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Gene: SP5 |
Gene summary for SP5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SP5 | Gene ID | 389058 |
| Gene name | Sp5 transcription factor | |
| Gene Alias | SP5 | |
| Cytomap | 2q31.1 | |
| Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q6BEB4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 389058 | SP5 | HCC1 | Human | Liver | HCC | 9.85e-15 | 2.88e+00 | 0.5336 |
| 389058 | SP5 | S014 | Human | Liver | HCC | 6.33e-35 | 1.32e+00 | 0.2254 |
| 389058 | SP5 | S015 | Human | Liver | HCC | 1.35e-46 | 1.82e+00 | 0.2375 |
| 389058 | SP5 | S016 | Human | Liver | HCC | 1.32e-57 | 1.71e+00 | 0.2243 |
| 389058 | SP5 | S027 | Human | Liver | HCC | 2.57e-02 | 1.91e-01 | 0.2446 |
| 389058 | SP5 | S028 | Human | Liver | HCC | 1.64e-05 | 2.28e-01 | 0.2503 |
| 389058 | SP5 | S029 | Human | Liver | HCC | 2.14e-02 | 1.35e-01 | 0.2581 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00709979 | Breast | Precancer | neuron death | 50/1080 | 361/18723 | 7.75e-09 | 5.70e-07 | 50 |
| GO:00514029 | Breast | Precancer | neuron apoptotic process | 38/1080 | 246/18723 | 2.68e-08 | 1.75e-06 | 38 |
| GO:00096126 | Breast | Precancer | response to mechanical stimulus | 23/1080 | 216/18723 | 3.41e-03 | 2.85e-02 | 23 |
| GO:007099714 | Breast | IDC | neuron death | 57/1434 | 361/18723 | 1.31e-07 | 7.38e-06 | 57 |
| GO:005140213 | Breast | IDC | neuron apoptotic process | 42/1434 | 246/18723 | 7.21e-07 | 3.35e-05 | 42 |
| GO:000961211 | Breast | IDC | response to mechanical stimulus | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
| GO:00423912 | Breast | IDC | regulation of membrane potential | 49/1434 | 434/18723 | 4.04e-03 | 3.25e-02 | 49 |
| GO:00015082 | Breast | IDC | action potential | 19/1434 | 134/18723 | 6.62e-03 | 4.62e-02 | 19 |
| GO:007099724 | Breast | DCIS | neuron death | 57/1390 | 361/18723 | 4.56e-08 | 2.84e-06 | 57 |
| GO:005140222 | Breast | DCIS | neuron apoptotic process | 43/1390 | 246/18723 | 1.16e-07 | 6.13e-06 | 43 |
| GO:000961221 | Breast | DCIS | response to mechanical stimulus | 32/1390 | 216/18723 | 1.36e-04 | 2.33e-03 | 32 |
| GO:00423911 | Breast | DCIS | regulation of membrane potential | 47/1390 | 434/18723 | 5.87e-03 | 4.20e-02 | 47 |
| GO:00064708 | Cervix | CC | protein dephosphorylation | 60/2311 | 281/18723 | 1.33e-05 | 2.68e-04 | 60 |
| GO:00096127 | Cervix | CC | response to mechanical stimulus | 48/2311 | 216/18723 | 3.23e-05 | 5.29e-04 | 48 |
| GO:00073695 | Cervix | CC | gastrulation | 42/2311 | 185/18723 | 5.83e-05 | 8.46e-04 | 42 |
| GO:007099710 | Cervix | CC | neuron death | 70/2311 | 361/18723 | 7.50e-05 | 1.03e-03 | 70 |
| GO:005140210 | Cervix | CC | neuron apoptotic process | 49/2311 | 246/18723 | 4.48e-04 | 4.48e-03 | 49 |
| GO:00074923 | Cervix | CC | endoderm development | 20/2311 | 77/18723 | 8.40e-04 | 7.30e-03 | 20 |
| GO:00434099 | Cervix | CC | negative regulation of MAPK cascade | 37/2311 | 180/18723 | 1.17e-03 | 9.50e-03 | 37 |
| GO:00163117 | Cervix | CC | dephosphorylation | 73/2311 | 417/18723 | 1.23e-03 | 9.87e-03 | 73 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| SP5 | INCAF | Cervix | CC | HHIP-AS1,QPCT,BHLHE41, etc. | 3.10e-01 |  |
| SP5 | STM | Colorectum | AD | APCDD1,NKD1,AC007277.3, etc. | 1.42e-01 |  |
| SP5 | STM | Colorectum | MSI-H | APCDD1,NKD1,AC007277.3, etc. | 7.10e-02 |  |
| SP5 | STM | Colorectum | MSS | APCDD1,NKD1,AC007277.3, etc. | 2.61e-01 |  |
| SP5 | STM | Colorectum | SER | APCDD1,NKD1,AC007277.3, etc. | 7.45e-02 |  |
| SP5 | TUF | Colorectum | SER | APCDD1,NKD1,AC007277.3, etc. | 5.04e-02 | |
| SP5 | ICAF | Esophagus | ADJ | PTGDS,RGN,FGF10, etc. | 3.00e-01 |  |
| SP5 | FIB | Esophagus | ADJ | PTGDS,RGN,FGF10, etc. | 9.62e-03 | |
| SP5 | INCAF | Esophagus | Healthy | PTGDS,RGN,FGF10, etc. | 3.02e-02 |  |
| SP5 | ICAF | Esophagus | Healthy | PTGDS,RGN,FGF10, etc. | 1.55e-01 | |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 2 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SP5 | SNV | Missense_Mutation | c.1057N>A | p.Glu353Lys | p.E353K | Q6BEB4 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SP5 | SNV | Missense_Mutation | c.1015C>T | p.Arg339Cys | p.R339C | Q6BEB4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
| SP5 | SNV | Missense_Mutation | rs779921916 | c.910G>A | p.Gly304Ser | p.G304S | Q6BEB4 | protein_coding | deleterious(0.01) | benign(0.059) | TCGA-CI-6621-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
| SP5 | insertion | Frame_Shift_Ins | novel | c.784_785insC | p.Leu264ProfsTer118 | p.L264Pfs*118 | Q6BEB4 | protein_coding | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| SP5 | insertion | Frame_Shift_Ins | novel | c.58_59insC | p.Ser22GlnfsTer20 | p.S22Qfs*20 | Q6BEB4 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
| SP5 | SNV | Missense_Mutation | novel | c.1032N>T | p.Gln344His | p.Q344H | Q6BEB4 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| SP5 | SNV | Missense_Mutation | novel | c.1005G>T | p.Lys335Asn | p.K335N | Q6BEB4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SP5 | SNV | Missense_Mutation | c.1081N>C | p.Cys361Arg | p.C361R | Q6BEB4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8302-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| SP5 | SNV | Missense_Mutation | c.1052N>A | p.Thr351Lys | p.T351K | Q6BEB4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-51-4079-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SP5 | SNV | Missense_Mutation | novel | c.257N>G | p.Pro86Arg | p.P86R | Q6BEB4 | protein_coding | tolerated(0.2) | benign(0.033) | TCGA-68-A59J-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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