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Gene: SSUH2 |
Gene summary for SSUH2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SSUH2 | Gene ID | 51066 |
| Gene name | ssu-2 homolog | |
| Gene Alias | C3orf32 | |
| Cytomap | 3p25.3 | |
| Gene Type | protein-coding | GO ID | GO:0007275 | UniProtAcc | Q9Y2M2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 51066 | SSUH2 | HCC1_Meng | Human | Liver | HCC | 3.48e-08 | 2.15e-02 | 0.0246 |
| 51066 | SSUH2 | Pt14.a | Human | Liver | HCC | 6.10e-03 | 1.76e-01 | 0.0169 |
| 51066 | SSUH2 | S016 | Human | Liver | HCC | 3.39e-02 | 1.24e-01 | 0.2243 |
| 51066 | SSUH2 | S027 | Human | Liver | HCC | 2.39e-12 | 4.93e-01 | 0.2446 |
| 51066 | SSUH2 | S028 | Human | Liver | HCC | 2.23e-23 | 7.01e-01 | 0.2503 |
| 51066 | SSUH2 | S029 | Human | Liver | HCC | 3.57e-22 | 6.64e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SSUH2 | SNV | Missense_Mutation | novel | c.877N>C | p.Tyr293His | p.Y293H | Q9Y2M2 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| SSUH2 | SNV | Missense_Mutation | novel | c.245C>T | p.Ala82Val | p.A82V | Q9Y2M2 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-D8-A3Z6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphane | SD |
| SSUH2 | SNV | Missense_Mutation | c.479A>C | p.Gln160Pro | p.Q160P | Q9Y2M2 | protein_coding | deleterious(0.04) | possibly_damaging(0.744) | TCGA-E9-A1NC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
| SSUH2 | insertion | Frame_Shift_Ins | novel | c.1067_1068insTGTGGCTGTTT | p.His357ValfsTer91 | p.H357Vfs*91 | Q9Y2M2 | protein_coding | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD | ||
| SSUH2 | insertion | In_Frame_Ins | novel | c.1066_1067insCGTCCTGTTTGC | p.Asp356delinsAlaSerCysLeuHis | p.D356delinsASCLH | Q9Y2M2 | protein_coding | TCGA-A2-A04V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD | ||
| SSUH2 | SNV | Missense_Mutation | novel | c.418N>T | p.Pro140Ser | p.P140S | Q9Y2M2 | protein_coding | deleterious(0.02) | probably_damaging(0.964) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| SSUH2 | SNV | Missense_Mutation | rs776971510 | c.322N>T | p.Arg108Trp | p.R108W | Q9Y2M2 | protein_coding | deleterious(0.02) | benign(0.019) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR |
| SSUH2 | SNV | Missense_Mutation | c.215N>A | p.Pro72His | p.P72H | Q9Y2M2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SSUH2 | SNV | Missense_Mutation | c.713N>T | p.Ala238Val | p.A238V | Q9Y2M2 | protein_coding | tolerated(0.13) | benign(0.306) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SSUH2 | SNV | Missense_Mutation | rs748228423 | c.218N>T | p.Ala73Val | p.A73V | Q9Y2M2 | protein_coding | tolerated(0.98) | benign(0) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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