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Gene: SSC5D |
Gene summary for SSC5D |
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Gene information | Species | Human | Gene symbol | SSC5D | Gene ID | 284297 |
Gene name | scavenger receptor cysteine rich family member with 5 domains | |
Gene Alias | S5D-SRCRB | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | A1L4H1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
284297 | SSC5D | ATC12 | Human | Thyroid | ATC | 5.96e-08 | 1.73e-01 | 0.34 |
284297 | SSC5D | ATC13 | Human | Thyroid | ATC | 4.23e-28 | 6.69e-01 | 0.34 |
284297 | SSC5D | ATC4 | Human | Thyroid | ATC | 1.06e-08 | 2.06e-01 | 0.34 |
284297 | SSC5D | ATC5 | Human | Thyroid | ATC | 1.13e-41 | 7.36e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSC5D | SNV | Missense_Mutation | novel | c.3556N>T | p.His1186Tyr | p.H1186Y | A1L4H1 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SSC5D | SNV | Missense_Mutation | c.772G>T | p.Gly258Trp | p.G258W | A1L4H1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
SSC5D | SNV | Missense_Mutation | novel | c.3812N>A | p.Pro1271His | p.P1271H | A1L4H1 | protein_coding | tolerated_low_confidence(0.06) | possibly_damaging(0.506) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD |
SSC5D | SNV | Missense_Mutation | rs760346179 | c.4192N>C | p.Thr1398Pro | p.T1398P | A1L4H1 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-BH-A0HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
SSC5D | SNV | Missense_Mutation | rs201038280 | c.3898N>T | p.His1300Tyr | p.H1300Y | A1L4H1 | protein_coding | tolerated_low_confidence(0.19) | benign(0.022) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
SSC5D | SNV | Missense_Mutation | c.2794N>T | p.Asp932Tyr | p.D932Y | A1L4H1 | protein_coding | deleterious_low_confidence(0) | benign(0.36) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSC5D | SNV | Missense_Mutation | rs558298468 | c.1580N>T | p.Ala527Val | p.A527V | A1L4H1 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-D8-A73U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
SSC5D | SNV | Missense_Mutation | rs529975420 | c.482N>A | p.Arg161His | p.R161H | A1L4H1 | protein_coding | tolerated(0.18) | benign(0) | TCGA-LL-A7T0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SSC5D | SNV | Missense_Mutation | novel | c.3952N>A | p.Asp1318Asn | p.D1318N | A1L4H1 | protein_coding | tolerated_low_confidence(0.74) | benign(0.005) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SSC5D | SNV | Missense_Mutation | novel | c.149N>G | p.Asp50Gly | p.D50G | A1L4H1 | protein_coding | deleterious(0.04) | probably_damaging(0.998) | TCGA-PL-A8LX-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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