Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SSU72

Gene summary for SSU72

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SSU72

Gene ID

29101

Gene nameSSU72 homolog, RNA polymerase II CTD phosphatase
Gene AliasHSPC182
Cytomap1p36.33
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q9NP77


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
29101SSU72HTA11_3410_2000001011HumanColorectumAD7.18e-041.92e-010.0155
29101SSU72HTA11_2487_2000001011HumanColorectumSER1.08e-064.06e-01-0.1808
29101SSU72HTA11_1938_2000001011HumanColorectumAD1.46e-146.43e-01-0.0811
29101SSU72HTA11_78_2000001011HumanColorectumAD5.26e-044.19e-01-0.1088
29101SSU72HTA11_347_2000001011HumanColorectumAD4.25e-205.82e-01-0.1954
29101SSU72HTA11_411_2000001011HumanColorectumSER7.46e-057.64e-01-0.2602
29101SSU72HTA11_2112_2000001011HumanColorectumSER2.11e-025.18e-01-0.2196
29101SSU72HTA11_3361_2000001011HumanColorectumAD3.56e-044.83e-01-0.1207
29101SSU72HTA11_83_2000001011HumanColorectumSER3.06e-045.07e-01-0.1526
29101SSU72HTA11_696_2000001011HumanColorectumAD6.59e-195.75e-01-0.1464
29101SSU72HTA11_866_2000001011HumanColorectumAD3.66e-063.19e-01-0.1001
29101SSU72HTA11_1391_2000001011HumanColorectumAD1.33e-167.26e-01-0.059
29101SSU72HTA11_2992_2000001011HumanColorectumSER6.69e-035.94e-01-0.1706
29101SSU72HTA11_5212_2000001011HumanColorectumAD3.39e-055.74e-01-0.2061
29101SSU72HTA11_5216_2000001011HumanColorectumSER4.55e-076.86e-01-0.1462
29101SSU72HTA11_546_2000001011HumanColorectumAD2.05e-043.66e-01-0.0842
29101SSU72HTA11_866_3004761011HumanColorectumAD8.84e-103.83e-010.096
29101SSU72HTA11_7696_3000711011HumanColorectumAD2.62e-022.50e-010.0674
29101SSU72HTA11_7469_2000001011HumanColorectumAD1.74e-036.11e-01-0.0124
29101SSU72HTA11_99999970781_79442HumanColorectumMSS7.40e-063.72e-010.294
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0016311ColorectumADdephosphorylation123/3918417/187231.84e-053.82e-04123
GO:0006470ColorectumADprotein dephosphorylation88/3918281/187232.56e-054.89e-0488
GO:00064701ColorectumSERprotein dephosphorylation65/2897281/187234.44e-046.51e-0365
GO:00163111ColorectumSERdephosphorylation86/2897417/187232.73e-032.46e-0286
GO:00064702ColorectumMSSprotein dephosphorylation73/3467281/187231.15e-031.12e-0273
GO:00163112ColorectumMSSdephosphorylation101/3467417/187231.98e-031.70e-02101
GO:000647017EsophagusHGINprotein dephosphorylation61/2587281/187231.86e-043.51e-0361
GO:00311243EsophagusHGINmRNA 3'-end processing18/258762/187231.37e-031.61e-0218
GO:001631110EsophagusESCCdephosphorylation251/8552417/187231.26e-092.99e-08251
GO:000647018EsophagusESCCprotein dephosphorylation177/8552281/187233.13e-096.72e-08177
GO:003112412EsophagusESCCmRNA 3'-end processing47/855262/187231.29e-061.58e-0547
GO:00311233EsophagusESCCRNA 3'-end processing76/8552116/187231.25e-051.15e-0476
GO:00063783EsophagusESCCmRNA polyadenylation33/855244/187237.30e-055.49e-0433
GO:00436313EsophagusESCCRNA polyadenylation33/855245/187231.54e-041.02e-0333
GO:00063532EsophagusESCCDNA-templated transcription, termination15/855221/187231.54e-024.96e-0215
GO:000647011LiverCirrhoticprotein dephosphorylation96/4634281/187232.32e-042.11e-0396
GO:001631111LiverCirrhoticdephosphorylation130/4634417/187231.58e-031.03e-02130
GO:0031123LiverCirrhoticRNA 3'-end processing42/4634116/187233.85e-032.10e-0242
GO:0031124LiverCirrhoticmRNA 3'-end processing25/463462/187234.90e-032.56e-0225
GO:00311241LiverHCCmRNA 3'-end processing50/795862/187238.44e-102.60e-0850
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa03015ColorectumADmRNA surveillance pathway35/209297/84657.95e-033.13e-022.00e-0235
hsa030151ColorectumADmRNA surveillance pathway35/209297/84657.95e-033.13e-022.00e-0235
hsa030159EsophagusHGINmRNA surveillance pathway30/138397/84652.48e-042.69e-032.14e-0330
hsa0301514EsophagusHGINmRNA surveillance pathway30/138397/84652.48e-042.69e-032.14e-0330
hsa0301524EsophagusESCCmRNA surveillance pathway72/420597/84656.12e-074.10e-062.10e-0672
hsa0301534EsophagusESCCmRNA surveillance pathway72/420597/84656.12e-074.10e-062.10e-0672
hsa030154LiverCirrhoticmRNA surveillance pathway46/253097/84651.92e-041.30e-038.03e-0446
hsa0301511LiverCirrhoticmRNA surveillance pathway46/253097/84651.92e-041.30e-038.03e-0446
hsa0301521LiverHCCmRNA surveillance pathway66/402097/84653.16e-051.88e-041.04e-0466
hsa0301531LiverHCCmRNA surveillance pathway66/402097/84653.16e-051.88e-041.04e-0466
hsa030158Oral cavityOSCCmRNA surveillance pathway75/370497/84651.30e-112.01e-101.02e-1075
hsa0301513Oral cavityOSCCmRNA surveillance pathway75/370497/84651.30e-112.01e-101.02e-1075
hsa0301523Oral cavityLPmRNA surveillance pathway50/241897/84651.39e-061.50e-059.66e-0650
hsa0301533Oral cavityLPmRNA surveillance pathway50/241897/84651.39e-061.50e-059.66e-0650
hsa030155ProstateBPHmRNA surveillance pathway32/171897/84652.20e-038.63e-035.34e-0332
hsa0301512ProstateBPHmRNA surveillance pathway32/171897/84652.20e-038.63e-035.34e-0332
hsa0301522ProstateTumormRNA surveillance pathway33/179197/84652.18e-038.60e-035.33e-0333
hsa0301532ProstateTumormRNA surveillance pathway33/179197/84652.18e-038.60e-035.33e-0333
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SSU72SNVMissense_Mutationnovelc.405C>Ap.His135Glnp.H135QQ9NP77protein_codingdeleterious(0)probably_damaging(1)TCGA-A2-A4S0-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SSU72SNVMissense_Mutationc.377G>Cp.Arg126Thrp.R126TQ9NP77protein_codingdeleterious(0.01)possibly_damaging(0.616)TCGA-C5-A902-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
SSU72SNVMissense_Mutationc.554G>Ap.Arg185Hisp.R185HQ9NP77protein_codingtolerated(0.28)possibly_damaging(0.775)TCGA-AA-3864-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
SSU72SNVMissense_Mutationrs751224426c.281G>Ap.Arg94Glnp.R94QQ9NP77protein_codingtolerated(0.41)benign(0.005)TCGA-CM-6674-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
SSU72insertionFrame_Shift_Insnovelc.245dupTp.Leu82PhefsTer8p.L82Ffs*8Q9NP77protein_codingTCGA-A6-5661-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
SSU72SNVMissense_Mutationnovelc.85N>Tp.Arg29Trpp.R29WQ9NP77protein_codingdeleterious(0)probably_damaging(0.97)TCGA-A5-A0GI-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
SSU72SNVMissense_Mutationnovelc.316G>Tp.Asp106Tyrp.D106YQ9NP77protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AJ-A3EK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIChemotherapycarboplatinCR
SSU72SNVMissense_Mutationnovelc.455C>Tp.Ala152Valp.A152VQ9NP77protein_codingdeleterious(0.01)benign(0.396)TCGA-AX-A1CE-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnspecificPaclitaxelSD
SSU72SNVMissense_Mutationnovelc.505G>Ap.Glu169Lysp.E169KQ9NP77protein_codingdeleterious(0)possibly_damaging(0.808)TCGA-AX-A2HD-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnknownUnknownSD
SSU72SNVMissense_Mutationc.554N>Ap.Arg185Hisp.R185HQ9NP77protein_codingtolerated(0.28)possibly_damaging(0.775)TCGA-EY-A1GD-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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