Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SRD5A1

Gene summary for SRD5A1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SRD5A1

Gene ID

6715

Gene namesteroid 5 alpha-reductase 1
Gene AliasS5AR 1
Cytomap5p15.31
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

P18405


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6715SRD5A1LZE4THumanEsophagusESCC2.23e-061.56e-010.0811
6715SRD5A1LZE22THumanEsophagusESCC7.00e-064.33e-010.068
6715SRD5A1LZE24THumanEsophagusESCC7.10e-052.25e-010.0596
6715SRD5A1P1T-EHumanEsophagusESCC4.94e-139.69e-010.0875
6715SRD5A1P2T-EHumanEsophagusESCC7.08e-175.08e-010.1177
6715SRD5A1P4T-EHumanEsophagusESCC1.83e-154.34e-010.1323
6715SRD5A1P5T-EHumanEsophagusESCC3.80e-083.43e-010.1327
6715SRD5A1P8T-EHumanEsophagusESCC2.47e-132.14e-010.0889
6715SRD5A1P9T-EHumanEsophagusESCC1.14e-079.67e-020.1131
6715SRD5A1P10T-EHumanEsophagusESCC6.61e-173.04e-010.116
6715SRD5A1P11T-EHumanEsophagusESCC1.67e-083.35e-010.1426
6715SRD5A1P12T-EHumanEsophagusESCC3.31e-103.60e-010.1122
6715SRD5A1P15T-EHumanEsophagusESCC2.28e-071.14e-010.1149
6715SRD5A1P16T-EHumanEsophagusESCC3.87e-162.60e-010.1153
6715SRD5A1P17T-EHumanEsophagusESCC2.08e-106.32e-010.1278
6715SRD5A1P19T-EHumanEsophagusESCC3.28e-024.93e-010.1662
6715SRD5A1P20T-EHumanEsophagusESCC1.44e-541.36e+000.1124
6715SRD5A1P21T-EHumanEsophagusESCC1.57e-134.17e-010.1617
6715SRD5A1P22T-EHumanEsophagusESCC4.99e-112.52e-010.1236
6715SRD5A1P23T-EHumanEsophagusESCC4.13e-186.28e-010.108
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0006091110EsophagusESCCgeneration of precursor metabolites and energy331/8552490/187233.86e-238.45e-21331
GO:0022900110EsophagusESCCelectron transport chain133/8552175/187232.18e-161.67e-14133
GO:0071496111EsophagusESCCcellular response to external stimulus215/8552320/187234.29e-152.43e-13215
GO:190136118EsophagusESCCorganic cyclic compound catabolic process307/8552495/187239.99e-144.80e-12307
GO:0031668111EsophagusESCCcellular response to extracellular stimulus168/8552246/187234.93e-132.23e-11168
GO:0031669110EsophagusESCCcellular response to nutrient levels148/8552215/187234.58e-121.76e-10148
GO:0048732111EsophagusESCCgland development269/8552436/187237.81e-122.95e-10269
GO:0031667111EsophagusESCCresponse to nutrient levels289/8552474/187239.25e-123.47e-10289
GO:0009267110EsophagusESCCcellular response to starvation110/8552156/187232.63e-107.37e-09110
GO:004259419EsophagusESCCresponse to starvation133/8552197/187234.31e-101.14e-08133
GO:0048545111EsophagusESCCresponse to steroid hormone204/8552339/187234.47e-088.11e-07204
GO:0061458110EsophagusESCCreproductive system development247/8552427/187232.24e-073.42e-06247
GO:004860818EsophagusESCCreproductive structure development245/8552424/187232.82e-074.14e-06245
GO:0061008110EsophagusESCChepaticobiliary system development98/8552150/187238.91e-071.15e-0598
GO:0001889110EsophagusESCCliver development96/8552147/187231.18e-061.47e-0596
GO:0071383110EsophagusESCCcellular response to steroid hormone stimulus127/8552204/187231.26e-061.55e-05127
GO:190165319EsophagusESCCcellular response to peptide208/8552359/187231.68e-062.01e-05208
GO:0043434111EsophagusESCCresponse to peptide hormone234/8552414/187234.93e-065.21e-05234
GO:003286918EsophagusESCCcellular response to insulin stimulus124/8552203/187236.63e-066.75e-05124
GO:003286818EsophagusESCCresponse to insulin156/8552264/187237.21e-067.20e-05156
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SRD5A1SNVMissense_Mutationc.460N>Cp.Gly154Argp.G154RP18405protein_codingdeleterious(0)probably_damaging(1)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
SRD5A1SNVMissense_Mutationc.688N>Cp.Ser230Prop.S230PP18405protein_codingtolerated(0.2)benign(0.145)TCGA-BH-A0DG-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
SRD5A1SNVMissense_Mutationnovelc.408N>Ap.Ser136Argp.S136RP18405protein_codingdeleterious(0.01)possibly_damaging(0.463)TCGA-AA-3869-01Colorectumcolon adenocarcinomaMale>=65III/IVChemotherapycapecitabinePD
SRD5A1SNVMissense_Mutationc.353C>Tp.Thr118Ilep.T118IP18405protein_codingtolerated(0.29)benign(0)TCGA-AD-6889-01Colorectumcolon adenocarcinomaMale>=65I/IIChemotherapyxelodaPD
SRD5A1SNVMissense_Mutationc.613N>Ap.Glu205Lysp.E205KP18405protein_codingdeleterious(0.02)possibly_damaging(0.856)TCGA-AP-A051-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
SRD5A1SNVMissense_Mutationnovelc.721N>Tp.Leu241Phep.L241FP18405protein_codingdeleterious(0.02)probably_damaging(0.917)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
SRD5A1SNVMissense_Mutationc.758N>Gp.Ile253Serp.I253SP18405protein_codingtolerated(0.22)benign(0.065)TCGA-AX-A0J0-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
SRD5A1SNVMissense_Mutationrs374499334c.674N>Tp.Thr225Metp.T225MP18405protein_codingdeleterious(0)possibly_damaging(0.883)TCGA-BS-A0UV-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
SRD5A1SNVMissense_Mutationnovelc.759N>Gp.Ile253Metp.I253MP18405protein_codingtolerated(0.06)benign(0.222)TCGA-D1-A16X-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
SRD5A1SNVMissense_Mutationnovelc.286G>Tp.Gly96Trpp.G96WP18405protein_codingdeleterious(0.03)benign(0.014)TCGA-05-4396-01Lunglung adenocarcinomaMale>=65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6715SRD5A1DRUGGABLE GENOMELEVONORGESTRELLEVONORGESTREL
6715SRD5A1DRUGGABLE GENOMEDUTASTERIDEDUTASTERIDE
6715SRD5A1DRUGGABLE GENOMEBEXLOSTERIDEBEXLOSTERIDE
6715SRD5A1DRUGGABLE GENOMEFR-146687
6715SRD5A1DRUGGABLE GENOMEFINASTERIDEFINASTERIDE
6715SRD5A1DRUGGABLE GENOMELY-266111CHEMBL29166
6715SRD5A1DRUGGABLE GENOMEFINASTERIDEFINASTERIDE
6715SRD5A1DRUGGABLE GENOMEDUTASTERIDEDUTASTERIDE
6715SRD5A1DRUGGABLE GENOMEinhibitorCHEMBL1200969DUTASTERIDE
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