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Gene: SPANXB1 |
Gene summary for SPANXB1 |
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Gene information | Species | Human | Gene symbol | SPANXB1 | Gene ID | 728695 |
Gene name | SPANX family member B1 | |
Gene Alias | B1 | |
Cytomap | Xq27.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9NS25 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
728695 | SPANXB1 | ATC09 | Human | Thyroid | ATC | 1.19e-36 | 1.88e+00 | 0.2871 |
728695 | SPANXB1 | ATC1 | Human | Thyroid | ATC | 2.72e-36 | 2.08e+00 | 0.2878 |
728695 | SPANXB1 | ATC4 | Human | Thyroid | ATC | 6.21e-03 | 1.45e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPANXB1 | SNV | Missense_Mutation | novel | c.89N>T | p.Thr30Met | p.T30M | Q9NS25 | protein_coding | tolerated_low_confidence(0.12) | benign(0.003) | TCGA-BH-A0C7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
SPANXB1 | insertion | Frame_Shift_Ins | novel | c.219_220insGTGAT | p.Leu74ValfsTer3 | p.L74Vfs*3 | Q9NS25 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SPANXB1 | SNV | Missense_Mutation | novel | c.232N>A | p.Ala78Thr | p.A78T | Q9NS25 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.982) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SPANXB1 | SNV | Missense_Mutation | novel | c.200N>A | p.Arg67Lys | p.R67K | Q9NS25 | protein_coding | tolerated_low_confidence(1) | benign(0.148) | TCGA-A6-5659-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SPANXB1 | SNV | Missense_Mutation | novel | c.239N>G | p.Glu80Gly | p.E80G | Q9NS25 | protein_coding | tolerated_low_confidence(0.07) | benign(0.402) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SPANXB1 | SNV | Missense_Mutation | novel | c.40N>T | p.Val14Phe | p.V14F | Q9NS25 | protein_coding | deleterious_low_confidence(0.02) | possibly_damaging(0.736) | TCGA-CK-4952-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SPANXB1 | SNV | Missense_Mutation | novel | c.277N>G | p.Phe93Val | p.F93V | Q9NS25 | protein_coding | tolerated_low_confidence(0.36) | benign(0) | TCGA-F4-6855-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPANXB1 | SNV | Missense_Mutation | novel | c.58N>A | p.Glu20Lys | p.E20K | Q9NS25 | protein_coding | tolerated_low_confidence(0.15) | probably_damaging(0.956) | TCGA-EI-6509-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
SPANXB1 | SNV | Missense_Mutation | novel | c.200N>T | p.Arg67Ile | p.R67I | Q9NS25 | protein_coding | tolerated_low_confidence(0.2) | benign(0.001) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPANXB1 | SNV | Missense_Mutation | novel | c.200N>T | p.Arg67Ile | p.R67I | Q9NS25 | protein_coding | tolerated_low_confidence(0.2) | benign(0.001) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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