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Gene: SPON1 |
Gene summary for SPON1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SPON1 | Gene ID | 10418 |
| Gene name | spondin 1 | |
| Gene Alias | VSGP/F-spondin | |
| Cytomap | 11p15.2 | |
| Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9HCB6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 10418 | SPON1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.28e-15 | -5.38e-01 | 0.0155 |
| 10418 | SPON1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.61e-09 | 5.67e-01 | -0.1954 |
| 10418 | SPON1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.01e-12 | -5.23e-01 | 0.096 |
| 10418 | SPON1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.33e-11 | -5.55e-01 | 0.0338 |
| 10418 | SPON1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.49e-17 | -5.31e-01 | 0.0674 |
| 10418 | SPON1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.06e-03 | -4.87e-01 | 0.0588 |
| 10418 | SPON1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.44e-17 | -5.11e-01 | 0.294 |
| 10418 | SPON1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.26e-15 | -5.04e-01 | 0.3859 |
| 10418 | SPON1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.24e-06 | -5.55e-01 | 0.2585 |
| 10418 | SPON1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.88e-20 | -5.37e-01 | 0.3005 |
| 10418 | SPON1 | F007 | Human | Colorectum | FAP | 4.62e-09 | -5.39e-01 | 0.1176 |
| 10418 | SPON1 | A002-C-010 | Human | Colorectum | FAP | 2.31e-20 | -5.35e-01 | 0.242 |
| 10418 | SPON1 | A001-C-207 | Human | Colorectum | FAP | 1.83e-05 | -4.14e-01 | 0.1278 |
| 10418 | SPON1 | A015-C-203 | Human | Colorectum | FAP | 1.26e-17 | -4.95e-01 | -0.1294 |
| 10418 | SPON1 | A015-C-204 | Human | Colorectum | FAP | 1.16e-09 | -4.72e-01 | -0.0228 |
| 10418 | SPON1 | A014-C-040 | Human | Colorectum | FAP | 3.75e-02 | -4.62e-01 | -0.1184 |
| 10418 | SPON1 | A002-C-201 | Human | Colorectum | FAP | 7.37e-19 | -5.29e-01 | 0.0324 |
| 10418 | SPON1 | A002-C-203 | Human | Colorectum | FAP | 8.86e-22 | -5.50e-01 | 0.2786 |
| 10418 | SPON1 | A001-C-119 | Human | Colorectum | FAP | 1.46e-13 | -5.55e-01 | -0.1557 |
| 10418 | SPON1 | A001-C-108 | Human | Colorectum | FAP | 5.33e-12 | -4.36e-01 | -0.0272 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
| GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
| GO:0051099 | Colorectum | AD | positive regulation of binding | 66/3918 | 173/18723 | 1.47e-07 | 6.64e-06 | 66 |
| GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
| GO:0032092 | Colorectum | AD | positive regulation of protein binding | 33/3918 | 85/18723 | 1.22e-04 | 1.78e-03 | 33 |
| GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
| GO:0016485 | Colorectum | AD | protein processing | 63/3918 | 225/18723 | 6.77e-03 | 4.19e-02 | 63 |
| GO:00458622 | Colorectum | MSS | positive regulation of proteolysis | 119/3467 | 372/18723 | 2.14e-10 | 2.09e-08 | 119 |
| GO:00510982 | Colorectum | MSS | regulation of binding | 113/3467 | 363/18723 | 3.55e-09 | 2.41e-07 | 113 |
| GO:00510992 | Colorectum | MSS | positive regulation of binding | 59/3467 | 173/18723 | 7.11e-07 | 2.53e-05 | 59 |
| GO:00433932 | Colorectum | MSS | regulation of protein binding | 62/3467 | 196/18723 | 6.44e-06 | 1.69e-04 | 62 |
| GO:00320921 | Colorectum | MSS | positive regulation of protein binding | 29/3467 | 85/18723 | 4.44e-04 | 5.32e-03 | 29 |
| GO:00516042 | Colorectum | MSS | protein maturation | 75/3467 | 294/18723 | 1.70e-03 | 1.53e-02 | 75 |
| GO:0034249 | Colorectum | MSS | negative regulation of cellular amide metabolic process | 70/3467 | 273/18723 | 2.07e-03 | 1.76e-02 | 70 |
| GO:00164852 | Colorectum | MSS | protein processing | 57/3467 | 225/18723 | 6.60e-03 | 4.38e-02 | 57 |
| GO:0050435 | Colorectum | MSS | amyloid-beta metabolic process | 21/3467 | 67/18723 | 7.90e-03 | 4.84e-02 | 21 |
| GO:00510984 | Colorectum | FAP | regulation of binding | 81/2622 | 363/18723 | 1.04e-05 | 2.97e-04 | 81 |
| GO:00458624 | Colorectum | FAP | positive regulation of proteolysis | 81/2622 | 372/18723 | 2.64e-05 | 6.08e-04 | 81 |
| GO:00510994 | Colorectum | FAP | positive regulation of binding | 44/2622 | 173/18723 | 4.52e-05 | 9.40e-04 | 44 |
| GO:00320923 | Colorectum | FAP | positive regulation of protein binding | 25/2622 | 85/18723 | 1.76e-04 | 2.62e-03 | 25 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SPON1 | SNV | Missense_Mutation | novel | c.494N>C | p.Gln165Pro | p.Q165P | Q9HCB6 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-A2-A0YD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
| SPON1 | SNV | Missense_Mutation | novel | c.1364N>C | p.Ser455Thr | p.S455T | Q9HCB6 | protein_coding | tolerated(0.1) | probably_damaging(0.995) | TCGA-A8-A07I-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
| SPON1 | SNV | Missense_Mutation | novel | c.791C>T | p.Ser264Leu | p.S264L | Q9HCB6 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SPON1 | SNV | Missense_Mutation | novel | c.651N>C | p.Glu217Asp | p.E217D | Q9HCB6 | protein_coding | tolerated(0.13) | possibly_damaging(0.726) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
| SPON1 | SNV | Missense_Mutation | novel | c.1513T>A | p.Ser505Thr | p.S505T | Q9HCB6 | protein_coding | tolerated(0.3) | benign(0.322) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |
| SPON1 | SNV | Missense_Mutation | novel | c.719N>G | p.Ser240Cys | p.S240C | Q9HCB6 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
| SPON1 | insertion | Nonsense_Mutation | novel | c.1045_1046insTCATTTGAAATTCACAGGAACCCTTTGGAGTAGACGT | p.Asp349ValfsTer3 | p.D349Vfs*3 | Q9HCB6 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
| SPON1 | SNV | Missense_Mutation | novel | c.781N>A | p.Glu261Lys | p.E261K | Q9HCB6 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C5-A7X5-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
| SPON1 | SNV | Missense_Mutation | rs782564186 | c.1552G>A | p.Gly518Ser | p.G518S | Q9HCB6 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
| SPON1 | SNV | Missense_Mutation | novel | c.2312N>A | p.Gly771Glu | p.G771E | Q9HCB6 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.666) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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