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Gene: SLC35F2 |
Gene summary for SLC35F2 |
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Gene information | Species | Human | Gene symbol | SLC35F2 | Gene ID | 54733 |
Gene name | solute carrier family 35 member F2 | |
Gene Alias | HSNOV1 | |
Cytomap | 11q22.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8IXU6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54733 | SLC35F2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.85e-72 | 1.75e+00 | 0.0155 |
54733 | SLC35F2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.41e-32 | 1.56e+00 | -0.1808 |
54733 | SLC35F2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.10e-20 | 1.89e+00 | 0.0216 |
54733 | SLC35F2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.00e-35 | 1.76e+00 | -0.0811 |
54733 | SLC35F2 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.53e-16 | 6.97e-01 | -0.1088 |
54733 | SLC35F2 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.01e-52 | 1.75e+00 | -0.1954 |
54733 | SLC35F2 | HTA11_411_2000001011 | Human | Colorectum | SER | 8.21e-21 | 2.13e+00 | -0.2602 |
54733 | SLC35F2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.90e-11 | 1.48e+00 | -0.2196 |
54733 | SLC35F2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.57e-30 | 1.91e+00 | -0.1207 |
54733 | SLC35F2 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.80e-30 | 1.53e+00 | -0.1526 |
54733 | SLC35F2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.51e-58 | 1.75e+00 | -0.1464 |
54733 | SLC35F2 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.76e-43 | 1.52e+00 | -0.1001 |
54733 | SLC35F2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.47e-51 | 1.96e+00 | -0.059 |
54733 | SLC35F2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.72e-23 | 1.85e+00 | -0.1706 |
54733 | SLC35F2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.33e-12 | 1.13e+00 | -0.2061 |
54733 | SLC35F2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 9.55e-28 | 2.12e+00 | -0.1462 |
54733 | SLC35F2 | HTA11_546_2000001011 | Human | Colorectum | AD | 6.55e-28 | 1.99e+00 | -0.0842 |
54733 | SLC35F2 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.07e-18 | 1.64e+00 | -0.00410000000000005 |
54733 | SLC35F2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.17e-18 | 1.13e+00 | -0.0179 |
54733 | SLC35F2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.29e-58 | 1.84e+00 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35F2 | SNV | Missense_Mutation | novel | c.678N>T | p.Gln226His | p.Q226H | Q8IXU6 | protein_coding | deleterious(0.02) | possibly_damaging(0.617) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC35F2 | SNV | Missense_Mutation | novel | c.447N>A | p.Met149Ile | p.M149I | Q8IXU6 | protein_coding | tolerated(0.3) | benign(0.326) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC35F2 | SNV | Missense_Mutation | c.209N>G | p.Asn70Ser | p.N70S | Q8IXU6 | protein_coding | tolerated(0.1) | possibly_damaging(0.792) | TCGA-AZ-6606-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfiri | PD | |
SLC35F2 | SNV | Missense_Mutation | rs759829169 | c.281N>A | p.Arg94Gln | p.R94Q | Q8IXU6 | protein_coding | tolerated(0.13) | benign(0.104) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC35F2 | SNV | Missense_Mutation | c.98N>C | p.Lys33Thr | p.K33T | Q8IXU6 | protein_coding | tolerated(0.13) | benign(0.254) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC35F2 | SNV | Missense_Mutation | novel | c.865N>G | p.Thr289Ala | p.T289A | Q8IXU6 | protein_coding | tolerated(0.09) | probably_damaging(0.999) | TCGA-AJ-A8CW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35F2 | SNV | Missense_Mutation | rs201723525 | c.1039N>A | p.Val347Met | p.V347M | Q8IXU6 | protein_coding | tolerated(0.06) | benign(0.115) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC35F2 | SNV | Missense_Mutation | c.145N>G | p.Leu49Val | p.L49V | Q8IXU6 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC35F2 | SNV | Missense_Mutation | novel | c.672N>A | p.Ser224Arg | p.S224R | Q8IXU6 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
SLC35F2 | SNV | Missense_Mutation | novel | c.565N>A | p.Asp189Asn | p.D189N | Q8IXU6 | protein_coding | tolerated(0.3) | benign(0.02) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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