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Gene: SPAM1 |
Gene summary for SPAM1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SPAM1 | Gene ID | 6677 |
| Gene name | sperm adhesion molecule 1 | |
| Gene Alias | HEL-S-96n | |
| Cytomap | 7q31.32 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P38567 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 6677 | SPAM1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.40e-02 | 1.93e-01 | 0.0216 |
| 6677 | SPAM1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.59e-07 | 2.54e-01 | -0.0811 |
| 6677 | SPAM1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.08e-06 | 3.67e-01 | -0.2196 |
| 6677 | SPAM1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.91e-05 | 1.80e-01 | -0.1207 |
| 6677 | SPAM1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.75e-18 | 3.51e-01 | -0.1464 |
| 6677 | SPAM1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.36e-06 | 1.40e-01 | -0.1001 |
| 6677 | SPAM1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.60e-11 | 2.68e-01 | -0.059 |
| 6677 | SPAM1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.09e-02 | 1.89e-01 | -0.1706 |
| 6677 | SPAM1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.16e-07 | 3.01e-01 | -0.2061 |
| 6677 | SPAM1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.15e-01 | -0.1462 |
| 6677 | SPAM1 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.78e-03 | 1.84e-01 | -0.0842 |
| 6677 | SPAM1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.15e-02 | 1.58e-01 | 0.0588 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0007009 | Colorectum | SER | plasma membrane organization | 36/2897 | 142/18723 | 1.50e-03 | 1.62e-02 | 36 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
| hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SPAM1 | SNV | Missense_Mutation | c.239G>A | p.Arg80Gln | p.R80Q | P38567 | protein_coding | tolerated(0.49) | benign(0.073) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SPAM1 | SNV | Missense_Mutation | c.571N>A | p.Glu191Lys | p.E191K | P38567 | protein_coding | deleterious(0.03) | benign(0.338) | TCGA-AR-A24Q-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| SPAM1 | SNV | Missense_Mutation | rs778917104 | c.353N>C | p.Ile118Thr | p.I118T | P38567 | protein_coding | tolerated(0.33) | benign(0.005) | TCGA-LL-A6FR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
| SPAM1 | SNV | Missense_Mutation | novel | c.1101N>G | p.Ile367Met | p.I367M | P38567 | protein_coding | deleterious(0.02) | possibly_damaging(0.779) | TCGA-LL-A73Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
| SPAM1 | deletion | Frame_Shift_Del | c.848delN | p.Glu284LysfsTer23 | p.E284Kfs*23 | P38567 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
| SPAM1 | SNV | Missense_Mutation | rs532636427 | c.836N>A | p.Arg279His | p.R279H | P38567 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| SPAM1 | SNV | Missense_Mutation | c.1273N>T | p.Asp425Tyr | p.D425Y | P38567 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| SPAM1 | SNV | Missense_Mutation | rs781017782 | c.979G>A | p.Glu327Lys | p.E327K | P38567 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| SPAM1 | SNV | Missense_Mutation | c.389A>T | p.Asp130Val | p.D130V | P38567 | protein_coding | deleterious(0) | possibly_damaging(0.686) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SPAM1 | SNV | Missense_Mutation | c.904G>A | p.Ala302Thr | p.A302T | P38567 | protein_coding | deleterious(0.02) | benign(0.012) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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