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Gene: SRP14-AS1 |
Gene summary for SRP14-AS1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SRP14-AS1 | Gene ID | 100131089 |
Gene name | SRP14 divergent transcript | |
Gene Alias | SRP14-AS1 | |
Cytomap | 15q15.1 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100131089 | SRP14-AS1 | HCC1_Meng | Human | Liver | HCC | 1.73e-16 | -3.50e-03 | 0.0246 |
100131089 | SRP14-AS1 | HCC1 | Human | Liver | HCC | 4.30e-11 | 3.00e+00 | 0.5336 |
100131089 | SRP14-AS1 | HCC2 | Human | Liver | HCC | 6.62e-09 | 1.63e+00 | 0.5341 |
100131089 | SRP14-AS1 | HCC5 | Human | Liver | HCC | 8.66e-05 | 1.08e+00 | 0.4932 |
100131089 | SRP14-AS1 | S014 | Human | Liver | HCC | 6.55e-07 | 2.64e-01 | 0.2254 |
100131089 | SRP14-AS1 | S015 | Human | Liver | HCC | 1.32e-04 | 2.90e-01 | 0.2375 |
100131089 | SRP14-AS1 | S016 | Human | Liver | HCC | 1.49e-03 | 2.01e-01 | 0.2243 |
100131089 | SRP14-AS1 | S028 | Human | Liver | HCC | 9.67e-07 | 3.30e-01 | 0.2503 |
100131089 | SRP14-AS1 | S029 | Human | Liver | HCC | 2.89e-04 | 3.25e-01 | 0.2581 |
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Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Liver | HCC: Hepatocellular carcinoma | |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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