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Gene: SOWAHA |
Gene summary for SOWAHA |
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Gene information | Species | Human | Gene symbol | SOWAHA | Gene ID | 134548 |
Gene name | sosondowah ankyrin repeat domain family member A | |
Gene Alias | ANKRD43 | |
Cytomap | 5q31.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
134548 | SOWAHA | HCC1 | Human | Liver | HCC | 5.16e-13 | 3.53e+00 | 0.5336 |
134548 | SOWAHA | HCC2 | Human | Liver | HCC | 1.32e-03 | 1.33e+00 | 0.5341 |
134548 | SOWAHA | S014 | Human | Liver | HCC | 4.58e-05 | 1.74e-01 | 0.2254 |
134548 | SOWAHA | S015 | Human | Liver | HCC | 2.18e-03 | 1.44e-01 | 0.2375 |
134548 | SOWAHA | S016 | Human | Liver | HCC | 1.41e-08 | 2.32e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOWAHA | SNV | Missense_Mutation | rs763068818 | c.1220G>A | p.Arg407His | p.R407H | Q2M3V2 | protein_coding | tolerated(0.11) | possibly_damaging(0.641) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
SOWAHA | deletion | Frame_Shift_Del | novel | c.282delN | p.Pro96ArgfsTer75 | p.P96Rfs*75 | Q2M3V2 | protein_coding | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SOWAHA | deletion | Frame_Shift_Del | c.292delG | p.Ala98GlnfsTer73 | p.A98Qfs*73 | Q2M3V2 | protein_coding | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
SOWAHA | SNV | Missense_Mutation | rs141507307 | c.1393N>A | p.Val465Ile | p.V465I | Q2M3V2 | protein_coding | tolerated(0.15) | probably_damaging(0.979) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
SOWAHA | SNV | Missense_Mutation | novel | c.1622T>C | p.Leu541Pro | p.L541P | Q2M3V2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
SOWAHA | SNV | Missense_Mutation | novel | c.1327N>A | p.Leu443Met | p.L443M | Q2M3V2 | protein_coding | deleterious(0.01) | probably_damaging(0.951) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOWAHA | SNV | Missense_Mutation | novel | c.1595N>A | p.Arg532Gln | p.R532Q | Q2M3V2 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOWAHA | SNV | Missense_Mutation | novel | c.1444N>A | p.Val482Ile | p.V482I | Q2M3V2 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AX-A0IZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOWAHA | SNV | Missense_Mutation | novel | c.1352N>T | p.Ala451Val | p.A451V | Q2M3V2 | protein_coding | tolerated(0.23) | benign(0.009) | TCGA-AX-A2HA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOWAHA | SNV | Missense_Mutation | novel | c.1405G>A | p.Ala469Thr | p.A469T | Q2M3V2 | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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