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Gene: SNIP1 |
Gene summary for SNIP1 |
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Gene information | Species | Human | Gene symbol | SNIP1 | Gene ID | 79753 |
Gene name | Smad nuclear interacting protein 1 | |
Gene Alias | PML1 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000375 | UniProtAcc | B1AK66 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79753 | SNIP1 | HCC1_Meng | Human | Liver | HCC | 5.33e-22 | -6.19e-03 | 0.0246 |
79753 | SNIP1 | HCC2_Meng | Human | Liver | HCC | 1.32e-02 | 2.93e-03 | 0.0107 |
79753 | SNIP1 | HCC1 | Human | Liver | HCC | 4.77e-05 | 2.43e+00 | 0.5336 |
79753 | SNIP1 | HCC2 | Human | Liver | HCC | 8.69e-08 | 1.75e+00 | 0.5341 |
79753 | SNIP1 | HCC5 | Human | Liver | HCC | 1.72e-13 | 2.04e+00 | 0.4932 |
79753 | SNIP1 | S014 | Human | Liver | HCC | 8.14e-04 | 2.47e-01 | 0.2254 |
79753 | SNIP1 | S015 | Human | Liver | HCC | 2.64e-06 | 3.68e-01 | 0.2375 |
79753 | SNIP1 | S016 | Human | Liver | HCC | 2.12e-04 | 2.51e-01 | 0.2243 |
79753 | SNIP1 | S028 | Human | Liver | HCC | 7.73e-13 | 5.40e-01 | 0.2503 |
79753 | SNIP1 | S029 | Human | Liver | HCC | 1.11e-09 | 5.38e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000838022 | Liver | HCC | RNA splicing | 313/7958 | 434/18723 | 1.36e-36 | 1.73e-33 | 313 |
GO:000037522 | Liver | HCC | RNA splicing, via transesterification reactions | 228/7958 | 324/18723 | 1.47e-24 | 4.06e-22 | 228 |
GO:000037722 | Liver | HCC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000039822 | Liver | HCC | mRNA splicing, via spliceosome | 224/7958 | 320/18723 | 1.16e-23 | 2.62e-21 | 224 |
GO:000724912 | Liver | HCC | I-kappaB kinase/NF-kappaB signaling | 156/7958 | 281/18723 | 6.66e-06 | 8.00e-05 | 156 |
GO:003105021 | Liver | HCC | dsRNA processing | 38/7958 | 54/18723 | 3.15e-05 | 3.21e-04 | 38 |
GO:007091821 | Liver | HCC | production of small RNA involved in gene silencing by RNA | 38/7958 | 54/18723 | 3.15e-05 | 3.21e-04 | 38 |
GO:003519621 | Liver | HCC | production of miRNAs involved in gene silencing by miRNA | 36/7958 | 52/18723 | 8.79e-05 | 7.66e-04 | 36 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNIP1 | SNV | Missense_Mutation | c.841T>C | p.Tyr281His | p.Y281H | Q8TAD8 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNIP1 | insertion | Frame_Shift_Ins | novel | c.975_976insGTGTTTTTCTTTTGGGGCGAACCCCTGAGCAGAGAATCTTACTA | p.Pro326ValfsTer29 | p.P326Vfs*29 | Q8TAD8 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SNIP1 | insertion | Frame_Shift_Ins | novel | c.556_557insTAATTTTTGTATTTTTAGTAGA | p.Arg186LeufsTer16 | p.R186Lfs*16 | Q8TAD8 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SNIP1 | insertion | Frame_Shift_Ins | novel | c.554_555insCACACCCA | p.Arg185SerfsTer61 | p.R185Sfs*61 | Q8TAD8 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
SNIP1 | SNV | Missense_Mutation | c.700N>C | p.Glu234Gln | p.E234Q | Q8TAD8 | protein_coding | deleterious(0.02) | benign(0.183) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
SNIP1 | SNV | Missense_Mutation | rs746110236 | c.757N>T | p.Arg253Cys | p.R253C | Q8TAD8 | protein_coding | deleterious(0.01) | benign(0.174) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
SNIP1 | SNV | Missense_Mutation | c.772N>T | p.Arg258Trp | p.R258W | Q8TAD8 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SNIP1 | SNV | Missense_Mutation | novel | c.478N>A | p.Gly160Arg | p.G160R | Q8TAD8 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNIP1 | SNV | Missense_Mutation | c.649G>A | p.Glu217Lys | p.E217K | Q8TAD8 | protein_coding | tolerated(0.23) | benign(0.005) | TCGA-AA-3971-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | CR | |
SNIP1 | SNV | Missense_Mutation | novel | c.202N>C | p.Asn68His | p.N68H | Q8TAD8 | protein_coding | tolerated_low_confidence(0.15) | benign(0.135) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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