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Gene: SLURP2 |
Gene summary for SLURP2 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SLURP2 | Gene ID | 432355 |
Gene name | secreted LY6/PLAUR domain containing 2 | |
Gene Alias | SLURP-2 | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0007154 | UniProtAcc | P0DP57 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
432355 | SLURP2 | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 1.81e-04 | 1.46e-01 | 0.0208 |
432355 | SLURP2 | sample3 | Human | Cervix | CC | 5.79e-157 | 1.95e+00 | 0.1387 |
432355 | SLURP2 | H2 | Human | Cervix | HSIL_HPV | 6.70e-14 | 3.67e-01 | 0.0632 |
432355 | SLURP2 | L1 | Human | Cervix | CC | 4.08e-11 | 4.65e-01 | 0.0802 |
432355 | SLURP2 | T3 | Human | Cervix | CC | 3.82e-154 | 1.98e+00 | 0.1389 |
432355 | SLURP2 | AEH-subject1 | Human | Endometrium | AEH | 8.53e-06 | 2.73e-01 | -0.3059 |
432355 | SLURP2 | AEH-subject2 | Human | Endometrium | AEH | 2.17e-18 | 5.66e-01 | -0.2525 |
432355 | SLURP2 | EEC-subject2 | Human | Endometrium | EEC | 1.73e-27 | 6.42e-01 | -0.2607 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:1905144 | Cervix | CC | response to acetylcholine | 9/2311 | 31/18723 | 1.04e-02 | 4.97e-02 | 9 |
GO:1905145 | Cervix | CC | cellular response to acetylcholine | 9/2311 | 31/18723 | 1.04e-02 | 4.97e-02 | 9 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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