Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SMURF2

Gene summary for SMURF2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SMURF2

Gene ID

64750

Gene nameSMAD specific E3 ubiquitin protein ligase 2
Gene AliasSMURF2
Cytomap17q23.3-q24.1
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

Q96DE7


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
64750SMURF2LZE4THumanEsophagusESCC8.35e-055.84e-020.0811
64750SMURF2LZE5THumanEsophagusESCC5.63e-042.59e-010.0514
64750SMURF2LZE7THumanEsophagusESCC2.19e-061.27e-010.0667
64750SMURF2LZE22THumanEsophagusESCC6.86e-042.04e-010.068
64750SMURF2LZE24THumanEsophagusESCC6.83e-132.93e-010.0596
64750SMURF2P1T-EHumanEsophagusESCC1.52e-025.52e-010.0875
64750SMURF2P2T-EHumanEsophagusESCC9.97e-141.18e-010.1177
64750SMURF2P4T-EHumanEsophagusESCC9.22e-034.66e-030.1323
64750SMURF2P5T-EHumanEsophagusESCC1.07e-03-3.62e-030.1327
64750SMURF2P8T-EHumanEsophagusESCC8.87e-102.56e-010.0889
64750SMURF2P9T-EHumanEsophagusESCC1.37e-121.30e-010.1131
64750SMURF2P10T-EHumanEsophagusESCC1.24e-141.49e-010.116
64750SMURF2P11T-EHumanEsophagusESCC3.91e-084.11e-010.1426
64750SMURF2P12T-EHumanEsophagusESCC1.41e-051.60e-010.1122
64750SMURF2P15T-EHumanEsophagusESCC1.22e-071.59e-010.1149
64750SMURF2P16T-EHumanEsophagusESCC5.81e-095.83e-020.1153
64750SMURF2P17T-EHumanEsophagusESCC1.38e-035.37e-020.1278
64750SMURF2P20T-EHumanEsophagusESCC8.08e-031.70e-020.1124
64750SMURF2P21T-EHumanEsophagusESCC3.18e-058.88e-020.1617
64750SMURF2P22T-EHumanEsophagusESCC5.97e-096.14e-020.1236
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0010498111EsophagusESCCproteasomal protein catabolic process369/8552490/187231.13e-411.80e-38369
GO:0043161111EsophagusESCCproteasome-mediated ubiquitin-dependent protein catabolic process312/8552412/187233.53e-364.48e-33312
GO:0042176111EsophagusESCCregulation of protein catabolic process280/8552391/187238.65e-262.39e-23280
GO:0009896111EsophagusESCCpositive regulation of catabolic process332/8552492/187234.36e-239.22e-21332
GO:000020917EsophagusESCCprotein polyubiquitination170/8552236/187231.40e-161.09e-14170
GO:0045732111EsophagusESCCpositive regulation of protein catabolic process167/8552231/187231.47e-161.14e-14167
GO:001605517EsophagusESCCWnt signaling pathway268/8552444/187232.32e-106.58e-09268
GO:019873817EsophagusESCCcell-cell signaling by wnt269/8552446/187232.41e-106.79e-09269
GO:00715599EsophagusESCCresponse to transforming growth factor beta157/8552256/187232.95e-074.23e-06157
GO:003011117EsophagusESCCregulation of Wnt signaling pathway194/8552328/187235.39e-077.14e-06194
GO:006007016EsophagusESCCcanonical Wnt signaling pathway180/8552303/187239.15e-071.17e-05180
GO:006082817EsophagusESCCregulation of canonical Wnt signaling pathway153/8552253/187231.38e-061.67e-05153
GO:00715609EsophagusESCCcellular response to transforming growth factor beta stimulus151/8552250/187231.78e-062.10e-05151
GO:00071799EsophagusESCCtransforming growth factor beta receptor signaling pathway121/8552198/187238.26e-068.03e-05121
GO:00017387EsophagusESCCmorphogenesis of a polarized epithelium63/855294/187232.34e-052.00e-0463
GO:009026316EsophagusESCCpositive regulation of canonical Wnt signaling pathway69/8552106/187234.22e-053.39e-0469
GO:003017716EsophagusESCCpositive regulation of Wnt signaling pathway87/8552140/187236.18e-054.73e-0487
GO:000717810EsophagusESCCtransmembrane receptor protein serine/threonine kinase signaling pathway195/8552355/187232.58e-041.58e-03195
GO:00600714EsophagusESCCWnt signaling pathway, planar cell polarity pathway36/855252/187235.05e-042.79e-0336
GO:000166720EsophagusESCCameboidal-type cell migration250/8552475/187231.22e-035.97e-03250
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0412027EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
hsa04144210EsophagusESCCEndocytosis186/4205251/84659.74e-164.66e-142.39e-14186
hsa0452030EsophagusESCCAdherens junction69/420593/84651.08e-066.83e-063.50e-0669
hsa043507EsophagusESCCTGF-beta signaling pathway69/4205108/84651.92e-035.54e-032.84e-0369
hsa0412036EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
hsa0414437EsophagusESCCEndocytosis186/4205251/84659.74e-164.66e-142.39e-14186
hsa04520114EsophagusESCCAdherens junction69/420593/84651.08e-066.83e-063.50e-0669
hsa0435014EsophagusESCCTGF-beta signaling pathway69/4205108/84651.92e-035.54e-032.84e-0369
hsa0452016LungIACAdherens junction37/105393/84651.99e-112.16e-091.43e-0937
hsa0412012LungIACUbiquitin mediated proteolysis40/1053142/84653.24e-071.76e-051.17e-0540
hsa0414414LungIACEndocytosis51/1053251/84652.25e-042.54e-031.68e-0351
hsa0452017LungIACAdherens junction37/105393/84651.99e-112.16e-091.43e-0937
hsa0412013LungIACUbiquitin mediated proteolysis40/1053142/84653.24e-071.76e-051.17e-0540
hsa0414415LungIACEndocytosis51/1053251/84652.25e-042.54e-031.68e-0351
hsa0452023LungAISAdherens junction34/96193/84651.59e-101.29e-088.26e-0934
hsa0412022LungAISUbiquitin mediated proteolysis41/961142/84658.01e-094.33e-072.77e-0741
hsa0414423LungAISEndocytosis52/961251/84659.74e-063.04e-041.95e-0452
hsa04340LungAISHedgehog signaling pathway14/96156/84653.21e-031.82e-021.17e-0214
hsa0452033LungAISAdherens junction34/96193/84651.59e-101.29e-088.26e-0934
hsa0412032LungAISUbiquitin mediated proteolysis41/961142/84658.01e-094.33e-072.77e-0741
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SMURF2SNVMissense_Mutationnovelc.1678N>Gp.Ile560Valp.I560VQ9HAU4protein_codingtolerated(1)benign(0)TCGA-A7-A56D-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
SMURF2SNVMissense_Mutationnovelc.1819G>Ap.Glu607Lysp.E607KQ9HAU4protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AC-A2QI-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycytoxanCR
SMURF2SNVMissense_Mutationnovelc.1108N>Gp.Arg370Glyp.R370GQ9HAU4protein_codingdeleterious(0)probably_damaging(0.998)TCGA-E2-A574-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
SMURF2SNVMissense_Mutationnovelc.2110N>Ap.Asp704Asnp.D704NQ9HAU4protein_codingtolerated(0.14)benign(0.372)TCGA-EW-A1PC-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
SMURF2insertionIn_Frame_Insnovelc.2013_2014insACTACTACTATTTTTATAAAAGGTAATCTATTCAAATTTCTTCACAGAp.Leu671_Leu672insThrThrThrIlePheIleLysGlyAsnLeuPheLysPheLeuHisArgp.L671_L672insTTTIFIKGNLFKFLHRQ9HAU4protein_codingTCGA-A8-A07J-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapy5-fluorouracilCR
SMURF2insertionNonsense_Mutationnovelc.832_833insATTTAACCTCATAAATGCATTCAATGTTCTGTTATGTp.Thr278AsnfsTer5p.T278Nfs*5Q9HAU4protein_codingTCGA-AN-A0FX-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SMURF2insertionFrame_Shift_Insnovelc.1999_2000insATCCTCACACTTCCCAGATGCATAAAGTGAAGTTGTATp.Arg667HisfsTer22p.R667Hfs*22Q9HAU4protein_codingTCGA-AO-A0JB-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
SMURF2deletionFrame_Shift_Delc.1412_1413delNNp.Pro471ArgfsTer5p.P471Rfs*5Q9HAU4protein_codingTCGA-C8-A12M-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SMURF2SNVMissense_Mutationnovelc.1017N>Gp.Asn339Lysp.N339KQ9HAU4protein_codingtolerated(0.23)benign(0.354)TCGA-DS-A1OD-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
SMURF2SNVMissense_Mutationnovelc.821N>Ap.Thr274Asnp.T274NQ9HAU4protein_codingtolerated(0.06)probably_damaging(0.999)TCGA-EK-A2RE-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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