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Gene: SPOUT1 |
Gene summary for SPOUT1 |
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Gene information | Species | Human | Gene symbol | SPOUT1 | Gene ID | 51490 |
Gene name | SPOUT domain containing methyltransferase 1 | |
Gene Alias | C9orf114 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5T280 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51490 | SPOUT1 | HCC1 | Human | Liver | HCC | 6.05e-05 | 2.30e+00 | 0.5336 |
51490 | SPOUT1 | HCC2 | Human | Liver | HCC | 1.13e-15 | 2.80e+00 | 0.5341 |
51490 | SPOUT1 | HCC5 | Human | Liver | HCC | 3.13e-06 | 2.02e+00 | 0.4932 |
51490 | SPOUT1 | S014 | Human | Liver | HCC | 1.51e-30 | 7.84e-01 | 0.2254 |
51490 | SPOUT1 | S015 | Human | Liver | HCC | 4.47e-24 | 9.41e-01 | 0.2375 |
51490 | SPOUT1 | S016 | Human | Liver | HCC | 4.21e-28 | 6.72e-01 | 0.2243 |
51490 | SPOUT1 | S027 | Human | Liver | HCC | 8.19e-05 | 3.47e-01 | 0.2446 |
51490 | SPOUT1 | S028 | Human | Liver | HCC | 1.76e-09 | 3.23e-01 | 0.2503 |
51490 | SPOUT1 | S029 | Human | Liver | HCC | 1.36e-14 | 4.19e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:005123521 | Liver | HCC | maintenance of location | 185/7958 | 327/18723 | 1.70e-07 | 3.12e-06 | 185 |
GO:003105021 | Liver | HCC | dsRNA processing | 38/7958 | 54/18723 | 3.15e-05 | 3.21e-04 | 38 |
GO:007091821 | Liver | HCC | production of small RNA involved in gene silencing by RNA | 38/7958 | 54/18723 | 3.15e-05 | 3.21e-04 | 38 |
GO:005165112 | Liver | HCC | maintenance of location in cell | 119/7958 | 214/18723 | 7.11e-05 | 6.39e-04 | 119 |
GO:003519621 | Liver | HCC | production of miRNAs involved in gene silencing by miRNA | 36/7958 | 52/18723 | 8.79e-05 | 7.66e-04 | 36 |
GO:0051657 | Liver | HCC | maintenance of organelle location | 9/7958 | 11/18723 | 9.51e-03 | 3.60e-02 | 9 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPOUT1 | SNV | Missense_Mutation | c.664N>C | p.Glu222Gln | p.E222Q | Q5T280 | protein_coding | tolerated(0.9) | benign(0.009) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
SPOUT1 | SNV | Missense_Mutation | c.397N>C | p.Gly133Arg | p.G133R | Q5T280 | protein_coding | tolerated(0.07) | benign(0.259) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SPOUT1 | SNV | Missense_Mutation | c.652N>A | p.Asp218Asn | p.D218N | Q5T280 | protein_coding | tolerated(0.07) | probably_damaging(0.993) | TCGA-BH-A18H-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
SPOUT1 | SNV | Missense_Mutation | novel | c.16A>T | p.Arg6Trp | p.R6W | Q5T280 | protein_coding | deleterious_low_confidence(0.01) | benign(0.103) | TCGA-DS-A7WH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SPOUT1 | SNV | Missense_Mutation | c.165N>C | p.Lys55Asn | p.K55N | Q5T280 | protein_coding | tolerated(0.22) | benign(0.154) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SPOUT1 | SNV | Missense_Mutation | novel | c.991G>A | p.Glu331Lys | p.E331K | Q5T280 | protein_coding | deleterious(0.04) | benign(0.324) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SPOUT1 | SNV | Missense_Mutation | c.278N>A | p.Arg93His | p.R93H | Q5T280 | protein_coding | deleterious(0.03) | benign(0.443) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SPOUT1 | SNV | Missense_Mutation | c.96N>T | p.Lys32Asn | p.K32N | Q5T280 | protein_coding | deleterious(0.02) | benign(0.118) | TCGA-AA-3976-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | |
SPOUT1 | SNV | Missense_Mutation | c.53G>T | p.Arg18Met | p.R18M | Q5T280 | protein_coding | deleterious(0.01) | benign(0.121) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
SPOUT1 | SNV | Missense_Mutation | rs746723809 | c.545G>A | p.Arg182His | p.R182H | Q5T280 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AU-6004-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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