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Gene: SLC7A10 |
Gene summary for SLC7A10 |
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Gene information | Species | Human | Gene symbol | SLC7A10 | Gene ID | 56301 |
Gene name | solute carrier family 7 member 10 | |
Gene Alias | ASC1 | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | Q9NS82 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56301 | SLC7A10 | ATC13 | Human | Thyroid | ATC | 1.12e-33 | 5.79e-01 | 0.34 |
56301 | SLC7A10 | ATC5 | Human | Thyroid | ATC | 2.56e-35 | 6.12e-01 | 0.34 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00323292 | Thyroid | ATC | serine transport | 8/6293 | 11/18723 | 9.31e-03 | 3.44e-02 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC7A10 | SNV | Missense_Mutation | novel | c.590N>A | p.Ala197Asp | p.A197D | Q9NS82 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1FD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SLC7A10 | SNV | Missense_Mutation | novel | c.391T>C | p.Tyr131His | p.Y131H | Q9NS82 | protein_coding | tolerated(0.5) | probably_damaging(0.994) | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLC7A10 | SNV | Missense_Mutation | rs778717789 | c.1201N>A | p.Val401Ile | p.V401I | Q9NS82 | protein_coding | tolerated(0.14) | benign(0.202) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD |
SLC7A10 | SNV | Missense_Mutation | rs200120655 | c.484N>T | p.Arg162Trp | p.R162W | Q9NS82 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-3664-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A10 | SNV | Missense_Mutation | rs146695125 | c.842N>T | p.Thr281Met | p.T281M | Q9NS82 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SLC7A10 | SNV | Missense_Mutation | novel | c.1564C>A | p.Pro522Thr | p.P522T | Q9NS82 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SLC7A10 | SNV | Missense_Mutation | c.974N>T | p.Ser325Leu | p.S325L | Q9NS82 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC7A10 | SNV | Missense_Mutation | novel | c.1517N>A | p.Gly506Asp | p.G506D | Q9NS82 | protein_coding | tolerated(0.37) | benign(0.021) | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
SLC7A10 | SNV | Missense_Mutation | rs147450851 | c.554N>A | p.Arg185His | p.R185H | Q9NS82 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
SLC7A10 | deletion | Frame_Shift_Del | c.1092delN | p.Ile365SerfsTer58 | p.I365Sfs*58 | Q9NS82 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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