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Gene: SLC48A1 |
Gene summary for SLC48A1 |
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Gene information | Species | Human | Gene symbol | SLC48A1 | Gene ID | 55652 |
Gene name | solute carrier family 48 member 1 | |
Gene Alias | HRG-1 | |
Cytomap | 12q13.11 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q6P1K1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55652 | SLC48A1 | LZE4T | Human | Esophagus | ESCC | 2.75e-05 | 1.55e-01 | 0.0811 |
55652 | SLC48A1 | LZE20T | Human | Esophagus | ESCC | 8.87e-10 | 4.41e-01 | 0.0662 |
55652 | SLC48A1 | LZE24T | Human | Esophagus | ESCC | 2.51e-07 | 1.10e-01 | 0.0596 |
55652 | SLC48A1 | P1T-E | Human | Esophagus | ESCC | 2.69e-04 | 1.73e-01 | 0.0875 |
55652 | SLC48A1 | P2T-E | Human | Esophagus | ESCC | 2.38e-20 | 3.49e-01 | 0.1177 |
55652 | SLC48A1 | P4T-E | Human | Esophagus | ESCC | 8.75e-07 | 1.15e-01 | 0.1323 |
55652 | SLC48A1 | P5T-E | Human | Esophagus | ESCC | 5.97e-17 | 3.46e-01 | 0.1327 |
55652 | SLC48A1 | P8T-E | Human | Esophagus | ESCC | 1.22e-12 | 1.52e-01 | 0.0889 |
55652 | SLC48A1 | P9T-E | Human | Esophagus | ESCC | 1.14e-02 | 8.13e-02 | 0.1131 |
55652 | SLC48A1 | P10T-E | Human | Esophagus | ESCC | 6.77e-11 | 1.97e-01 | 0.116 |
55652 | SLC48A1 | P11T-E | Human | Esophagus | ESCC | 2.52e-03 | 2.68e-01 | 0.1426 |
55652 | SLC48A1 | P12T-E | Human | Esophagus | ESCC | 8.10e-16 | 1.66e-01 | 0.1122 |
55652 | SLC48A1 | P15T-E | Human | Esophagus | ESCC | 1.88e-21 | 3.66e-01 | 0.1149 |
55652 | SLC48A1 | P16T-E | Human | Esophagus | ESCC | 1.23e-05 | 7.44e-02 | 0.1153 |
55652 | SLC48A1 | P17T-E | Human | Esophagus | ESCC | 1.27e-14 | 3.75e-01 | 0.1278 |
55652 | SLC48A1 | P20T-E | Human | Esophagus | ESCC | 1.87e-07 | 9.75e-02 | 0.1124 |
55652 | SLC48A1 | P21T-E | Human | Esophagus | ESCC | 1.01e-21 | 4.45e-01 | 0.1617 |
55652 | SLC48A1 | P22T-E | Human | Esophagus | ESCC | 9.86e-13 | 2.20e-01 | 0.1236 |
55652 | SLC48A1 | P23T-E | Human | Esophagus | ESCC | 4.21e-09 | 1.32e-01 | 0.108 |
55652 | SLC48A1 | P24T-E | Human | Esophagus | ESCC | 6.72e-09 | 9.81e-02 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00000411 | Liver | HCC | transition metal ion transport | 59/7958 | 105/18723 | 3.18e-03 | 1.47e-02 | 59 |
GO:0015886 | Liver | HCC | heme transport | 9/7958 | 11/18723 | 9.51e-03 | 3.60e-02 | 9 |
GO:00068261 | Liver | HCC | iron ion transport | 34/7958 | 58/18723 | 9.66e-03 | 3.63e-02 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC48A1 | SNV | Missense_Mutation | novel | c.230T>C | p.Val77Ala | p.V77A | Q6P1K1 | protein_coding | tolerated(0.33) | benign(0.018) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC48A1 | SNV | Missense_Mutation | c.431N>T | p.Ser144Ile | p.S144I | Q6P1K1 | protein_coding | deleterious(0.01) | possibly_damaging(0.764) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC48A1 | SNV | Missense_Mutation | rs772579767 | c.296G>A | p.Arg99Gln | p.R99Q | Q6P1K1 | protein_coding | tolerated(0.97) | benign(0.001) | TCGA-D1-A161-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC48A1 | SNV | Missense_Mutation | novel | c.366N>T | p.Trp122Cys | p.W122C | Q6P1K1 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-SJ-A6ZI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC48A1 | SNV | Missense_Mutation | novel | c.401N>T | p.Arg134Leu | p.R134L | Q6P1K1 | protein_coding | tolerated(0.05) | possibly_damaging(0.831) | TCGA-05-4396-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
SLC48A1 | SNV | Missense_Mutation | rs747390223 | c.400N>T | p.Arg134Trp | p.R134W | Q6P1K1 | protein_coding | deleterious(0) | benign(0.072) | TCGA-CG-4438-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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