SNV | Missense_Mutation | c.470N>C | p.Gly157Ala | p.G157A | Q92187 | protein_coding | probably_damaging(1) | TCGA-AA-3693-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
| ST8SIA4 | SNV | Missense_Mutation | c.4N>T | p.Arg2Cys | p.R2C | Q92187 | protein_coding | probably_damaging(0.973) | TCGA-AA-3872-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
| ST8SIA4 | SNV | Missense_Mutation | c.873N>A | p.Phe291Leu | p.F291L | Q92187 | protein_coding | possibly_damaging(0.794) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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