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Gene: SLC38A6 |
Gene summary for SLC38A6 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SLC38A6 | Gene ID | 145389 |
| Gene name | solute carrier family 38 member 6 | |
| Gene Alias | NAT-1 | |
| Cytomap | 14q23.1 | |
| Gene Type | protein-coding | GO ID | GO:0003333 | UniProtAcc | Q8IZM9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 145389 | SLC38A6 | LZE4T | Human | Esophagus | ESCC | 9.61e-11 | 3.45e-01 | 0.0811 |
| 145389 | SLC38A6 | LZE5T | Human | Esophagus | ESCC | 1.63e-02 | 2.34e-01 | 0.0514 |
| 145389 | SLC38A6 | LZE8T | Human | Esophagus | ESCC | 4.53e-02 | 1.15e-01 | 0.067 |
| 145389 | SLC38A6 | LZE20T | Human | Esophagus | ESCC | 3.76e-02 | 1.47e-01 | 0.0662 |
| 145389 | SLC38A6 | LZE22T | Human | Esophagus | ESCC | 5.99e-04 | 3.71e-01 | 0.068 |
| 145389 | SLC38A6 | LZE24T | Human | Esophagus | ESCC | 7.01e-28 | 6.76e-01 | 0.0596 |
| 145389 | SLC38A6 | P2T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.20e-01 | 0.1177 |
| 145389 | SLC38A6 | P4T-E | Human | Esophagus | ESCC | 8.04e-15 | 1.72e-01 | 0.1323 |
| 145389 | SLC38A6 | P5T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.13e-01 | 0.1327 |
| 145389 | SLC38A6 | P8T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.31e-01 | 0.0889 |
| 145389 | SLC38A6 | P9T-E | Human | Esophagus | ESCC | 9.13e-10 | 1.84e-01 | 0.1131 |
| 145389 | SLC38A6 | P10T-E | Human | Esophagus | ESCC | 2.28e-35 | 5.26e-01 | 0.116 |
| 145389 | SLC38A6 | P11T-E | Human | Esophagus | ESCC | 6.32e-07 | 2.48e-01 | 0.1426 |
| 145389 | SLC38A6 | P12T-E | Human | Esophagus | ESCC | 1.77e-22 | 3.97e-01 | 0.1122 |
| 145389 | SLC38A6 | P15T-E | Human | Esophagus | ESCC | 3.20e-46 | 8.93e-01 | 0.1149 |
| 145389 | SLC38A6 | P16T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.79e-01 | 0.1153 |
| 145389 | SLC38A6 | P20T-E | Human | Esophagus | ESCC | 3.65e-17 | 2.56e-01 | 0.1124 |
| 145389 | SLC38A6 | P21T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.94e-01 | 0.1617 |
| 145389 | SLC38A6 | P22T-E | Human | Esophagus | ESCC | 5.00e-17 | 2.81e-01 | 0.1236 |
| 145389 | SLC38A6 | P23T-E | Human | Esophagus | ESCC | 4.77e-06 | 1.61e-01 | 0.108 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SLC38A6 | SNV | Missense_Mutation | c.359N>A | p.Gly120Glu | p.G120E | Q8IZM9 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
| SLC38A6 | SNV | Missense_Mutation | novel | c.850N>T | p.Val284Phe | p.V284F | Q8IZM9 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-LL-A440-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
| SLC38A6 | SNV | Missense_Mutation | novel | c.142G>C | p.Gly48Arg | p.G48R | Q8IZM9 | protein_coding | deleterious(0.01) | possibly_damaging(0.779) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| SLC38A6 | deletion | Frame_Shift_Del | c.634delN | p.Lys213AsnfsTer8 | p.K213Nfs*8 | Q8IZM9 | protein_coding | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
| SLC38A6 | SNV | Missense_Mutation | c.220N>A | p.Gly74Ser | p.G74S | Q8IZM9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
| SLC38A6 | SNV | Missense_Mutation | rs754906694 | c.260N>C | p.Leu87Pro | p.L87P | Q8IZM9 | protein_coding | deleterious(0) | possibly_damaging(0.648) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| SLC38A6 | SNV | Missense_Mutation | c.781C>T | p.Leu261Phe | p.L261F | Q8IZM9 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| SLC38A6 | SNV | Missense_Mutation | c.1066A>G | p.Thr356Ala | p.T356A | Q8IZM9 | protein_coding | tolerated(0.64) | benign(0.164) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| SLC38A6 | SNV | Missense_Mutation | novel | c.436N>A | p.Glu146Lys | p.E146K | Q8IZM9 | protein_coding | deleterious(0.01) | probably_damaging(0.986) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SLC38A6 | SNV | Missense_Mutation | novel | c.442C>A | p.Pro148Thr | p.P148T | Q8IZM9 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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