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Gene: SLC35F1 |
Gene summary for SLC35F1 |
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Gene information | Species | Human | Gene symbol | SLC35F1 | Gene ID | 222553 |
Gene name | solute carrier family 35 member F1 | |
Gene Alias | C6orf169 | |
Cytomap | 6q22.2-q22.31 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5T1Q4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222553 | SLC35F1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.16e-33 | 5.81e-01 | 0.0155 |
222553 | SLC35F1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.21e-16 | 5.33e-01 | -0.1808 |
222553 | SLC35F1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.92e-35 | 2.03e+00 | 0.0216 |
222553 | SLC35F1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.20e-29 | 1.04e+00 | -0.0811 |
222553 | SLC35F1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.34e-08 | 2.69e-01 | -0.1088 |
222553 | SLC35F1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.16e-66 | 1.83e+00 | -0.1954 |
222553 | SLC35F1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.99e-17 | 1.19e+00 | -0.2602 |
222553 | SLC35F1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.90e-17 | 1.20e+00 | -0.2196 |
222553 | SLC35F1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.35e-28 | 8.93e-01 | -0.1207 |
222553 | SLC35F1 | HTA11_83_2000001011 | Human | Colorectum | SER | 6.93e-24 | 7.72e-01 | -0.1526 |
222553 | SLC35F1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.60e-65 | 1.10e+00 | -0.1464 |
222553 | SLC35F1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.72e-65 | 9.99e-01 | -0.1001 |
222553 | SLC35F1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.79e-55 | 1.42e+00 | -0.059 |
222553 | SLC35F1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.91e-20 | 1.09e+00 | -0.1706 |
222553 | SLC35F1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.86e-03 | 3.94e-01 | -0.2061 |
222553 | SLC35F1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.07e-22 | 1.15e+00 | -0.1462 |
222553 | SLC35F1 | HTA11_546_2000001011 | Human | Colorectum | AD | 7.20e-24 | 8.81e-01 | -0.0842 |
222553 | SLC35F1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 7.39e-06 | 5.61e-01 | -0.00410000000000005 |
222553 | SLC35F1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.15e-59 | 2.30e+00 | -0.0179 |
222553 | SLC35F1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.51e-55 | 1.14e+00 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC35F1 | SNV | Missense_Mutation | rs746533334 | c.604G>A | p.Ala202Thr | p.A202T | Q5T1Q4 | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-A2-A4S3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35F1 | SNV | Missense_Mutation | c.370A>C | p.Ile124Leu | p.I124L | Q5T1Q4 | protein_coding | deleterious(0) | benign(0.075) | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SLC35F1 | SNV | Missense_Mutation | novel | c.756N>A | p.Met252Ile | p.M252I | Q5T1Q4 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC35F1 | SNV | Missense_Mutation | novel | c.1060N>A | p.Ser354Thr | p.S354T | Q5T1Q4 | protein_coding | tolerated(0.49) | possibly_damaging(0.464) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC35F1 | insertion | Frame_Shift_Ins | novel | c.774_775insT | p.Ser261GlnfsTer11 | p.S261Qfs*11 | Q5T1Q4 | protein_coding | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC35F1 | SNV | Missense_Mutation | novel | c.775T>G | p.Phe259Val | p.F259V | Q5T1Q4 | protein_coding | tolerated(0.3) | benign(0.241) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC35F1 | SNV | Missense_Mutation | c.848N>A | p.Gly283Glu | p.G283E | Q5T1Q4 | protein_coding | tolerated(0.14) | probably_damaging(0.969) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
SLC35F1 | SNV | Missense_Mutation | c.1012N>A | p.Leu338Ile | p.L338I | Q5T1Q4 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SLC35F1 | SNV | Missense_Mutation | c.725N>A | p.Arg242Gln | p.R242Q | Q5T1Q4 | protein_coding | deleterious(0) | possibly_damaging(0.523) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SLC35F1 | SNV | Missense_Mutation | c.1155N>T | p.Gln385His | p.Q385H | Q5T1Q4 | protein_coding | tolerated(0.06) | benign(0.003) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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