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Gene: SMEK2 |
Gene summary for SMEK2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SMEK2 | Gene ID | 57223 |
| Gene name | protein phosphatase 4 regulatory subunit 3B | |
| Gene Alias | FLFL2 | |
| Cytomap | 2p16.1 | |
| Gene Type | protein-coding | GO ID | GO:0005975 | UniProtAcc | Q5MIZ7 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 57223 | SMEK2 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 1.14e-06 | 6.73e-01 | 0.1557 |
| 57223 | SMEK2 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 1.29e-04 | 5.47e-01 | 0.159 |
| 57223 | SMEK2 | GSM5353217_PA_PB1A_Pool_2_S107_L004 | Human | Prostate | Tumor | 1.33e-04 | 6.14e-01 | 0.156 |
| 57223 | SMEK2 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 6.49e-08 | 7.17e-01 | 0.1479 |
| 57223 | SMEK2 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 7.14e-06 | 5.63e-01 | 0.1531 |
| 57223 | SMEK2 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 4.28e-30 | 8.57e-01 | 0.1633 |
| 57223 | SMEK2 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 5.61e-19 | 5.76e-01 | 0.1608 |
| 57223 | SMEK2 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 8.77e-19 | 6.50e-01 | 0.1604 |
| 57223 | SMEK2 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 1.39e-13 | 4.59e-01 | 0.1621 |
| 57223 | SMEK2 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 1.83e-09 | 6.21e-01 | 0.1619 |
| 57223 | SMEK2 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 3.79e-09 | 7.03e-01 | 0.159 |
| 57223 | SMEK2 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 9.38e-11 | 5.08e-01 | 0.1602 |
| 57223 | SMEK2 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.14e-06 | 5.65e-01 | 0.1622 |
| 57223 | SMEK2 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 7.66e-11 | 4.34e-01 | 0.1575 |
| 57223 | SMEK2 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 7.66e-05 | 3.06e-01 | 0.1569 |
| 57223 | SMEK2 | P1_S1_AK | Human | Skin | AK | 4.01e-03 | -1.17e-01 | -0.3399 |
| 57223 | SMEK2 | P2_S3_AK | Human | Skin | AK | 4.01e-03 | -1.17e-01 | -0.3287 |
| 57223 | SMEK2 | P2_S4_SCCIS | Human | Skin | SCCIS | 8.47e-03 | -1.17e-01 | -0.3043 |
| 57223 | SMEK2 | P3_S6_AK | Human | Skin | AK | 1.90e-03 | -1.17e-01 | -0.3256 |
| 57223 | SMEK2 | P5_S10_cSCC | Human | Skin | cSCC | 1.90e-03 | -1.17e-01 | -0.299 |
| Page: 1 2 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0492214 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
| hsa0492215 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
| hsa0492221 | Liver | Cirrhotic | Glucagon signaling pathway | 43/2530 | 107/8465 | 1.42e-02 | 4.35e-02 | 2.68e-02 | 43 |
| hsa0492231 | Liver | Cirrhotic | Glucagon signaling pathway | 43/2530 | 107/8465 | 1.42e-02 | 4.35e-02 | 2.68e-02 | 43 |
| hsa0492241 | Liver | HCC | Glucagon signaling pathway | 64/4020 | 107/8465 | 6.70e-03 | 1.87e-02 | 1.04e-02 | 64 |
| hsa0492251 | Liver | HCC | Glucagon signaling pathway | 64/4020 | 107/8465 | 6.70e-03 | 1.87e-02 | 1.04e-02 | 64 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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