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Gene: SNORC |
Gene summary for SNORC |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SNORC | Gene ID | 389084 |
| Gene name | secondary ossification center associated regulator of chondrocyte maturation | |
| Gene Alias | ASCL830 | |
| Cytomap | 2q37.1 | |
| Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q6UX34 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 389084 | SNORC | GSM4909282 | Human | Breast | IDC | 8.02e-08 | -3.98e-01 | -0.0288 |
| 389084 | SNORC | GSM4909285 | Human | Breast | IDC | 5.14e-12 | -4.45e-01 | 0.21 |
| 389084 | SNORC | GSM4909286 | Human | Breast | IDC | 3.82e-83 | 1.21e+00 | 0.1081 |
| 389084 | SNORC | GSM4909288 | Human | Breast | IDC | 6.44e-10 | 8.91e-01 | 0.0988 |
| 389084 | SNORC | GSM4909290 | Human | Breast | IDC | 6.20e-09 | -4.53e-01 | 0.2096 |
| 389084 | SNORC | GSM4909294 | Human | Breast | IDC | 6.64e-11 | -4.04e-01 | 0.2022 |
| 389084 | SNORC | GSM4909296 | Human | Breast | IDC | 1.74e-13 | -4.47e-01 | 0.1524 |
| 389084 | SNORC | GSM4909297 | Human | Breast | IDC | 7.70e-10 | -4.26e-01 | 0.1517 |
| 389084 | SNORC | GSM4909298 | Human | Breast | IDC | 7.29e-07 | -3.65e-01 | 0.1551 |
| 389084 | SNORC | GSM4909299 | Human | Breast | IDC | 2.02e-42 | 9.86e-01 | 0.035 |
| 389084 | SNORC | GSM4909300 | Human | Breast | IDC | 4.09e-02 | 2.76e-01 | 0.0334 |
| 389084 | SNORC | GSM4909301 | Human | Breast | IDC | 1.15e-13 | -4.39e-01 | 0.1577 |
| 389084 | SNORC | GSM4909302 | Human | Breast | IDC | 2.66e-07 | -4.25e-01 | 0.1545 |
| 389084 | SNORC | GSM4909304 | Human | Breast | IDC | 5.38e-10 | -4.35e-01 | 0.1636 |
| 389084 | SNORC | GSM4909306 | Human | Breast | IDC | 5.00e-07 | -4.06e-01 | 0.1564 |
| 389084 | SNORC | GSM4909308 | Human | Breast | IDC | 2.98e-11 | -4.53e-01 | 0.158 |
| 389084 | SNORC | GSM4909309 | Human | Breast | IDC | 1.28e-05 | 4.48e-01 | 0.0483 |
| 389084 | SNORC | GSM4909311 | Human | Breast | IDC | 3.25e-07 | -2.19e-01 | 0.1534 |
| 389084 | SNORC | GSM4909312 | Human | Breast | IDC | 4.24e-13 | -4.37e-01 | 0.1552 |
| 389084 | SNORC | GSM4909315 | Human | Breast | IDC | 2.43e-11 | -4.38e-01 | 0.21 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Breast |  | IDC: Invasive ductal carcinoma |
| DCIS: Ductal carcinoma in situ | ||
| Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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