![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SPRYD4 |
Gene summary for SPRYD4 |
![]() |
Gene information | Species | Human | Gene symbol | SPRYD4 | Gene ID | 283377 |
Gene name | SPRY domain containing 4 | |
Gene Alias | SPRYD4 | |
Cytomap | 12q13.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q8WW59 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
283377 | SPRYD4 | LZE4T | Human | Esophagus | ESCC | 1.48e-04 | 1.99e-01 | 0.0811 |
283377 | SPRYD4 | LZE8T | Human | Esophagus | ESCC | 1.73e-02 | 1.34e-01 | 0.067 |
283377 | SPRYD4 | LZE24T | Human | Esophagus | ESCC | 2.46e-11 | 3.03e-01 | 0.0596 |
283377 | SPRYD4 | P2T-E | Human | Esophagus | ESCC | 2.17e-14 | 3.12e-01 | 0.1177 |
283377 | SPRYD4 | P4T-E | Human | Esophagus | ESCC | 2.56e-15 | 4.85e-01 | 0.1323 |
283377 | SPRYD4 | P5T-E | Human | Esophagus | ESCC | 4.24e-13 | 2.19e-01 | 0.1327 |
283377 | SPRYD4 | P8T-E | Human | Esophagus | ESCC | 5.76e-10 | 2.07e-01 | 0.0889 |
283377 | SPRYD4 | P9T-E | Human | Esophagus | ESCC | 8.04e-12 | 2.51e-01 | 0.1131 |
283377 | SPRYD4 | P10T-E | Human | Esophagus | ESCC | 4.25e-09 | 1.08e-01 | 0.116 |
283377 | SPRYD4 | P12T-E | Human | Esophagus | ESCC | 2.39e-13 | 2.44e-01 | 0.1122 |
283377 | SPRYD4 | P15T-E | Human | Esophagus | ESCC | 3.59e-11 | 2.97e-01 | 0.1149 |
283377 | SPRYD4 | P16T-E | Human | Esophagus | ESCC | 1.32e-13 | 1.87e-01 | 0.1153 |
283377 | SPRYD4 | P17T-E | Human | Esophagus | ESCC | 1.43e-08 | 4.09e-01 | 0.1278 |
283377 | SPRYD4 | P19T-E | Human | Esophagus | ESCC | 9.57e-03 | 4.29e-01 | 0.1662 |
283377 | SPRYD4 | P20T-E | Human | Esophagus | ESCC | 3.83e-15 | 3.62e-01 | 0.1124 |
283377 | SPRYD4 | P21T-E | Human | Esophagus | ESCC | 6.08e-23 | 5.02e-01 | 0.1617 |
283377 | SPRYD4 | P22T-E | Human | Esophagus | ESCC | 1.38e-13 | 2.58e-01 | 0.1236 |
283377 | SPRYD4 | P23T-E | Human | Esophagus | ESCC | 1.64e-16 | 4.16e-01 | 0.108 |
283377 | SPRYD4 | P24T-E | Human | Esophagus | ESCC | 7.97e-18 | 4.48e-01 | 0.1287 |
283377 | SPRYD4 | P26T-E | Human | Esophagus | ESCC | 9.35e-23 | 4.75e-01 | 0.1276 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPRYD4 | SNV | Missense_Mutation | c.199A>C | p.Asn67His | p.N67H | Q8WW59 | protein_coding | deleterious(0.02) | probably_damaging(0.964) | TCGA-E2-A14O-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | arimidex | SD | |
SPRYD4 | insertion | Nonsense_Mutation | novel | c.524_525insACCAGGCCTTAGCGTGGTTCACTGAGCCTGTGGAGGTT | p.Leu176ProfsTer8 | p.L176Pfs*8 | Q8WW59 | protein_coding | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SPRYD4 | SNV | Missense_Mutation | novel | c.427N>A | p.Glu143Lys | p.E143K | Q8WW59 | protein_coding | tolerated(0.74) | benign(0.007) | TCGA-MY-A5BD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SPRYD4 | SNV | Missense_Mutation | novel | c.75N>T | p.Glu25Asp | p.E25D | Q8WW59 | protein_coding | tolerated(0.61) | benign(0.001) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SPRYD4 | SNV | Missense_Mutation | novel | c.286N>T | p.Arg96Cys | p.R96C | Q8WW59 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SPRYD4 | SNV | Missense_Mutation | rs765472868 | c.187N>G | p.Lys63Glu | p.K63E | Q8WW59 | protein_coding | tolerated(0.36) | benign(0.355) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPRYD4 | SNV | Missense_Mutation | rs148775301 | c.23N>A | p.Ser8Tyr | p.S8Y | Q8WW59 | protein_coding | tolerated_low_confidence(1) | benign(0.094) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPRYD4 | SNV | Missense_Mutation | novel | c.316N>A | p.Asp106Asn | p.D106N | Q8WW59 | protein_coding | tolerated(0.34) | benign(0.154) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPRYD4 | SNV | Missense_Mutation | novel | c.166N>G | p.Leu56Val | p.L56V | Q8WW59 | protein_coding | tolerated(0.65) | benign(0.007) | TCGA-AJ-A3I9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
SPRYD4 | SNV | Missense_Mutation | novel | c.352N>A | p.Asp118Asn | p.D118N | Q8WW59 | protein_coding | tolerated(1) | benign(0.365) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |