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Gene: SLC4A8 |
Gene summary for SLC4A8 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SLC4A8 | Gene ID | 9498 |
| Gene name | solute carrier family 4 member 8 | |
| Gene Alias | NBC3 | |
| Cytomap | 12q13.13 | |
| Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q2Y0W8 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 9498 | SLC4A8 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.65e-02 | 1.62e-01 | -0.059 |
| 9498 | SLC4A8 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.78e-04 | 2.23e-01 | 0.096 |
| 9498 | SLC4A8 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.65e-04 | 3.04e-01 | 0.0338 |
| 9498 | SLC4A8 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.11e-08 | 3.41e-01 | 0.0674 |
| 9498 | SLC4A8 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.00e-04 | 3.00e-01 | 0.0588 |
| 9498 | SLC4A8 | F007 | Human | Colorectum | FAP | 4.51e-07 | 5.12e-01 | 0.1176 |
| 9498 | SLC4A8 | A002-C-010 | Human | Colorectum | FAP | 4.44e-09 | 4.20e-01 | 0.242 |
| 9498 | SLC4A8 | A001-C-207 | Human | Colorectum | FAP | 2.58e-02 | 3.08e-01 | 0.1278 |
| 9498 | SLC4A8 | A002-C-203 | Human | Colorectum | FAP | 3.86e-02 | 3.25e-01 | 0.2786 |
| 9498 | SLC4A8 | A002-C-021 | Human | Colorectum | FAP | 1.94e-18 | 5.18e-01 | 0.1171 |
| 9498 | SLC4A8 | A002-C-205 | Human | Colorectum | FAP | 2.94e-03 | 3.36e-01 | -0.1236 |
| 9498 | SLC4A8 | A001-C-104 | Human | Colorectum | FAP | 7.19e-08 | 3.98e-01 | 0.0184 |
| 9498 | SLC4A8 | CRC-1-8810 | Human | Colorectum | CRC | 2.23e-02 | 2.68e-01 | 0.6257 |
| 9498 | SLC4A8 | HCC1 | Human | Liver | HCC | 1.04e-21 | 2.23e+00 | 0.5336 |
| 9498 | SLC4A8 | HCC2 | Human | Liver | HCC | 6.24e-31 | 2.36e+00 | 0.5341 |
| 9498 | SLC4A8 | HCC5 | Human | Liver | HCC | 1.28e-34 | 2.01e+00 | 0.4932 |
| 9498 | SLC4A8 | S015 | Human | Liver | HCC | 4.25e-06 | 3.50e-01 | 0.2375 |
| 9498 | SLC4A8 | S016 | Human | Liver | HCC | 1.19e-03 | 2.23e-01 | 0.2243 |
| 9498 | SLC4A8 | HTA12-23-1 | Human | Pancreas | PDAC | 1.37e-09 | 8.09e-01 | 0.3405 |
| 9498 | SLC4A8 | HTA12-25-1 | Human | Pancreas | PDAC | 3.79e-04 | 4.44e-01 | 0.313 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0045921 | Colorectum | AD | positive regulation of exocytosis | 33/3918 | 86/18723 | 1.58e-04 | 2.20e-03 | 33 |
| GO:0051047 | Colorectum | AD | positive regulation of secretion | 90/3918 | 310/18723 | 4.11e-04 | 4.66e-03 | 90 |
| GO:0030004 | Colorectum | AD | cellular monovalent inorganic cation homeostasis | 36/3918 | 103/18723 | 6.80e-04 | 6.95e-03 | 36 |
| GO:1903532 | Colorectum | AD | positive regulation of secretion by cell | 82/3918 | 282/18723 | 6.85e-04 | 7.00e-03 | 82 |
| GO:0030641 | Colorectum | AD | regulation of cellular pH | 29/3918 | 81/18723 | 1.42e-03 | 1.22e-02 | 29 |
| GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
| GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
| GO:0051453 | Colorectum | AD | regulation of intracellular pH | 26/3918 | 75/18723 | 4.04e-03 | 2.82e-02 | 26 |
| GO:0006885 | Colorectum | AD | regulation of pH | 30/3918 | 91/18723 | 4.95e-03 | 3.32e-02 | 30 |
| GO:0055067 | Colorectum | AD | monovalent inorganic cation homeostasis | 45/3918 | 151/18723 | 6.19e-03 | 3.88e-02 | 45 |
| GO:0099003 | Colorectum | AD | vesicle-mediated transport in synapse | 57/3918 | 200/18723 | 6.53e-03 | 4.06e-02 | 57 |
| GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
| GO:00990032 | Colorectum | FAP | vesicle-mediated transport in synapse | 51/2622 | 200/18723 | 1.09e-05 | 3.08e-04 | 51 |
| GO:00995041 | Colorectum | FAP | synaptic vesicle cycle | 45/2622 | 181/18723 | 6.73e-05 | 1.28e-03 | 45 |
| GO:0035725 | Colorectum | FAP | sodium ion transmembrane transport | 44/2622 | 178/18723 | 9.31e-05 | 1.60e-03 | 44 |
| GO:0023061 | Colorectum | FAP | signal release | 94/2622 | 463/18723 | 1.06e-04 | 1.76e-03 | 94 |
| GO:00510473 | Colorectum | FAP | positive regulation of secretion | 67/2622 | 310/18723 | 1.59e-04 | 2.43e-03 | 67 |
| GO:19035322 | Colorectum | FAP | positive regulation of secretion by cell | 62/2622 | 282/18723 | 1.67e-04 | 2.52e-03 | 62 |
| GO:01501041 | Colorectum | FAP | transport across blood-brain barrier | 25/2622 | 87/18723 | 2.63e-04 | 3.59e-03 | 25 |
| GO:00102321 | Colorectum | FAP | vascular transport | 25/2622 | 88/18723 | 3.19e-04 | 4.12e-03 | 25 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SLC4A8 | SNV | Missense_Mutation | novel | c.2866N>C | p.Thr956Pro | p.T956P | Q2Y0W8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A7-A26G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
| SLC4A8 | SNV | Missense_Mutation | novel | c.1780G>A | p.Glu594Lys | p.E594K | Q2Y0W8 | protein_coding | deleterious(0.02) | benign(0.167) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| SLC4A8 | SNV | Missense_Mutation | c.681N>T | p.Lys227Asn | p.K227N | Q2Y0W8 | protein_coding | deleterious(0.03) | benign(0.168) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SLC4A8 | SNV | Missense_Mutation | c.1331N>T | p.Glu444Val | p.E444V | Q2Y0W8 | protein_coding | deleterious(0) | probably_damaging(0.954) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| SLC4A8 | SNV | Missense_Mutation | c.796N>G | p.Thr266Ala | p.T266A | Q2Y0W8 | protein_coding | tolerated(0.72) | benign(0.003) | TCGA-E2-A1IG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| SLC4A8 | SNV | Missense_Mutation | novel | c.2866N>C | p.Thr956Pro | p.T956P | Q2Y0W8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-E9-A22A-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
| SLC4A8 | insertion | Nonsense_Mutation | novel | c.1518_1519insCATTTATAGTTATACCATCCATATGAGCCTCAGATCTTTCCC | p.Gly506_Arg507insHisLeuTerLeuTyrHisProTyrGluProGlnIlePhePro | p.G506_R507insHL*LYHPYEPQIFP | Q2Y0W8 | protein_coding | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD | ||
| SLC4A8 | insertion | Nonsense_Mutation | novel | c.1203_1204insTGTGAATGTCTTGACTAGTCTGTACCAAAACAACCA | p.Trp401_Asp402insCysGluCysLeuAspTerSerValProLysGlnPro | p.W401_D402insCECLD*SVPKQP | Q2Y0W8 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
| SLC4A8 | insertion | Nonsense_Mutation | novel | c.1610_1611insCCTTAAGTTGGTTTTGCACATTTCCTCCTAACAGCTCAGAAT | p.Ser537_Thr538insLeuLysLeuValLeuHisIleSerSerTerGlnLeuArgIle | p.S537_T538insLKLVLHISS*QLRI | Q2Y0W8 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| SLC4A8 | insertion | Frame_Shift_Ins | novel | c.1611_1612insC | p.Thr538HisfsTer8 | p.T538Hfs*8 | Q2Y0W8 | protein_coding | TCGA-B6-A0I5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 9498 | SLC4A8 | TRANSPORTER, DRUGGABLE GENOME, EXTERNAL SIDE OF PLASMA MEMBRANE | ethanol | ALCOHOL | 32451486 |
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