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Gene: SLC37A3 |
Gene summary for SLC37A3 |
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Gene information | Species | Human | Gene symbol | SLC37A3 | Gene ID | 84255 |
Gene name | solute carrier family 37 member 3 | |
Gene Alias | SPX3 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8NCC5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84255 | SLC37A3 | LZE4T | Human | Esophagus | ESCC | 2.78e-05 | 1.07e-02 | 0.0811 |
84255 | SLC37A3 | LZE7T | Human | Esophagus | ESCC | 3.00e-10 | 2.32e-01 | 0.0667 |
84255 | SLC37A3 | LZE20T | Human | Esophagus | ESCC | 3.50e-02 | -3.23e-02 | 0.0662 |
84255 | SLC37A3 | LZE24T | Human | Esophagus | ESCC | 2.67e-10 | 1.46e-01 | 0.0596 |
84255 | SLC37A3 | P1T-E | Human | Esophagus | ESCC | 2.84e-10 | 3.74e-01 | 0.0875 |
84255 | SLC37A3 | P2T-E | Human | Esophagus | ESCC | 8.70e-15 | 5.74e-02 | 0.1177 |
84255 | SLC37A3 | P4T-E | Human | Esophagus | ESCC | 8.17e-18 | 1.82e-01 | 0.1323 |
84255 | SLC37A3 | P5T-E | Human | Esophagus | ESCC | 9.05e-09 | 1.19e-01 | 0.1327 |
84255 | SLC37A3 | P8T-E | Human | Esophagus | ESCC | 7.72e-09 | 1.69e-01 | 0.0889 |
84255 | SLC37A3 | P9T-E | Human | Esophagus | ESCC | 6.84e-13 | 1.01e-01 | 0.1131 |
84255 | SLC37A3 | P10T-E | Human | Esophagus | ESCC | 1.63e-21 | 3.05e-01 | 0.116 |
84255 | SLC37A3 | P11T-E | Human | Esophagus | ESCC | 2.78e-11 | 1.29e-01 | 0.1426 |
84255 | SLC37A3 | P12T-E | Human | Esophagus | ESCC | 1.38e-26 | 5.14e-01 | 0.1122 |
84255 | SLC37A3 | P15T-E | Human | Esophagus | ESCC | 3.85e-18 | 4.90e-01 | 0.1149 |
84255 | SLC37A3 | P16T-E | Human | Esophagus | ESCC | 4.75e-18 | 4.14e-01 | 0.1153 |
84255 | SLC37A3 | P17T-E | Human | Esophagus | ESCC | 6.66e-04 | 5.94e-03 | 0.1278 |
84255 | SLC37A3 | P20T-E | Human | Esophagus | ESCC | 4.93e-08 | -4.37e-02 | 0.1124 |
84255 | SLC37A3 | P21T-E | Human | Esophagus | ESCC | 3.49e-12 | 2.49e-01 | 0.1617 |
84255 | SLC37A3 | P22T-E | Human | Esophagus | ESCC | 5.53e-08 | 3.41e-02 | 0.1236 |
84255 | SLC37A3 | P23T-E | Human | Esophagus | ESCC | 4.86e-09 | 5.54e-02 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC37A3 | insertion | Frame_Shift_Ins | novel | c.709_710insGCAACCTCTGCCTCCCGGGTTCAAGCGATTCTCCTGCCTCA | p.Ser237CysfsTer31 | p.S237Cfs*31 | Q8NCC5 | protein_coding | TCGA-A8-A09D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | ||
SLC37A3 | insertion | Frame_Shift_Ins | novel | c.905_906insTGTTGATGGATCAGTTCTTTTGTCTCGGGAA | p.Leu302PhefsTer28 | p.L302Ffs*28 | Q8NCC5 | protein_coding | TCGA-A8-A09W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
SLC37A3 | SNV | Missense_Mutation | rs780276041 | c.1070C>T | p.Ala357Val | p.A357V | Q8NCC5 | protein_coding | deleterious(0.01) | possibly_damaging(0.763) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC37A3 | SNV | Missense_Mutation | rs200437332 | c.95C>T | p.Ser32Leu | p.S32L | Q8NCC5 | protein_coding | deleterious(0.01) | benign(0.153) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC37A3 | SNV | Missense_Mutation | c.772N>A | p.Glu258Lys | p.E258K | Q8NCC5 | protein_coding | tolerated(0.09) | benign(0.047) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC37A3 | SNV | Missense_Mutation | c.796N>C | p.Asn266His | p.N266H | Q8NCC5 | protein_coding | tolerated(0.06) | possibly_damaging(0.549) | TCGA-Q1-A5R1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC37A3 | SNV | Missense_Mutation | c.521N>A | p.Gly174Glu | p.G174E | Q8NCC5 | protein_coding | deleterious(0.01) | benign(0.159) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SLC37A3 | SNV | Missense_Mutation | c.191N>T | p.Pro64Leu | p.P64L | Q8NCC5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SLC37A3 | SNV | Missense_Mutation | rs780276041 | c.1070C>T | p.Ala357Val | p.A357V | Q8NCC5 | protein_coding | deleterious(0.01) | possibly_damaging(0.763) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC37A3 | SNV | Missense_Mutation | novel | c.70T>C | p.Phe24Leu | p.F24L | Q8NCC5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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