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Gene: SNORA76 |
Gene summary for SNORA76 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SNORA76 | Gene ID | 677842 |
| Gene name | small nucleolar RNA, H/ACA box 50C | |
| Gene Alias | ACA62 | |
| Cytomap | 17q23.3 | |
| Gene Type | snoRNA | GO ID | GO:0006139 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 677842 | SNORA76 | Pt13.a | Human | Liver | HCC | 2.38e-29 | 5.75e-01 | 0.021 |
| 677842 | SNORA76 | Pt13.b | Human | Liver | HCC | 9.91e-43 | 5.81e-01 | 0.0251 |
| 677842 | SNORA76 | Pt13.c | Human | Liver | HCC | 6.80e-09 | 4.51e-01 | 0.0076 |
| 677842 | SNORA76 | Pt14.a | Human | Liver | HCC | 2.30e-47 | 1.66e+00 | 0.0169 |
| 677842 | SNORA76 | Pt14.b | Human | Liver | HCC | 2.29e-41 | 1.07e+00 | 0.018 |
| 677842 | SNORA76 | Pt14.c | Human | Liver | HCC | 4.88e-25 | 1.13e+00 | 0.0054 |
| 677842 | SNORA76 | Pt14.d | Human | Liver | HCC | 4.36e-70 | 1.04e+00 | 0.0143 |
| 677842 | SNORA76 | P1_cSCC | Human | Skin | cSCC | 1.43e-43 | 1.02e+00 | 0.0292 |
| 677842 | SNORA76 | P2_cSCC | Human | Skin | cSCC | 1.96e-46 | 8.63e-01 | -0.024 |
| 677842 | SNORA76 | P4_cSCC | Human | Skin | cSCC | 6.06e-05 | 1.52e-01 | -0.00290000000000005 |
| 677842 | SNORA76 | P10_cSCC | Human | Skin | cSCC | 1.79e-14 | 3.22e-01 | 0.1017 |
| 677842 | SNORA76 | NAG_1 | Human | Stomach | CSG | 2.24e-02 | 2.02e-01 | -0.3534 |
| 677842 | SNORA76 | NAG_2 | Human | Stomach | CSG | 2.20e-02 | 1.94e-01 | -0.3324 |
| 677842 | SNORA76 | NAG_3 | Human | Stomach | CSG | 6.94e-04 | 2.93e-01 | -0.2816 |
| 677842 | SNORA76 | CAG_1 | Human | Stomach | CAG | 4.09e-07 | 5.22e-01 | -0.3206 |
| 677842 | SNORA76 | CAG_2 | Human | Stomach | CAG | 3.52e-02 | 1.67e-01 | -0.2831 |
| 677842 | SNORA76 | CAG_3 | Human | Stomach | CAG | 1.76e-22 | 5.70e-01 | -0.2766 |
| 677842 | SNORA76 | WIM_1 | Human | Stomach | WIM | 5.01e-17 | 6.18e-01 | 0.0335 |
| 677842 | SNORA76 | WIM_2 | Human | Stomach | WIM | 2.33e-16 | 6.77e-01 | 0.1159 |
| 677842 | SNORA76 | SIM_1 | Human | Stomach | SIM | 3.11e-14 | 4.26e-01 | 0.3573 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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