|
Gene: SMEK1 |
Gene summary for SMEK1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SMEK1 | Gene ID | 55671 |
Gene name | protein phosphatase 4 regulatory subunit 3A | |
Gene Alias | FLFL1 | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R6M2 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55671 | SMEK1 | GSM5353215_PA_AUG_PB_1B_S2 | Human | Prostate | Tumor | 4.40e-03 | 3.98e-01 | 0.1557 |
55671 | SMEK1 | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 9.10e-10 | 8.21e-01 | 0.159 |
55671 | SMEK1 | GSM5353217_PA_PB1A_Pool_2_S107_L004 | Human | Prostate | Tumor | 3.83e-03 | 5.21e-01 | 0.156 |
55671 | SMEK1 | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 7.60e-04 | 5.40e-01 | 0.1479 |
55671 | SMEK1 | GSM5353220_PA_PB1B_Pool_3_S51_L002 | Human | Prostate | Tumor | 3.78e-07 | 6.91e-01 | 0.1531 |
55671 | SMEK1 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 5.34e-33 | 8.90e-01 | 0.1633 |
55671 | SMEK1 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 2.29e-20 | 6.18e-01 | 0.1608 |
55671 | SMEK1 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 7.31e-18 | 7.18e-01 | 0.1604 |
55671 | SMEK1 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 2.07e-22 | 6.38e-01 | 0.1621 |
55671 | SMEK1 | GSM5353225_PA_PR5196-1_Pool_1_2_3_S53_L002 | Human | Prostate | Tumor | 1.50e-10 | 6.96e-01 | 0.1619 |
55671 | SMEK1 | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 1.14e-06 | 5.27e-01 | 0.159 |
55671 | SMEK1 | GSM5353227_PA_PR5199-193K_Pool_1_2_3_S55_L002 | Human | Prostate | Tumor | 7.60e-18 | 6.78e-01 | 0.1602 |
55671 | SMEK1 | GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004 | Human | Prostate | Tumor | 2.86e-04 | 8.43e-01 | 0.1537 |
55671 | SMEK1 | GSM5353236_PA_PR5251_T1_S7_L001 | Human | Prostate | Tumor | 5.58e-07 | 5.39e-01 | 0.1608 |
55671 | SMEK1 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 3.79e-09 | 6.03e-01 | 0.1622 |
55671 | SMEK1 | GSM5353240_PA_PR5254_T1_S15_L001 | Human | Prostate | Tumor | 3.09e-16 | 5.32e-01 | 0.1575 |
55671 | SMEK1 | GSM5353243_PA_PR5261_T1_S23_L002 | Human | Prostate | Tumor | 5.42e-11 | 4.90e-01 | 0.1545 |
55671 | SMEK1 | GSM5353244_PA_PR5261_T2_S24_L002 | Human | Prostate | Tumor | 2.82e-09 | 4.89e-01 | 0.1569 |
55671 | SMEK1 | GSM5353247_PA_PR5269_3_S27_L002 | Human | Prostate | Tumor | 3.83e-03 | 7.35e-01 | 0.1532 |
55671 | SMEK1 | P1_S1_AK | Human | Skin | AK | 1.90e-03 | -1.20e-01 | -0.3399 |
Page: 1 2 |
Transcriptomic changes along malignancy continuum. |
Tissue | Expression Dynamics | Abbreviation |
Prostate | BPH: Benign Prostatic Hyperplasia | |
Skin | AK: Actinic keratosis | |
cSCC: Cutaneous squamous cell carcinoma | ||
SCCIS:squamous cell carcinoma in situ |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0492214 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
hsa0492215 | Esophagus | ESCC | Glucagon signaling pathway | 64/4205 | 107/8465 | 2.18e-02 | 4.80e-02 | 2.46e-02 | 64 |
hsa0492210 | Liver | NAFLD | Glucagon signaling pathway | 24/1043 | 107/8465 | 2.33e-03 | 2.46e-02 | 1.99e-02 | 24 |
hsa0492211 | Liver | NAFLD | Glucagon signaling pathway | 24/1043 | 107/8465 | 2.33e-03 | 2.46e-02 | 1.99e-02 | 24 |
hsa0492221 | Liver | Cirrhotic | Glucagon signaling pathway | 43/2530 | 107/8465 | 1.42e-02 | 4.35e-02 | 2.68e-02 | 43 |
hsa0492231 | Liver | Cirrhotic | Glucagon signaling pathway | 43/2530 | 107/8465 | 1.42e-02 | 4.35e-02 | 2.68e-02 | 43 |
hsa0492241 | Liver | HCC | Glucagon signaling pathway | 64/4020 | 107/8465 | 6.70e-03 | 1.87e-02 | 1.04e-02 | 64 |
hsa0492251 | Liver | HCC | Glucagon signaling pathway | 64/4020 | 107/8465 | 6.70e-03 | 1.87e-02 | 1.04e-02 | 64 |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |