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Gene: SLC41A2 |
Gene summary for SLC41A2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SLC41A2 | Gene ID | 84102 |
| Gene name | solute carrier family 41 member 2 | |
| Gene Alias | SLC41A1-L1 | |
| Cytomap | 12q23.3 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q96JW4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 84102 | SLC41A2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.25e-30 | -8.51e-01 | 0.0155 |
| 84102 | SLC41A2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.79e-06 | -9.60e-01 | 0.0216 |
| 84102 | SLC41A2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.52e-07 | -6.34e-01 | -0.1207 |
| 84102 | SLC41A2 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.74e-14 | -5.53e-01 | -0.1464 |
| 84102 | SLC41A2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.23e-04 | -4.17e-01 | -0.1001 |
| 84102 | SLC41A2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.26e-06 | -4.95e-01 | -0.059 |
| 84102 | SLC41A2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.68e-04 | -6.84e-01 | -0.1706 |
| 84102 | SLC41A2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.44e-02 | -5.27e-01 | -0.0842 |
| 84102 | SLC41A2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.99e-02 | -4.52e-01 | -0.0179 |
| 84102 | SLC41A2 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.10e-24 | -7.77e-01 | 0.096 |
| 84102 | SLC41A2 | HTA11_9408_2000001011 | Human | Colorectum | AD | 9.76e-04 | -9.12e-01 | 0.0451 |
| 84102 | SLC41A2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.46e-05 | -7.47e-01 | 0.0528 |
| 84102 | SLC41A2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.73e-15 | -8.21e-01 | 0.0338 |
| 84102 | SLC41A2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.45e-28 | -8.17e-01 | 0.0674 |
| 84102 | SLC41A2 | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.34e-07 | -7.56e-01 | 0.0112 |
| 84102 | SLC41A2 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.58e-02 | -8.98e-01 | 0.0397 |
| 84102 | SLC41A2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.61e-08 | -6.95e-01 | 0.0588 |
| 84102 | SLC41A2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.29e-29 | -6.87e-01 | 0.294 |
| 84102 | SLC41A2 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.91e-08 | -5.85e-01 | 0.281 |
| 84102 | SLC41A2 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.24e-32 | -8.62e-01 | 0.3859 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:1903830 | Colorectum | FAP | magnesium ion transmembrane transport | 7/2622 | 17/18723 | 5.62e-03 | 3.61e-02 | 7 |
| GO:0015693 | Colorectum | FAP | magnesium ion transport | 7/2622 | 18/18723 | 8.10e-03 | 4.77e-02 | 7 |
| GO:19038301 | Colorectum | CRC | magnesium ion transmembrane transport | 7/2078 | 17/18723 | 1.46e-03 | 1.57e-02 | 7 |
| GO:00156931 | Colorectum | CRC | magnesium ion transport | 7/2078 | 18/18723 | 2.16e-03 | 2.11e-02 | 7 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SLC41A2 | SNV | Missense_Mutation | c.70N>A | p.Val24Ile | p.V24I | Q96JW4 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-AO-A0J8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | |
| SLC41A2 | SNV | Missense_Mutation | novel | c.1480N>G | p.His494Asp | p.H494D | Q96JW4 | protein_coding | deleterious(0.04) | possibly_damaging(0.871) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
| SLC41A2 | SNV | Missense_Mutation | novel | c.644N>T | p.Ala215Val | p.A215V | Q96JW4 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| SLC41A2 | SNV | Missense_Mutation | c.509N>T | p.Ala170Val | p.A170V | Q96JW4 | protein_coding | deleterious(0.04) | benign(0.153) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| SLC41A2 | SNV | Missense_Mutation | c.1183N>T | p.Gly395Cys | p.G395C | Q96JW4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SLC41A2 | SNV | Missense_Mutation | novel | c.1129N>A | p.Leu377Ile | p.L377I | Q96JW4 | protein_coding | deleterious(0.04) | benign(0.039) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SLC41A2 | SNV | Missense_Mutation | novel | c.329N>C | p.Asp110Ala | p.D110A | Q96JW4 | protein_coding | deleterious(0.04) | benign(0.398) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| SLC41A2 | SNV | Missense_Mutation | c.448A>G | p.Lys150Glu | p.K150E | Q96JW4 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-CM-6164-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SLC41A2 | SNV | Missense_Mutation | c.1519N>C | p.Phe507Leu | p.F507L | Q96JW4 | protein_coding | tolerated(0.98) | benign(0) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| SLC41A2 | SNV | Missense_Mutation | rs866165305 | c.1010N>T | p.Gly337Val | p.G337V | Q96JW4 | protein_coding | tolerated(0.5) | possibly_damaging(0.617) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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