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Gene: SPATC1L |
Gene summary for SPATC1L |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SPATC1L | Gene ID | 84221 |
| Gene name | spermatogenesis and centriole associated 1 like | |
| Gene Alias | C21orf56 | |
| Cytomap | 21q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9H0A9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84221 | SPATC1L | LZE4T | Human | Esophagus | ESCC | 1.46e-04 | 1.76e-01 | 0.0811 |
| 84221 | SPATC1L | LZE24T | Human | Esophagus | ESCC | 2.02e-05 | 1.45e-01 | 0.0596 |
| 84221 | SPATC1L | P2T-E | Human | Esophagus | ESCC | 4.62e-19 | 3.79e-01 | 0.1177 |
| 84221 | SPATC1L | P4T-E | Human | Esophagus | ESCC | 2.04e-33 | 7.43e-01 | 0.1323 |
| 84221 | SPATC1L | P5T-E | Human | Esophagus | ESCC | 1.15e-15 | 2.84e-01 | 0.1327 |
| 84221 | SPATC1L | P8T-E | Human | Esophagus | ESCC | 1.43e-16 | 1.39e-01 | 0.0889 |
| 84221 | SPATC1L | P9T-E | Human | Esophagus | ESCC | 1.85e-15 | 3.61e-01 | 0.1131 |
| 84221 | SPATC1L | P10T-E | Human | Esophagus | ESCC | 5.32e-21 | 4.22e-01 | 0.116 |
| 84221 | SPATC1L | P11T-E | Human | Esophagus | ESCC | 3.94e-13 | 3.81e-01 | 0.1426 |
| 84221 | SPATC1L | P12T-E | Human | Esophagus | ESCC | 4.58e-21 | 4.80e-01 | 0.1122 |
| 84221 | SPATC1L | P15T-E | Human | Esophagus | ESCC | 7.42e-10 | 2.06e-01 | 0.1149 |
| 84221 | SPATC1L | P16T-E | Human | Esophagus | ESCC | 4.54e-34 | 5.61e-01 | 0.1153 |
| 84221 | SPATC1L | P17T-E | Human | Esophagus | ESCC | 7.41e-09 | 3.96e-01 | 0.1278 |
| 84221 | SPATC1L | P19T-E | Human | Esophagus | ESCC | 1.81e-04 | 3.88e-01 | 0.1662 |
| 84221 | SPATC1L | P21T-E | Human | Esophagus | ESCC | 2.55e-34 | 6.62e-01 | 0.1617 |
| 84221 | SPATC1L | P22T-E | Human | Esophagus | ESCC | 2.76e-07 | 1.87e-01 | 0.1236 |
| 84221 | SPATC1L | P23T-E | Human | Esophagus | ESCC | 7.92e-12 | 3.66e-01 | 0.108 |
| 84221 | SPATC1L | P24T-E | Human | Esophagus | ESCC | 6.04e-17 | 3.26e-01 | 0.1287 |
| 84221 | SPATC1L | P26T-E | Human | Esophagus | ESCC | 8.32e-38 | 6.10e-01 | 0.1276 |
| 84221 | SPATC1L | P27T-E | Human | Esophagus | ESCC | 3.90e-27 | 4.74e-01 | 0.1055 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:007190016 | Esophagus | ESCC | regulation of protein serine/threonine kinase activity | 227/8552 | 359/18723 | 1.12e-11 | 4.10e-10 | 227 |
| GO:000701527 | Esophagus | ESCC | actin filament organization | 259/8552 | 442/18723 | 2.37e-08 | 4.50e-07 | 259 |
| GO:00719029 | Esophagus | ESCC | positive regulation of protein serine/threonine kinase activity | 124/8552 | 200/18723 | 2.27e-06 | 2.61e-05 | 124 |
| GO:004586018 | Esophagus | ESCC | positive regulation of protein kinase activity | 219/8552 | 386/18723 | 6.91e-06 | 6.97e-05 | 219 |
| GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
| GO:000815420 | Esophagus | ESCC | actin polymerization or depolymerization | 130/8552 | 218/18723 | 2.19e-05 | 1.88e-04 | 130 |
| GO:000701522 | Liver | HCC | actin filament organization | 252/7958 | 442/18723 | 3.83e-10 | 1.25e-08 | 252 |
| GO:000815422 | Liver | HCC | actin polymerization or depolymerization | 130/7958 | 218/18723 | 2.31e-07 | 4.14e-06 | 130 |
| GO:007190021 | Liver | HCC | regulation of protein serine/threonine kinase activity | 189/7958 | 359/18723 | 5.97e-05 | 5.47e-04 | 189 |
| GO:004586021 | Liver | HCC | positive regulation of protein kinase activity | 194/7958 | 386/18723 | 1.16e-03 | 6.54e-03 | 194 |
| GO:003367411 | Liver | HCC | positive regulation of kinase activity | 230/7958 | 467/18723 | 1.72e-03 | 8.95e-03 | 230 |
| GO:007190010 | Oral cavity | OSCC | regulation of protein serine/threonine kinase activity | 201/7305 | 359/18723 | 3.90e-11 | 1.27e-09 | 201 |
| GO:000701520 | Oral cavity | OSCC | actin filament organization | 230/7305 | 442/18723 | 1.37e-08 | 2.77e-07 | 230 |
| GO:004586016 | Oral cavity | OSCC | positive regulation of protein kinase activity | 194/7305 | 386/18723 | 3.90e-06 | 4.59e-05 | 194 |
| GO:000815418 | Oral cavity | OSCC | actin polymerization or depolymerization | 117/7305 | 218/18723 | 7.38e-06 | 8.04e-05 | 117 |
| GO:003367418 | Oral cavity | OSCC | positive regulation of kinase activity | 228/7305 | 467/18723 | 8.31e-06 | 8.90e-05 | 228 |
| GO:00719028 | Oral cavity | OSCC | positive regulation of protein serine/threonine kinase activity | 107/7305 | 200/18723 | 2.12e-05 | 2.02e-04 | 107 |
| GO:0007015110 | Oral cavity | LP | actin filament organization | 143/4623 | 442/18723 | 1.44e-04 | 1.65e-03 | 143 |
| GO:007190015 | Oral cavity | LP | regulation of protein serine/threonine kinase activity | 119/4623 | 359/18723 | 1.70e-04 | 1.90e-03 | 119 |
| GO:000815419 | Oral cavity | LP | actin polymerization or depolymerization | 76/4623 | 218/18723 | 4.67e-04 | 4.42e-03 | 76 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SPATC1L | SNV | Missense_Mutation | rs766419736 | c.875N>A | p.Arg292His | p.R292H | Q9H0A9 | protein_coding | tolerated(0.39) | possibly_damaging(0.818) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| SPATC1L | SNV | Missense_Mutation | novel | c.84N>A | p.Asn28Lys | p.N28K | Q9H0A9 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
| SPATC1L | SNV | Missense_Mutation | c.465N>C | p.Met155Ile | p.M155I | Q9H0A9 | protein_coding | tolerated(0.4) | benign(0) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SPATC1L | SNV | Missense_Mutation | c.626C>T | p.Ala209Val | p.A209V | Q9H0A9 | protein_coding | deleterious(0) | benign(0.391) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SPATC1L | SNV | Missense_Mutation | c.718N>A | p.Gly240Ser | p.G240S | Q9H0A9 | protein_coding | deleterious(0.05) | benign(0.04) | TCGA-DM-A28C-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| SPATC1L | SNV | Missense_Mutation | c.562N>A | p.Gly188Ser | p.G188S | Q9H0A9 | protein_coding | tolerated(0.45) | benign(0.007) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SPATC1L | SNV | Missense_Mutation | c.538C>G | p.Leu180Val | p.L180V | Q9H0A9 | protein_coding | tolerated(0.11) | probably_damaging(0.992) | TCGA-EI-6885-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+5-fu | PD | |
| SPATC1L | SNV | Missense_Mutation | novel | c.868G>A | p.Asp290Asn | p.D290N | Q9H0A9 | protein_coding | tolerated(0.13) | benign(0.034) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| SPATC1L | deletion | Frame_Shift_Del | rs755647414 | c.286delC | p.Leu96CysfsTer42 | p.L96Cfs*42 | Q9H0A9 | protein_coding | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
| SPATC1L | SNV | Missense_Mutation | c.392G>T | p.Arg131Met | p.R131M | Q9H0A9 | protein_coding | deleterious(0) | benign(0.41) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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