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Gene: SSBP2 |
Gene summary for SSBP2 |
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Gene information | Species | Human | Gene symbol | SSBP2 | Gene ID | 23635 |
Gene name | single stranded DNA binding protein 2 | |
Gene Alias | HSPC116 | |
Cytomap | 5q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A087X159 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23635 | SSBP2 | CA_HPV_3 | Human | Cervix | CC | 1.03e-11 | 3.20e-01 | 0.0414 |
23635 | SSBP2 | CCI_1 | Human | Cervix | CC | 1.43e-03 | 7.19e-01 | 0.528 |
23635 | SSBP2 | CCI_2 | Human | Cervix | CC | 1.59e-22 | 2.83e+00 | 0.5249 |
23635 | SSBP2 | CCI_3 | Human | Cervix | CC | 3.64e-10 | 8.84e-01 | 0.516 |
23635 | SSBP2 | LZE4T | Human | Esophagus | ESCC | 9.81e-08 | -3.31e-04 | 0.0811 |
23635 | SSBP2 | LZE5T | Human | Esophagus | ESCC | 2.25e-02 | 3.95e-02 | 0.0514 |
23635 | SSBP2 | LZE7T | Human | Esophagus | ESCC | 2.13e-02 | 4.84e-02 | 0.0667 |
23635 | SSBP2 | LZE8T | Human | Esophagus | ESCC | 1.79e-19 | 3.85e-01 | 0.067 |
23635 | SSBP2 | LZE20T | Human | Esophagus | ESCC | 3.42e-04 | 1.29e-01 | 0.0662 |
23635 | SSBP2 | LZE22D1 | Human | Esophagus | HGIN | 6.46e-03 | -1.08e-03 | 0.0595 |
23635 | SSBP2 | LZE22T | Human | Esophagus | ESCC | 1.68e-02 | 3.95e-02 | 0.068 |
23635 | SSBP2 | LZE24T | Human | Esophagus | ESCC | 1.44e-21 | 4.51e-01 | 0.0596 |
23635 | SSBP2 | P1T-E | Human | Esophagus | ESCC | 1.07e-05 | 5.14e-01 | 0.0875 |
23635 | SSBP2 | P2T-E | Human | Esophagus | ESCC | 7.72e-23 | 5.02e-01 | 0.1177 |
23635 | SSBP2 | P4T-E | Human | Esophagus | ESCC | 1.47e-12 | 2.71e-01 | 0.1323 |
23635 | SSBP2 | P5T-E | Human | Esophagus | ESCC | 1.22e-10 | -1.42e-02 | 0.1327 |
23635 | SSBP2 | P8T-E | Human | Esophagus | ESCC | 3.12e-18 | 4.05e-01 | 0.0889 |
23635 | SSBP2 | P9T-E | Human | Esophagus | ESCC | 2.65e-08 | 1.96e-01 | 0.1131 |
23635 | SSBP2 | P10T-E | Human | Esophagus | ESCC | 4.84e-29 | 4.66e-01 | 0.116 |
23635 | SSBP2 | P11T-E | Human | Esophagus | ESCC | 5.98e-07 | 2.45e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SSBP2 | SNV | Missense_Mutation | novel | c.1071N>C | p.Gln357His | p.Q357H | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.978) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD | |
SSBP2 | SNV | Missense_Mutation | c.408N>C | p.Arg136Ser | p.R136S | protein_coding | deleterious(0.03) | benign(0.105) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | novel | c.866N>T | p.Arg289Ile | p.R289I | protein_coding | deleterious(0.01) | probably_damaging(0.929) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP2 | SNV | Missense_Mutation | novel | c.530N>T | p.Arg177Ile | p.R177I | protein_coding | deleterious(0.03) | probably_damaging(0.978) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SSBP2 | SNV | Missense_Mutation | c.882N>T | p.Met294Ile | p.M294I | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
SSBP2 | deletion | Frame_Shift_Del | novel | c.626delN | p.Asn209MetfsTer3 | p.N209Mfs*3 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
SSBP2 | SNV | Missense_Mutation | c.890N>T | p.Gly297Val | p.G297V | protein_coding | deleterious(0) | possibly_damaging(0.771) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | c.752N>T | p.Pro251Leu | p.P251L | protein_coding | deleterious(0.03) | possibly_damaging(0.477) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SSBP2 | SNV | Missense_Mutation | c.76N>A | p.Val26Ile | p.V26I | protein_coding | tolerated(0.05) | possibly_damaging(0.682) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
SSBP2 | SNV | Missense_Mutation | c.984N>G | p.Asn328Lys | p.N328K | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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