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Gene: SPATA20 |
Gene summary for SPATA20 |
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Gene information | Species | Human | Gene symbol | SPATA20 | Gene ID | 64847 |
Gene name | spermatogenesis associated 20 | |
Gene Alias | HEL-S-98 | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8TB22 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64847 | SPATA20 | LZE2T | Human | Esophagus | ESCC | 2.97e-02 | 3.32e-01 | 0.082 |
64847 | SPATA20 | LZE4T | Human | Esophagus | ESCC | 1.11e-11 | 2.71e-01 | 0.0811 |
64847 | SPATA20 | LZE7T | Human | Esophagus | ESCC | 1.30e-09 | 2.84e-01 | 0.0667 |
64847 | SPATA20 | LZE20T | Human | Esophagus | ESCC | 8.25e-03 | 7.05e-02 | 0.0662 |
64847 | SPATA20 | LZE22T | Human | Esophagus | ESCC | 9.50e-04 | 2.25e-01 | 0.068 |
64847 | SPATA20 | LZE24T | Human | Esophagus | ESCC | 1.30e-22 | 5.51e-01 | 0.0596 |
64847 | SPATA20 | LZE22D3 | Human | Esophagus | HGIN | 2.07e-02 | 3.58e-01 | 0.0653 |
64847 | SPATA20 | LZE21T | Human | Esophagus | ESCC | 7.12e-03 | 2.17e-01 | 0.0655 |
64847 | SPATA20 | P1T-E | Human | Esophagus | ESCC | 4.89e-14 | 7.92e-01 | 0.0875 |
64847 | SPATA20 | P2T-E | Human | Esophagus | ESCC | 9.43e-19 | 3.48e-01 | 0.1177 |
64847 | SPATA20 | P4T-E | Human | Esophagus | ESCC | 1.67e-20 | 4.14e-01 | 0.1323 |
64847 | SPATA20 | P5T-E | Human | Esophagus | ESCC | 3.81e-18 | 3.39e-01 | 0.1327 |
64847 | SPATA20 | P8T-E | Human | Esophagus | ESCC | 3.75e-29 | 5.66e-01 | 0.0889 |
64847 | SPATA20 | P9T-E | Human | Esophagus | ESCC | 4.71e-21 | 3.75e-01 | 0.1131 |
64847 | SPATA20 | P10T-E | Human | Esophagus | ESCC | 4.52e-27 | 5.20e-01 | 0.116 |
64847 | SPATA20 | P11T-E | Human | Esophagus | ESCC | 1.48e-14 | 5.47e-01 | 0.1426 |
64847 | SPATA20 | P12T-E | Human | Esophagus | ESCC | 3.51e-40 | 7.81e-01 | 0.1122 |
64847 | SPATA20 | P15T-E | Human | Esophagus | ESCC | 6.87e-28 | 5.87e-01 | 0.1149 |
64847 | SPATA20 | P16T-E | Human | Esophagus | ESCC | 1.36e-28 | 5.51e-01 | 0.1153 |
64847 | SPATA20 | P17T-E | Human | Esophagus | ESCC | 6.69e-04 | 2.17e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPATA20 | SNV | Missense_Mutation | novel | c.575N>T | p.Pro192Leu | p.P192L | Q8TB22 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2683-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | irinotecan | PD |
SPATA20 | SNV | Missense_Mutation | c.1664N>C | p.Leu555Pro | p.L555P | Q8TB22 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATA20 | SNV | Missense_Mutation | novel | c.1584G>T | p.Met528Ile | p.M528I | Q8TB22 | protein_coding | deleterious(0.05) | possibly_damaging(0.82) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPATA20 | SNV | Missense_Mutation | c.1127N>C | p.Val376Ala | p.V376A | Q8TB22 | protein_coding | deleterious(0.04) | benign(0.152) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
SPATA20 | SNV | Missense_Mutation | rs752772922 | c.2122N>T | p.Arg708Cys | p.R708C | Q8TB22 | protein_coding | tolerated(0.21) | benign(0.011) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SPATA20 | SNV | Missense_Mutation | c.1943N>G | p.Leu648Arg | p.L648R | Q8TB22 | protein_coding | deleterious(0) | possibly_damaging(0.616) | TCGA-D5-6922-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SPATA20 | SNV | Missense_Mutation | c.1789G>A | p.Val597Met | p.V597M | Q8TB22 | protein_coding | deleterious(0) | possibly_damaging(0.454) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SPATA20 | SNV | Missense_Mutation | c.500A>G | p.Tyr167Cys | p.Y167C | Q8TB22 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPATA20 | SNV | Missense_Mutation | rs368022155 | c.1019N>A | p.Arg340His | p.R340H | Q8TB22 | protein_coding | tolerated(0.11) | benign(0.15) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
SPATA20 | SNV | Missense_Mutation | rs766371817 | c.2090N>A | p.Arg697His | p.R697H | Q8TB22 | protein_coding | tolerated(0.13) | benign(0.015) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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