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Gene: SLC37A1 |
Gene summary for SLC37A1 |
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Gene information | Species | Human | Gene symbol | SLC37A1 | Gene ID | 54020 |
Gene name | solute carrier family 37 member 1 | |
Gene Alias | G3PP | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | P57057 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54020 | SLC37A1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.44e-02 | 2.75e-01 | -0.1954 |
54020 | SLC37A1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.78e-05 | 9.60e-01 | -0.2602 |
54020 | SLC37A1 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.10e-02 | 3.70e-01 | -0.1464 |
54020 | SLC37A1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.69e-05 | 5.73e-01 | -0.059 |
54020 | SLC37A1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.13e-02 | 8.19e-01 | 0.3487 |
54020 | SLC37A1 | A001-C-207 | Human | Colorectum | FAP | 4.17e-02 | -1.86e-01 | 0.1278 |
54020 | SLC37A1 | A015-C-203 | Human | Colorectum | FAP | 1.81e-25 | -4.13e-01 | -0.1294 |
54020 | SLC37A1 | A015-C-204 | Human | Colorectum | FAP | 1.26e-05 | -3.53e-01 | -0.0228 |
54020 | SLC37A1 | A014-C-040 | Human | Colorectum | FAP | 9.28e-03 | -3.66e-01 | -0.1184 |
54020 | SLC37A1 | A002-C-201 | Human | Colorectum | FAP | 4.27e-07 | -9.08e-02 | 0.0324 |
54020 | SLC37A1 | A002-C-203 | Human | Colorectum | FAP | 9.31e-03 | -2.46e-02 | 0.2786 |
54020 | SLC37A1 | A001-C-119 | Human | Colorectum | FAP | 6.03e-06 | -4.24e-01 | -0.1557 |
54020 | SLC37A1 | A001-C-108 | Human | Colorectum | FAP | 5.86e-17 | -3.52e-01 | -0.0272 |
54020 | SLC37A1 | A002-C-205 | Human | Colorectum | FAP | 8.54e-20 | -4.26e-01 | -0.1236 |
54020 | SLC37A1 | A001-C-104 | Human | Colorectum | FAP | 6.89e-08 | -2.91e-01 | 0.0184 |
54020 | SLC37A1 | A015-C-006 | Human | Colorectum | FAP | 2.25e-12 | -4.01e-01 | -0.0994 |
54020 | SLC37A1 | A015-C-106 | Human | Colorectum | FAP | 2.46e-12 | -3.21e-01 | -0.0511 |
54020 | SLC37A1 | A002-C-114 | Human | Colorectum | FAP | 5.54e-17 | -4.93e-01 | -0.1561 |
54020 | SLC37A1 | A015-C-104 | Human | Colorectum | FAP | 1.66e-30 | -4.91e-01 | -0.1899 |
54020 | SLC37A1 | A001-C-014 | Human | Colorectum | FAP | 4.61e-12 | -3.19e-01 | 0.0135 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0015698 | Colorectum | AD | inorganic anion transport | 52/3918 | 180/18723 | 6.83e-03 | 4.22e-02 | 52 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00156981 | Colorectum | FAP | inorganic anion transport | 38/2622 | 180/18723 | 5.73e-03 | 3.67e-02 | 38 |
GO:1901264 | Liver | HCC | carbohydrate derivative transport | 48/7958 | 80/18723 | 1.19e-03 | 6.62e-03 | 48 |
GO:0008643 | Liver | HCC | carbohydrate transport | 80/7958 | 152/18723 | 7.34e-03 | 2.92e-02 | 80 |
GO:0006817 | Lung | IAC | phosphate ion transport | 8/2061 | 24/18723 | 3.09e-03 | 2.71e-02 | 8 |
GO:00157482 | Lung | IAC | organophosphate ester transport | 26/2061 | 140/18723 | 5.22e-03 | 3.97e-02 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC37A1 | SNV | Missense_Mutation | novel | c.1084N>T | p.Ala362Ser | p.A362S | P57057 | protein_coding | tolerated(0.18) | benign(0.026) | TCGA-A1-A0SO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | SD | |
SLC37A1 | SNV | Missense_Mutation | novel | c.360N>G | p.Ile120Met | p.I120M | P57057 | protein_coding | deleterious(0.01) | benign(0.278) | TCGA-A2-A1G6-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
SLC37A1 | SNV | Missense_Mutation | novel | c.1394C>T | p.Thr465Met | p.T465M | P57057 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SLC37A1 | SNV | Missense_Mutation | c.389T>C | p.Leu130Pro | p.L130P | P57057 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC37A1 | SNV | Missense_Mutation | c.461N>A | p.Ser154Asn | p.S154N | P57057 | protein_coding | tolerated(0.4) | benign(0.013) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC37A1 | insertion | Nonsense_Mutation | novel | c.687_688insTCTGGCTGTCGTGCCCCCTGCTTTGTGTAA | p.Ile229_Val230insSerGlyCysArgAlaProCysPheValTer | p.I229_V230insSGCRAPCFV* | P57057 | protein_coding | TCGA-A2-A0D2-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
SLC37A1 | deletion | In_Frame_Del | novel | c.93_116delNNNNNNNNNNNNNNNNNNNNNNNN | p.Tyr32_Arg39del | p.Y32_R39del | P57057 | protein_coding | TCGA-B6-A0RS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
SLC37A1 | SNV | Missense_Mutation | novel | c.62G>A | p.Arg21Lys | p.R21K | P57057 | protein_coding | tolerated(0.28) | benign(0.173) | TCGA-C5-A8XH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SLC37A1 | SNV | Missense_Mutation | c.433N>C | p.Gly145Arg | p.G145R | P57057 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-EK-A2R7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC37A1 | insertion | Nonsense_Mutation | novel | c.1200_1201insTGAGAGT | p.Leu401Ter | p.L401* | P57057 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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