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Gene: SMIM37 |
Gene summary for SMIM37 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SMIM37 | Gene ID | 205251 |
| Gene name | mitoregulin | |
| Gene Alias | LEMP | |
| Cytomap | 2q13 | |
| Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 205251 | SMIM37 | S014 | Human | Liver | HCC | 2.92e-68 | 1.73e+00 | 0.2254 |
| 205251 | SMIM37 | S015 | Human | Liver | HCC | 7.07e-56 | 2.00e+00 | 0.2375 |
| 205251 | SMIM37 | S016 | Human | Liver | HCC | 1.76e-63 | 1.85e+00 | 0.2243 |
| 205251 | SMIM37 | S027 | Human | Liver | HCC | 1.51e-23 | 1.62e+00 | 0.2446 |
| 205251 | SMIM37 | S028 | Human | Liver | HCC | 5.33e-49 | 1.77e+00 | 0.2503 |
| 205251 | SMIM37 | S029 | Human | Liver | HCC | 2.69e-38 | 1.61e+00 | 0.2581 |
| 205251 | SMIM37 | PTC01 | Human | Thyroid | PTC | 1.02e-18 | 3.61e-01 | 0.1899 |
| 205251 | SMIM37 | PTC03 | Human | Thyroid | PTC | 2.01e-10 | 4.64e-01 | 0.1784 |
| 205251 | SMIM37 | PTC04 | Human | Thyroid | PTC | 5.88e-09 | 2.42e-01 | 0.1927 |
| 205251 | SMIM37 | PTC05 | Human | Thyroid | PTC | 2.38e-23 | 8.12e-01 | 0.2065 |
| 205251 | SMIM37 | PTC06 | Human | Thyroid | PTC | 2.00e-43 | 8.87e-01 | 0.2057 |
| 205251 | SMIM37 | PTC07 | Human | Thyroid | PTC | 4.84e-63 | 1.04e+00 | 0.2044 |
| 205251 | SMIM37 | ATC11 | Human | Thyroid | ATC | 2.02e-16 | 1.15e+00 | 0.3386 |
| 205251 | SMIM37 | ATC12 | Human | Thyroid | ATC | 6.62e-35 | 6.87e-01 | 0.34 |
| 205251 | SMIM37 | ATC13 | Human | Thyroid | ATC | 2.18e-22 | 5.13e-01 | 0.34 |
| 205251 | SMIM37 | ATC2 | Human | Thyroid | ATC | 3.52e-25 | 1.57e+00 | 0.34 |
| 205251 | SMIM37 | ATC3 | Human | Thyroid | ATC | 1.38e-16 | 9.50e-01 | 0.338 |
| 205251 | SMIM37 | ATC4 | Human | Thyroid | ATC | 1.91e-44 | 9.47e-01 | 0.34 |
| 205251 | SMIM37 | ATC5 | Human | Thyroid | ATC | 6.16e-27 | 5.48e-01 | 0.34 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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