![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC43A3 |
Gene summary for SLC43A3 |
![]() |
Gene information | Species | Human | Gene symbol | SLC43A3 | Gene ID | 29015 |
Gene name | solute carrier family 43 member 3 | |
Gene Alias | EEG1 | |
Cytomap | 11q12.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R4Y2 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
29015 | SLC43A3 | LZE22T | Human | Esophagus | ESCC | 2.49e-02 | 1.28e-01 | 0.068 |
29015 | SLC43A3 | P2T-E | Human | Esophagus | ESCC | 3.57e-22 | 2.28e-01 | 0.1177 |
29015 | SLC43A3 | P4T-E | Human | Esophagus | ESCC | 1.60e-10 | 3.19e-01 | 0.1323 |
29015 | SLC43A3 | P8T-E | Human | Esophagus | ESCC | 5.45e-04 | 7.20e-02 | 0.0889 |
29015 | SLC43A3 | P9T-E | Human | Esophagus | ESCC | 1.27e-04 | -3.68e-02 | 0.1131 |
29015 | SLC43A3 | P10T-E | Human | Esophagus | ESCC | 2.42e-09 | 1.52e-01 | 0.116 |
29015 | SLC43A3 | P11T-E | Human | Esophagus | ESCC | 2.69e-06 | 3.14e-01 | 0.1426 |
29015 | SLC43A3 | P12T-E | Human | Esophagus | ESCC | 1.13e-03 | -7.27e-02 | 0.1122 |
29015 | SLC43A3 | P16T-E | Human | Esophagus | ESCC | 6.30e-05 | 9.56e-02 | 0.1153 |
29015 | SLC43A3 | P17T-E | Human | Esophagus | ESCC | 3.25e-07 | 5.96e-01 | 0.1278 |
29015 | SLC43A3 | P19T-E | Human | Esophagus | ESCC | 2.54e-03 | 2.83e-01 | 0.1662 |
29015 | SLC43A3 | P20T-E | Human | Esophagus | ESCC | 2.33e-13 | 1.56e-01 | 0.1124 |
29015 | SLC43A3 | P21T-E | Human | Esophagus | ESCC | 1.70e-21 | 5.70e-01 | 0.1617 |
29015 | SLC43A3 | P23T-E | Human | Esophagus | ESCC | 4.30e-02 | -1.80e-02 | 0.108 |
29015 | SLC43A3 | P24T-E | Human | Esophagus | ESCC | 1.83e-09 | 1.03e-01 | 0.1287 |
29015 | SLC43A3 | P27T-E | Human | Esophagus | ESCC | 3.89e-03 | -1.38e-02 | 0.1055 |
29015 | SLC43A3 | P31T-E | Human | Esophagus | ESCC | 1.29e-16 | 4.36e-01 | 0.1251 |
29015 | SLC43A3 | P32T-E | Human | Esophagus | ESCC | 3.60e-03 | -2.48e-02 | 0.1666 |
29015 | SLC43A3 | P36T-E | Human | Esophagus | ESCC | 2.23e-05 | 4.66e-01 | 0.1187 |
29015 | SLC43A3 | P37T-E | Human | Esophagus | ESCC | 3.67e-11 | 4.46e-01 | 0.1371 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC43A3 | SNV | Missense_Mutation | novel | c.256N>G | p.Ile86Val | p.I86V | Q8NBI5 | protein_coding | tolerated(1) | benign(0.124) | TCGA-AC-A3EH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLC43A3 | SNV | Missense_Mutation | novel | c.1190C>T | p.Ser397Leu | p.S397L | Q8NBI5 | protein_coding | deleterious(0.01) | benign(0.124) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
SLC43A3 | SNV | Missense_Mutation | c.1123N>T | p.Leu375Phe | p.L375F | Q8NBI5 | protein_coding | deleterious(0) | possibly_damaging(0.876) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
SLC43A3 | SNV | Missense_Mutation | novel | c.912N>T | p.Leu304Phe | p.L304F | Q8NBI5 | protein_coding | deleterious(0) | probably_damaging(0.941) | TCGA-LL-A5YP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
SLC43A3 | deletion | Frame_Shift_Del | novel | c.615_652delNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNN | p.Ile206ProfsTer35 | p.I206Pfs*35 | Q8NBI5 | protein_coding | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC43A3 | deletion | Frame_Shift_Del | novel | c.1078delC | p.Gln360ArgfsTer25 | p.Q360Rfs*25 | Q8NBI5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
SLC43A3 | SNV | Missense_Mutation | rs137870474 | c.1177N>A | p.Ala393Thr | p.A393T | Q8NBI5 | protein_coding | deleterious(0.04) | benign(0.005) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC43A3 | SNV | Missense_Mutation | rs188327992 | c.647N>A | p.Arg216His | p.R216H | Q8NBI5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC43A3 | SNV | Missense_Mutation | novel | c.197N>A | p.Cys66Tyr | p.C66Y | Q8NBI5 | protein_coding | tolerated(0.35) | benign(0.051) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC43A3 | SNV | Missense_Mutation | c.595C>T | p.Leu199Phe | p.L199F | Q8NBI5 | protein_coding | deleterious(0.05) | benign(0.129) | TCGA-R2-A69V-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |