Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SPINT1

Gene summary for SPINT1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SPINT1

Gene ID

6692

Gene nameserine peptidase inhibitor, Kunitz type 1
Gene AliasHAI
Cytomap15q15.1
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

O43278


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6692SPINT1CA_HPV_1HumanCervixCC1.02e-04-2.44e-010.0264
6692SPINT1TumorHumanCervixCC2.16e-154.79e-010.1241
6692SPINT1sample3HumanCervixCC9.66e-255.62e-010.1387
6692SPINT1H2HumanCervixHSIL_HPV5.32e-165.76e-010.0632
6692SPINT1T3HumanCervixCC5.30e-225.53e-010.1389
6692SPINT1HTA11_3410_2000001011HumanColorectumAD4.60e-043.19e-010.0155
6692SPINT1HTA11_2487_2000001011HumanColorectumSER6.83e-231.15e+00-0.1808
6692SPINT1HTA11_1938_2000001011HumanColorectumAD1.73e-116.90e-01-0.0811
6692SPINT1HTA11_78_2000001011HumanColorectumAD3.54e-096.01e-01-0.1088
6692SPINT1HTA11_347_2000001011HumanColorectumAD4.26e-351.07e+00-0.1954
6692SPINT1HTA11_411_2000001011HumanColorectumSER5.45e-111.92e+00-0.2602
6692SPINT1HTA11_2112_2000001011HumanColorectumSER3.89e-051.02e+00-0.2196
6692SPINT1HTA11_3361_2000001011HumanColorectumAD1.55e-097.84e-01-0.1207
6692SPINT1HTA11_83_2000001011HumanColorectumSER9.97e-116.83e-01-0.1526
6692SPINT1HTA11_696_2000001011HumanColorectumAD6.78e-267.96e-01-0.1464
6692SPINT1HTA11_866_2000001011HumanColorectumAD2.63e-155.71e-01-0.1001
6692SPINT1HTA11_1391_2000001011HumanColorectumAD1.24e-178.62e-01-0.059
6692SPINT1HTA11_5212_2000001011HumanColorectumAD3.70e-131.09e+00-0.2061
6692SPINT1HTA11_5216_2000001011HumanColorectumSER9.98e-057.89e-01-0.1462
6692SPINT1HTA11_546_2000001011HumanColorectumAD1.05e-087.17e-01-0.0842
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005254710CervixCCregulation of peptidase activity112/2311461/187236.70e-133.08e-10112
GO:005254810CervixCCregulation of endopeptidase activity103/2311432/187231.89e-115.14e-09103
GO:004586110CervixCCnegative regulation of proteolysis80/2311351/187232.88e-081.98e-0680
GO:00513469CervixCCnegative regulation of hydrolase activity81/2311379/187234.27e-071.67e-0581
GO:00018908CervixCCplacenta development40/2311144/187234.59e-071.77e-0540
GO:00104669CervixCCnegative regulation of peptidase activity60/2311262/187231.27e-064.34e-0560
GO:00614588CervixCCreproductive system development87/2311427/187231.37e-064.55e-0587
GO:00486088CervixCCreproductive structure development86/2311424/187231.90e-065.97e-0586
GO:00107206CervixCCpositive regulation of cell development64/2311298/187235.69e-061.41e-0464
GO:001095110CervixCCnegative regulation of endopeptidase activity56/2311252/187237.43e-061.74e-0456
GO:00017018CervixCCin utero embryonic development71/2311367/187237.21e-051.00e-0371
GO:00018928CervixCCembryonic placenta development22/231182/187232.89e-043.12e-0322
GO:00519603CervixCCregulation of nervous system development77/2311443/187231.13e-039.30e-0377
GO:00507676CervixCCregulation of neurogenesis65/2311364/187231.33e-031.05e-0265
GO:00351487CervixCCtube formation31/2311148/187232.07e-031.51e-0231
GO:00507694CervixCCpositive regulation of neurogenesis43/2311225/187232.25e-031.61e-0243
GO:00018417CervixCCneural tube formation23/2311102/187232.80e-031.87e-0223
GO:00606696CervixCCembryonic placenta morphogenesis9/231126/187232.85e-031.90e-029
GO:00607136CervixCClabyrinthine layer morphogenesis8/231122/187233.43e-032.22e-028
GO:00605626CervixCCepithelial tube morphogenesis57/2311325/187233.79e-032.41e-0257
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa052157CervixCCProstate cancer27/126797/84657.54e-043.39e-032.01e-0327
hsa0521512CervixCCProstate cancer27/126797/84657.54e-043.39e-032.01e-0327
hsa05215ColorectumADProstate cancer35/209297/84657.95e-033.13e-022.00e-0235
hsa052151ColorectumADProstate cancer35/209297/84657.95e-033.13e-022.00e-0235
hsa052152ColorectumFAPProstate cancer28/140497/84651.67e-038.57e-035.21e-0328
hsa05202ColorectumFAPTranscriptional misregulation in cancer45/1404193/84659.19e-033.33e-022.03e-0245
hsa052153ColorectumFAPProstate cancer28/140497/84651.67e-038.57e-035.21e-0328
hsa052021ColorectumFAPTranscriptional misregulation in cancer45/1404193/84659.19e-033.33e-022.03e-0245
hsa0521516EsophagusESCCProstate cancer72/420597/84656.12e-074.10e-062.10e-0672
hsa052028EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0521517EsophagusESCCProstate cancer72/420597/84656.12e-074.10e-062.10e-0672
hsa0520213EsophagusESCCTranscriptional misregulation in cancer116/4205193/84652.08e-035.95e-033.05e-03116
hsa0521510Oral cavityOSCCProstate cancer66/370497/84651.05e-065.89e-063.00e-0666
hsa0521515Oral cavityOSCCProstate cancer66/370497/84651.05e-065.89e-063.00e-0666
hsa0521524Oral cavityEOLPProstate cancer31/121897/84657.90e-064.73e-052.79e-0531
hsa0521534Oral cavityEOLPProstate cancer31/121897/84657.90e-064.73e-052.79e-0531
hsa0521542Oral cavityNEOLPProstate cancer28/111297/84653.15e-052.57e-041.62e-0428
hsa0521552Oral cavityNEOLPProstate cancer28/111297/84653.15e-052.57e-041.62e-0428
hsa052159ProstateBPHProstate cancer48/171897/84651.08e-101.87e-091.16e-0948
hsa052027ProstateBPHTranscriptional misregulation in cancer53/1718193/84659.56e-032.92e-021.81e-0253
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SPINT1SNVMissense_Mutationnovelc.529G>Ap.Glu177Lysp.E177KO43278protein_codingdeleterious(0.03)benign(0.038)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SPINT1SNVMissense_Mutationc.562N>Tp.Asp188Tyrp.D188YO43278protein_codingdeleterious(0.02)probably_damaging(0.915)TCGA-E2-A1LA-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
SPINT1insertionNonsense_Mutationnovelc.1318_1319insAGTTTAp.Ser440delinsTerp.S440delins*O43278protein_codingTCGA-AN-A03X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SPINT1insertionFrame_Shift_Insnovelc.1321_1322insTTGTGCCTACAGTTATTp.Cys441PhefsTer18p.C441Ffs*18O43278protein_codingTCGA-AN-A03X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SPINT1deletionFrame_Shift_Delnovelc.1547delNp.Asp516AlafsTer155p.D516Afs*155O43278protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
SPINT1SNVMissense_Mutationc.1552N>Ap.Glu518Lysp.E518KO43278protein_codingdeleterious(0.04)probably_damaging(0.994)TCGA-UC-A7PF-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
SPINT1SNVMissense_Mutationnovelc.1004N>Ap.Cys335Tyrp.C335YO43278protein_codingdeleterious(0)probably_damaging(0.993)TCGA-VS-A8EL-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
SPINT1SNVMissense_Mutationrs751324782c.1103N>Tp.Ala368Valp.A368VO43278protein_codingtolerated(0.43)benign(0.031)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
SPINT1SNVMissense_Mutationc.1525T>Ap.Ser509Thrp.S509TO43278protein_codingtolerated(0.19)possibly_damaging(0.452)TCGA-AZ-6598-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
SPINT1SNVMissense_Mutationc.1310G>Ap.Cys437Tyrp.C437YO43278protein_codingdeleterious(0)probably_damaging(1)TCGA-CK-4951-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
6692SPINT1PROTEASE INHIBITOR, DRUGGABLE GENOMESURAMINSURAMIN15590895
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