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Gene: SMIM20 |
Gene summary for SMIM20 |
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Gene information | Species | Human | Gene symbol | SMIM20 | Gene ID | 389203 |
Gene name | small integral membrane protein 20 | |
Gene Alias | C4orf52 | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q8N5G0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389203 | SMIM20 | LZE4T | Human | Esophagus | ESCC | 1.15e-02 | -1.75e-02 | 0.0811 |
389203 | SMIM20 | LZE7T | Human | Esophagus | ESCC | 2.97e-04 | 3.87e-01 | 0.0667 |
389203 | SMIM20 | LZE8T | Human | Esophagus | ESCC | 8.42e-04 | 1.37e-01 | 0.067 |
389203 | SMIM20 | LZE20T | Human | Esophagus | ESCC | 6.88e-12 | 2.88e-01 | 0.0662 |
389203 | SMIM20 | LZE22D1 | Human | Esophagus | HGIN | 2.32e-03 | 1.07e-01 | 0.0595 |
389203 | SMIM20 | LZE22T | Human | Esophagus | ESCC | 1.48e-03 | 3.17e-01 | 0.068 |
389203 | SMIM20 | LZE24T | Human | Esophagus | ESCC | 4.28e-13 | 4.18e-01 | 0.0596 |
389203 | SMIM20 | LZE6T | Human | Esophagus | ESCC | 2.30e-03 | 3.29e-01 | 0.0845 |
389203 | SMIM20 | P1T-E | Human | Esophagus | ESCC | 1.19e-04 | 2.99e-01 | 0.0875 |
389203 | SMIM20 | P2T-E | Human | Esophagus | ESCC | 6.36e-32 | 7.40e-01 | 0.1177 |
389203 | SMIM20 | P4T-E | Human | Esophagus | ESCC | 5.28e-35 | 7.66e-01 | 0.1323 |
389203 | SMIM20 | P5T-E | Human | Esophagus | ESCC | 1.52e-20 | 3.34e-01 | 0.1327 |
389203 | SMIM20 | P8T-E | Human | Esophagus | ESCC | 2.88e-19 | 5.03e-01 | 0.0889 |
389203 | SMIM20 | P9T-E | Human | Esophagus | ESCC | 6.56e-14 | 3.30e-01 | 0.1131 |
389203 | SMIM20 | P10T-E | Human | Esophagus | ESCC | 1.08e-25 | 3.93e-01 | 0.116 |
389203 | SMIM20 | P11T-E | Human | Esophagus | ESCC | 2.08e-16 | 5.78e-01 | 0.1426 |
389203 | SMIM20 | P12T-E | Human | Esophagus | ESCC | 2.26e-28 | 4.41e-01 | 0.1122 |
389203 | SMIM20 | P15T-E | Human | Esophagus | ESCC | 2.93e-19 | 3.99e-01 | 0.1149 |
389203 | SMIM20 | P16T-E | Human | Esophagus | ESCC | 9.02e-27 | 6.30e-01 | 0.1153 |
389203 | SMIM20 | P17T-E | Human | Esophagus | ESCC | 2.44e-14 | 4.85e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003310820 | Esophagus | HGIN | mitochondrial respiratory chain complex assembly | 47/2587 | 93/18723 | 3.15e-17 | 8.60e-15 | 47 |
GO:00170044 | Esophagus | HGIN | cytochrome complex assembly | 18/2587 | 36/18723 | 2.39e-07 | 1.14e-05 | 18 |
GO:00336173 | Esophagus | HGIN | mitochondrial cytochrome c oxidase assembly | 13/2587 | 22/18723 | 9.51e-07 | 3.80e-05 | 13 |
GO:00085353 | Esophagus | HGIN | respiratory chain complex IV assembly | 14/2587 | 26/18723 | 1.68e-06 | 6.29e-05 | 14 |
GO:0033108110 | Esophagus | ESCC | mitochondrial respiratory chain complex assembly | 83/8552 | 93/18723 | 9.56e-19 | 1.05e-16 | 83 |
GO:001700413 | Esophagus | ESCC | cytochrome complex assembly | 34/8552 | 36/18723 | 5.08e-10 | 1.31e-08 | 34 |
GO:000853512 | Esophagus | ESCC | respiratory chain complex IV assembly | 24/8552 | 26/18723 | 6.87e-07 | 8.99e-06 | 24 |
GO:003361712 | Esophagus | ESCC | mitochondrial cytochrome c oxidase assembly | 21/8552 | 22/18723 | 8.75e-07 | 1.13e-05 | 21 |
GO:00331087 | Liver | Cirrhotic | mitochondrial respiratory chain complex assembly | 64/4634 | 93/18723 | 3.85e-19 | 7.79e-17 | 64 |
GO:0017004 | Liver | Cirrhotic | cytochrome complex assembly | 22/4634 | 36/18723 | 3.92e-06 | 6.70e-05 | 22 |
GO:0033617 | Liver | Cirrhotic | mitochondrial cytochrome c oxidase assembly | 14/4634 | 22/18723 | 1.27e-04 | 1.25e-03 | 14 |
GO:0008535 | Liver | Cirrhotic | respiratory chain complex IV assembly | 15/4634 | 26/18723 | 3.43e-04 | 2.93e-03 | 15 |
GO:003310812 | Liver | HCC | mitochondrial respiratory chain complex assembly | 80/7958 | 93/18723 | 3.47e-18 | 4.15e-16 | 80 |
GO:00170041 | Liver | HCC | cytochrome complex assembly | 30/7958 | 36/18723 | 5.69e-07 | 9.03e-06 | 30 |
GO:00336171 | Liver | HCC | mitochondrial cytochrome c oxidase assembly | 20/7958 | 22/18723 | 3.00e-06 | 3.98e-05 | 20 |
GO:00085351 | Liver | HCC | respiratory chain complex IV assembly | 22/7958 | 26/18723 | 1.23e-05 | 1.39e-04 | 22 |
GO:003310818 | Oral cavity | OSCC | mitochondrial respiratory chain complex assembly | 75/7305 | 93/18723 | 2.17e-16 | 1.68e-14 | 75 |
GO:00170043 | Oral cavity | OSCC | cytochrome complex assembly | 31/7305 | 36/18723 | 7.28e-09 | 1.53e-07 | 31 |
GO:00336172 | Oral cavity | OSCC | mitochondrial cytochrome c oxidase assembly | 19/7305 | 22/18723 | 6.52e-06 | 7.21e-05 | 19 |
GO:00085352 | Oral cavity | OSCC | respiratory chain complex IV assembly | 21/7305 | 26/18723 | 1.66e-05 | 1.64e-04 | 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SMIM20 | insertion | Frame_Shift_Ins | novel | c.161_162insGTCTGCTGGTCCTCCACTAGAGCACCCTCAACGAATAATCCTG | p.Pro55SerfsTer22 | p.P55Sfs*22 | Q8N5G0 | protein_coding | TCGA-A2-A0EO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
SMIM20 | SNV | Missense_Mutation | c.184N>C | p.Asp62His | p.D62H | Q8N5G0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SMIM20 | SNV | Missense_Mutation | c.133N>A | p.Ala45Thr | p.A45T | Q8N5G0 | protein_coding | tolerated(0.16) | probably_damaging(0.998) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SMIM20 | deletion | Frame_Shift_Del | novel | c.193delN | p.Gly65AlafsTer12 | p.G65Afs*12 | Q8N5G0 | protein_coding | TCGA-DD-AAD0-01 | Liver | liver hepatocellular carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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