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Gene: SMIM8 |
Gene summary for SMIM8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SMIM8 | Gene ID | 57150 |
| Gene name | small integral membrane protein 8 | |
| Gene Alias | C6orf162 | |
| Cytomap | 6q15 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96KF7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57150 | SMIM8 | LZE4T | Human | Esophagus | ESCC | 1.48e-02 | 1.15e-01 | 0.0811 |
| 57150 | SMIM8 | LZE5T | Human | Esophagus | ESCC | 4.70e-02 | 2.43e-01 | 0.0514 |
| 57150 | SMIM8 | LZE8T | Human | Esophagus | ESCC | 4.31e-04 | 1.86e-01 | 0.067 |
| 57150 | SMIM8 | LZE24T | Human | Esophagus | ESCC | 5.63e-25 | 6.13e-01 | 0.0596 |
| 57150 | SMIM8 | LZE21T | Human | Esophagus | ESCC | 5.91e-04 | 2.63e-01 | 0.0655 |
| 57150 | SMIM8 | P2T-E | Human | Esophagus | ESCC | 1.33e-21 | 4.33e-01 | 0.1177 |
| 57150 | SMIM8 | P4T-E | Human | Esophagus | ESCC | 7.68e-19 | 4.44e-01 | 0.1323 |
| 57150 | SMIM8 | P5T-E | Human | Esophagus | ESCC | 6.77e-23 | 2.72e-01 | 0.1327 |
| 57150 | SMIM8 | P8T-E | Human | Esophagus | ESCC | 3.58e-18 | 2.88e-01 | 0.0889 |
| 57150 | SMIM8 | P9T-E | Human | Esophagus | ESCC | 1.31e-06 | 2.10e-01 | 0.1131 |
| 57150 | SMIM8 | P10T-E | Human | Esophagus | ESCC | 3.04e-14 | 3.24e-01 | 0.116 |
| 57150 | SMIM8 | P11T-E | Human | Esophagus | ESCC | 9.29e-08 | 3.65e-01 | 0.1426 |
| 57150 | SMIM8 | P12T-E | Human | Esophagus | ESCC | 1.64e-25 | 4.91e-01 | 0.1122 |
| 57150 | SMIM8 | P15T-E | Human | Esophagus | ESCC | 2.67e-15 | 3.39e-01 | 0.1149 |
| 57150 | SMIM8 | P16T-E | Human | Esophagus | ESCC | 3.07e-17 | 4.55e-01 | 0.1153 |
| 57150 | SMIM8 | P20T-E | Human | Esophagus | ESCC | 2.08e-12 | 2.88e-01 | 0.1124 |
| 57150 | SMIM8 | P21T-E | Human | Esophagus | ESCC | 3.58e-15 | 3.62e-01 | 0.1617 |
| 57150 | SMIM8 | P22T-E | Human | Esophagus | ESCC | 1.32e-11 | 2.32e-01 | 0.1236 |
| 57150 | SMIM8 | P23T-E | Human | Esophagus | ESCC | 5.56e-16 | 4.01e-01 | 0.108 |
| 57150 | SMIM8 | P24T-E | Human | Esophagus | ESCC | 1.21e-07 | 1.81e-01 | 0.1287 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SMIM8 | SNV | Missense_Mutation | c.167N>T | p.Thr56Ile | p.T56I | Q96KF7 | protein_coding | deleterious(0.01) | benign(0.259) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
| SMIM8 | SNV | Missense_Mutation | novel | c.146N>G | p.Val49Gly | p.V49G | Q96KF7 | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| SMIM8 | SNV | Missense_Mutation | novel | c.137N>G | p.Asn46Ser | p.N46S | Q96KF7 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SMIM8 | SNV | Missense_Mutation | novel | c.104G>A | p.Arg35His | p.R35H | Q96KF7 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SMIM8 | SNV | Missense_Mutation | c.36G>T | p.Lys12Asn | p.K12N | Q96KF7 | protein_coding | tolerated(0.78) | benign(0.001) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
| SMIM8 | SNV | Missense_Mutation | c.226N>T | p.Asp76Tyr | p.D76Y | Q96KF7 | protein_coding | deleterious(0) | possibly_damaging(0.598) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
| SMIM8 | SNV | Missense_Mutation | c.245N>C | p.Asp82Ala | p.D82A | Q96KF7 | protein_coding | deleterious(0) | benign(0.194) | TCGA-L9-A743-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | taxotere | CR | |
| SMIM8 | SNV | Missense_Mutation | rs140990223 | c.86N>A | p.Arg29His | p.R29H | Q96KF7 | protein_coding | tolerated(0.08) | benign(0) | TCGA-39-5037-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD |
| SMIM8 | SNV | Missense_Mutation | rs138742161 | c.103N>T | p.Arg35Cys | p.R35C | Q96KF7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SMIM8 | SNV | Missense_Mutation | c.71G>T | p.Gly24Val | p.G24V | Q96KF7 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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