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Gene: SP110 |
Gene summary for SP110 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SP110 | Gene ID | 3431 |
Gene name | SP110 nuclear body protein | |
Gene Alias | IFI41 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9HB58 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3431 | SP110 | LZE4T | Human | Esophagus | ESCC | 3.47e-14 | 4.85e-01 | 0.0811 |
3431 | SP110 | LZE5T | Human | Esophagus | ESCC | 1.92e-04 | 3.33e-01 | 0.0514 |
3431 | SP110 | LZE7T | Human | Esophagus | ESCC | 1.97e-05 | 2.37e-01 | 0.0667 |
3431 | SP110 | LZE8T | Human | Esophagus | ESCC | 1.19e-03 | 1.82e-01 | 0.067 |
3431 | SP110 | LZE20T | Human | Esophagus | ESCC | 5.71e-14 | 3.98e-01 | 0.0662 |
3431 | SP110 | LZE22D1 | Human | Esophagus | HGIN | 1.91e-04 | 2.26e-01 | 0.0595 |
3431 | SP110 | LZE22T | Human | Esophagus | ESCC | 8.97e-03 | 2.51e-01 | 0.068 |
3431 | SP110 | LZE24T | Human | Esophagus | ESCC | 7.62e-33 | 1.09e+00 | 0.0596 |
3431 | SP110 | LZE21T | Human | Esophagus | ESCC | 5.27e-04 | 3.36e-01 | 0.0655 |
3431 | SP110 | LZE6T | Human | Esophagus | ESCC | 1.43e-07 | 4.61e-01 | 0.0845 |
3431 | SP110 | P1T-E | Human | Esophagus | ESCC | 6.84e-05 | 4.96e-01 | 0.0875 |
3431 | SP110 | P2T-E | Human | Esophagus | ESCC | 1.06e-27 | 5.12e-01 | 0.1177 |
3431 | SP110 | P4T-E | Human | Esophagus | ESCC | 5.90e-05 | 1.86e-01 | 0.1323 |
3431 | SP110 | P5T-E | Human | Esophagus | ESCC | 1.70e-08 | 1.74e-01 | 0.1327 |
3431 | SP110 | P8T-E | Human | Esophagus | ESCC | 9.66e-27 | 4.73e-01 | 0.0889 |
3431 | SP110 | P9T-E | Human | Esophagus | ESCC | 6.08e-17 | 4.65e-01 | 0.1131 |
3431 | SP110 | P10T-E | Human | Esophagus | ESCC | 2.17e-05 | 5.32e-02 | 0.116 |
3431 | SP110 | P11T-E | Human | Esophagus | ESCC | 4.12e-26 | 9.96e-01 | 0.1426 |
3431 | SP110 | P12T-E | Human | Esophagus | ESCC | 4.31e-12 | 2.28e-01 | 0.1122 |
3431 | SP110 | P15T-E | Human | Esophagus | ESCC | 1.62e-15 | 3.76e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SP110 | SNV | Missense_Mutation | rs868540504 | c.2134N>T | p.Leu712Phe | p.L712F | Q9HB58 | protein_coding | tolerated_low_confidence(0.72) | benign(0.011) | TCGA-A2-A0YG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
SP110 | SNV | Missense_Mutation | c.406N>A | p.Pro136Thr | p.P136T | Q9HB58 | protein_coding | tolerated(0.18) | benign(0.059) | TCGA-A2-A0YG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
SP110 | SNV | Missense_Mutation | c.958N>G | p.Gln320Glu | p.Q320E | Q9HB58 | protein_coding | tolerated(0.36) | benign(0.444) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SP110 | SNV | Missense_Mutation | rs200928586 | c.1579G>A | p.Glu527Lys | p.E527K | Q9HB58 | protein_coding | tolerated(1) | benign(0.013) | TCGA-AC-A2QI-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cytoxan | CR |
SP110 | SNV | Missense_Mutation | c.470N>A | p.Ser157Asn | p.S157N | Q9HB58 | protein_coding | tolerated(0.18) | benign(0.011) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
SP110 | deletion | Frame_Shift_Del | novel | c.896delN | p.Gly299GlufsTer33 | p.G299Efs*33 | Q9HB58 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SP110 | SNV | Missense_Mutation | c.1973C>T | p.Ala658Val | p.A658V | Q9HB58 | protein_coding | tolerated(0.09) | possibly_damaging(0.62) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SP110 | SNV | Missense_Mutation | c.1013N>T | p.Ala338Val | p.A338V | Q9HB58 | protein_coding | tolerated(0.14) | possibly_damaging(0.878) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SP110 | SNV | Missense_Mutation | c.850N>G | p.Ile284Val | p.I284V | Q9HB58 | protein_coding | tolerated(0.2) | benign(0.007) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SP110 | SNV | Missense_Mutation | c.1208N>G | p.Thr403Ser | p.T403S | Q9HB58 | protein_coding | tolerated(0.14) | probably_damaging(0.986) | TCGA-RU-A8FL-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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