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Gene: SLC6A14 |
Gene summary for SLC6A14 |
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Gene information | Species | Human | Gene symbol | SLC6A14 | Gene ID | 11254 |
Gene name | solute carrier family 6 member 14 | |
Gene Alias | BMIQ11 | |
Cytomap | Xq23 | |
Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | B2R8J1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11254 | SLC6A14 | P8T-E | Human | Esophagus | ESCC | 1.42e-32 | 1.43e+00 | 0.0889 |
11254 | SLC6A14 | P20T-E | Human | Esophagus | ESCC | 7.60e-05 | -4.86e-02 | 0.1124 |
11254 | SLC6A14 | P36T-E | Human | Esophagus | ESCC | 1.14e-15 | 1.37e+00 | 0.1187 |
11254 | SLC6A14 | P47T-E | Human | Esophagus | ESCC | 1.00e-05 | -4.04e-02 | 0.1067 |
11254 | SLC6A14 | P57T-E | Human | Esophagus | ESCC | 1.94e-04 | 2.94e-01 | 0.0926 |
11254 | SLC6A14 | P61T-E | Human | Esophagus | ESCC | 4.28e-05 | 3.42e-01 | 0.099 |
11254 | SLC6A14 | P75T-E | Human | Esophagus | ESCC | 9.96e-23 | 1.36e+00 | 0.1125 |
11254 | SLC6A14 | P76T-E | Human | Esophagus | ESCC | 1.30e-23 | 8.03e-01 | 0.1207 |
11254 | SLC6A14 | P82T-E | Human | Esophagus | ESCC | 9.85e-06 | 1.44e+00 | 0.1072 |
11254 | SLC6A14 | P84T-E | Human | Esophagus | ESCC | 1.04e-04 | 1.35e-01 | 0.0933 |
11254 | SLC6A14 | C21 | Human | Oral cavity | OSCC | 4.50e-04 | 1.29e+00 | 0.2678 |
11254 | SLC6A14 | SYSMH6 | Human | Oral cavity | OSCC | 5.66e-07 | 3.58e-01 | 0.1275 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:000963618 | Oral cavity | OSCC | response to toxic substance | 137/7305 | 262/18723 | 7.94e-06 | 8.52e-05 | 137 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC6A14 | SNV | Missense_Mutation | c.390C>G | p.Ile130Met | p.I130M | Q9UN76 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A7-A6VV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | |
SLC6A14 | SNV | Missense_Mutation | c.1192N>T | p.Ala398Ser | p.A398S | Q9UN76 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | |
SLC6A14 | SNV | Missense_Mutation | novel | c.1329N>A | p.Met443Ile | p.M443I | Q9UN76 | protein_coding | tolerated(0.2) | benign(0.372) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC6A14 | SNV | Missense_Mutation | rs146124970 | c.1337N>C | p.Met446Thr | p.M446T | Q9UN76 | protein_coding | tolerated(0.24) | benign(0.143) | TCGA-D8-A1XB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC6A14 | SNV | Missense_Mutation | novel | c.1060N>C | p.Asn354His | p.N354H | Q9UN76 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC6A14 | SNV | Missense_Mutation | novel | c.1294N>C | p.Thr432Pro | p.T432P | Q9UN76 | protein_coding | deleterious(0.01) | possibly_damaging(0.88) | TCGA-C5-A8ZZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | SD |
SLC6A14 | SNV | Missense_Mutation | rs782036917 | c.1802N>C | p.Arg601Thr | p.R601T | Q9UN76 | protein_coding | tolerated(0.31) | benign(0) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SLC6A14 | SNV | Missense_Mutation | c.1017N>G | p.Phe339Leu | p.F339L | Q9UN76 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
SLC6A14 | deletion | Frame_Shift_Del | novel | c.121delN | p.Lys42AsnfsTer8 | p.K42Nfs*8 | Q9UN76 | protein_coding | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC6A14 | SNV | Missense_Mutation | c.896N>A | p.Ala299Asp | p.A299D | Q9UN76 | protein_coding | deleterious(0.01) | benign(0.079) | TCGA-AA-3819-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
11254 | SLC6A14 | EXTERNAL SIDE OF PLASMA MEMBRANE, TRANSPORTER, DRUGGABLE GENOME | inhibitor | 178101406 |
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