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Gene: SSSCA1 |
Gene summary for SSSCA1 |
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Gene information | Species | Human | Gene symbol | SSSCA1 | Gene ID | 10534 |
Gene name | zinc ribbon domain containing 2 | |
Gene Alias | SSSCA1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | G3V1B8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10534 | SSSCA1 | P1T-E | Human | Esophagus | ESCC | 1.73e-14 | 5.87e-01 | 0.0875 |
10534 | SSSCA1 | P2T-E | Human | Esophagus | ESCC | 3.41e-38 | 6.62e-01 | 0.1177 |
10534 | SSSCA1 | P4T-E | Human | Esophagus | ESCC | 7.01e-48 | 1.33e+00 | 0.1323 |
10534 | SSSCA1 | P5T-E | Human | Esophagus | ESCC | 1.73e-89 | 1.85e+00 | 0.1327 |
10534 | SSSCA1 | P8T-E | Human | Esophagus | ESCC | 2.72e-32 | 7.23e-01 | 0.0889 |
10534 | SSSCA1 | P9T-E | Human | Esophagus | ESCC | 1.65e-35 | 8.48e-01 | 0.1131 |
10534 | SSSCA1 | P10T-E | Human | Esophagus | ESCC | 2.20e-39 | 7.50e-01 | 0.116 |
10534 | SSSCA1 | P11T-E | Human | Esophagus | ESCC | 2.42e-19 | 9.22e-01 | 0.1426 |
10534 | SSSCA1 | P12T-E | Human | Esophagus | ESCC | 3.73e-20 | 5.44e-01 | 0.1122 |
10534 | SSSCA1 | P15T-E | Human | Esophagus | ESCC | 5.42e-30 | 6.57e-01 | 0.1149 |
10534 | SSSCA1 | P16T-E | Human | Esophagus | ESCC | 1.09e-33 | 5.66e-01 | 0.1153 |
10534 | SSSCA1 | P17T-E | Human | Esophagus | ESCC | 2.34e-29 | 1.41e+00 | 0.1278 |
10534 | SSSCA1 | P19T-E | Human | Esophagus | ESCC | 2.27e-15 | 1.28e+00 | 0.1662 |
10534 | SSSCA1 | P20T-E | Human | Esophagus | ESCC | 1.22e-21 | 3.71e-01 | 0.1124 |
10534 | SSSCA1 | P21T-E | Human | Esophagus | ESCC | 1.81e-74 | 1.52e+00 | 0.1617 |
10534 | SSSCA1 | P22T-E | Human | Esophagus | ESCC | 5.57e-20 | 4.92e-01 | 0.1236 |
10534 | SSSCA1 | P23T-E | Human | Esophagus | ESCC | 1.21e-52 | 1.33e+00 | 0.108 |
10534 | SSSCA1 | P24T-E | Human | Esophagus | ESCC | 1.78e-29 | 6.78e-01 | 0.1287 |
10534 | SSSCA1 | P26T-E | Human | Esophagus | ESCC | 4.61e-37 | 6.64e-01 | 0.1276 |
10534 | SSSCA1 | P27T-E | Human | Esophagus | ESCC | 3.38e-15 | 3.42e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSSCA1 | SNV | Missense_Mutation | c.455N>A | p.Cys152Tyr | p.C152Y | O60232 | protein_coding | tolerated(0.91) | benign(0.027) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SSSCA1 | SNV | Missense_Mutation | novel | c.247N>A | p.Asp83Asn | p.D83N | O60232 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SSSCA1 | SNV | Missense_Mutation | novel | c.310N>A | p.Ala104Thr | p.A104T | O60232 | protein_coding | tolerated(0.45) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SSSCA1 | SNV | Missense_Mutation | novel | c.85N>A | p.Glu29Lys | p.E29K | O60232 | protein_coding | deleterious(0) | possibly_damaging(0.572) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SSSCA1 | SNV | Missense_Mutation | novel | c.271G>A | p.Ala91Thr | p.A91T | O60232 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
SSSCA1 | SNV | Missense_Mutation | novel | c.277C>G | p.Leu93Val | p.L93V | O60232 | protein_coding | tolerated(0.22) | benign(0.151) | TCGA-AX-A1CN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Carboplatin | PD |
SSSCA1 | SNV | Missense_Mutation | novel | c.553N>T | p.Arg185Cys | p.R185C | O60232 | protein_coding | tolerated(0.05) | possibly_damaging(0.586) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SSSCA1 | SNV | Missense_Mutation | novel | c.461N>T | p.Gln154Leu | p.Q154L | O60232 | protein_coding | tolerated(0.23) | benign(0.173) | TCGA-EO-A3AU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SSSCA1 | SNV | Missense_Mutation | c.427G>C | p.Val143Leu | p.V143L | O60232 | protein_coding | tolerated(0.79) | benign(0) | TCGA-55-8620-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
SSSCA1 | SNV | Missense_Mutation | novel | c.82N>T | p.Arg28Trp | p.R28W | O60232 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CV-A6JZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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