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Gene: SSBP3 |
Gene summary for SSBP3 |
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Gene information | Species | Human | Gene symbol | SSBP3 | Gene ID | 23648 |
Gene name | single stranded DNA binding protein 3 | |
Gene Alias | CSDP | |
Cytomap | 1p32.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9BWW4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23648 | SSBP3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.43e-02 | -1.26e-01 | 0.0155 |
23648 | SSBP3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.68e-03 | -2.61e-01 | 0.3005 |
23648 | SSBP3 | A015-C-203 | Human | Colorectum | FAP | 2.04e-29 | -3.77e-01 | -0.1294 |
23648 | SSBP3 | A015-C-204 | Human | Colorectum | FAP | 7.33e-05 | -6.18e-02 | -0.0228 |
23648 | SSBP3 | A014-C-040 | Human | Colorectum | FAP | 9.56e-06 | -2.28e-01 | -0.1184 |
23648 | SSBP3 | A002-C-201 | Human | Colorectum | FAP | 1.17e-12 | -1.06e-01 | 0.0324 |
23648 | SSBP3 | A002-C-203 | Human | Colorectum | FAP | 2.62e-02 | -1.80e-02 | 0.2786 |
23648 | SSBP3 | A001-C-119 | Human | Colorectum | FAP | 1.27e-07 | -3.77e-01 | -0.1557 |
23648 | SSBP3 | A001-C-108 | Human | Colorectum | FAP | 2.19e-13 | -1.32e-01 | -0.0272 |
23648 | SSBP3 | A002-C-205 | Human | Colorectum | FAP | 6.62e-25 | -4.07e-01 | -0.1236 |
23648 | SSBP3 | A001-C-104 | Human | Colorectum | FAP | 6.55e-04 | -4.73e-02 | 0.0184 |
23648 | SSBP3 | A015-C-005 | Human | Colorectum | FAP | 2.19e-04 | -1.31e-01 | -0.0336 |
23648 | SSBP3 | A015-C-006 | Human | Colorectum | FAP | 6.38e-17 | -2.55e-01 | -0.0994 |
23648 | SSBP3 | A015-C-106 | Human | Colorectum | FAP | 1.02e-09 | -1.72e-01 | -0.0511 |
23648 | SSBP3 | A002-C-114 | Human | Colorectum | FAP | 1.33e-20 | -2.95e-01 | -0.1561 |
23648 | SSBP3 | A015-C-104 | Human | Colorectum | FAP | 1.04e-30 | -3.14e-01 | -0.1899 |
23648 | SSBP3 | A001-C-014 | Human | Colorectum | FAP | 1.83e-13 | -1.77e-01 | 0.0135 |
23648 | SSBP3 | A002-C-016 | Human | Colorectum | FAP | 2.18e-23 | -2.00e-01 | 0.0521 |
23648 | SSBP3 | A015-C-002 | Human | Colorectum | FAP | 4.67e-12 | -1.53e-01 | -0.0763 |
23648 | SSBP3 | A001-C-203 | Human | Colorectum | FAP | 5.65e-09 | 7.44e-03 | -0.0481 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
SSBP3 | ICAF | Thyroid | HT | KRT8,EXD3,TDO2, etc. | 2.73e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSBP3 | SNV | Missense_Mutation | c.908C>A | p.Pro303His | p.P303H | Q9BWW4 | protein_coding | deleterious(0.04) | probably_damaging(0.981) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
SSBP3 | SNV | Missense_Mutation | c.1024G>A | p.Gly342Arg | p.G342R | Q9BWW4 | protein_coding | deleterious(0.01) | possibly_damaging(0.595) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP3 | SNV | Missense_Mutation | c.464N>A | p.Arg155Gln | p.R155Q | Q9BWW4 | protein_coding | deleterious(0.02) | benign(0.358) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP3 | SNV | Missense_Mutation | c.1085G>A | p.Arg362Gln | p.R362Q | Q9BWW4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3979-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SSBP3 | SNV | Missense_Mutation | c.1024N>A | p.Gly342Arg | p.G342R | Q9BWW4 | protein_coding | deleterious(0.01) | possibly_damaging(0.595) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP3 | SNV | Missense_Mutation | c.134N>A | p.Arg45Gln | p.R45Q | Q9BWW4 | protein_coding | deleterious(0.02) | benign(0.145) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
SSBP3 | SNV | Missense_Mutation | c.134N>A | p.Arg45Gln | p.R45Q | Q9BWW4 | protein_coding | deleterious(0.02) | benign(0.145) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SSBP3 | SNV | Missense_Mutation | c.853G>A | p.Ala285Thr | p.A285T | Q9BWW4 | protein_coding | deleterious(0.04) | probably_damaging(0.928) | TCGA-G4-6626-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SSBP3 | SNV | Missense_Mutation | novel | c.1087N>T | p.Asp363Tyr | p.D363Y | Q9BWW4 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SSBP3 | SNV | Missense_Mutation | rs750379605 | c.397N>A | p.Ala133Thr | p.A133T | Q9BWW4 | protein_coding | tolerated(0.33) | benign(0.001) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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