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Gene: SLC31A2 |
Gene summary for SLC31A2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | SLC31A2 | Gene ID | 1318 |
| Gene name | solute carrier family 31 member 2 | |
| Gene Alias | COPT2 | |
| Cytomap | 9q32 | |
| Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | O15432 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1318 | SLC31A2 | LZE4T | Human | Esophagus | ESCC | 1.23e-07 | 2.37e-01 | 0.0811 |
| 1318 | SLC31A2 | LZE20T | Human | Esophagus | ESCC | 1.71e-02 | 9.91e-02 | 0.0662 |
| 1318 | SLC31A2 | LZE24T | Human | Esophagus | ESCC | 6.89e-05 | 1.14e-01 | 0.0596 |
| 1318 | SLC31A2 | P2T-E | Human | Esophagus | ESCC | 5.43e-22 | 3.90e-01 | 0.1177 |
| 1318 | SLC31A2 | P4T-E | Human | Esophagus | ESCC | 3.47e-02 | 7.25e-02 | 0.1323 |
| 1318 | SLC31A2 | P5T-E | Human | Esophagus | ESCC | 1.70e-41 | 7.41e-01 | 0.1327 |
| 1318 | SLC31A2 | P8T-E | Human | Esophagus | ESCC | 2.68e-03 | 1.23e-01 | 0.0889 |
| 1318 | SLC31A2 | P10T-E | Human | Esophagus | ESCC | 4.63e-41 | 6.87e-01 | 0.116 |
| 1318 | SLC31A2 | P11T-E | Human | Esophagus | ESCC | 2.79e-13 | 7.25e-01 | 0.1426 |
| 1318 | SLC31A2 | P12T-E | Human | Esophagus | ESCC | 5.24e-08 | 2.04e-01 | 0.1122 |
| 1318 | SLC31A2 | P15T-E | Human | Esophagus | ESCC | 7.27e-10 | 1.71e-01 | 0.1149 |
| 1318 | SLC31A2 | P16T-E | Human | Esophagus | ESCC | 1.62e-04 | 6.84e-02 | 0.1153 |
| 1318 | SLC31A2 | P17T-E | Human | Esophagus | ESCC | 1.58e-03 | 2.57e-01 | 0.1278 |
| 1318 | SLC31A2 | P20T-E | Human | Esophagus | ESCC | 2.77e-05 | 7.79e-02 | 0.1124 |
| 1318 | SLC31A2 | P21T-E | Human | Esophagus | ESCC | 1.44e-45 | 1.02e+00 | 0.1617 |
| 1318 | SLC31A2 | P22T-E | Human | Esophagus | ESCC | 1.48e-03 | 7.22e-02 | 0.1236 |
| 1318 | SLC31A2 | P24T-E | Human | Esophagus | ESCC | 1.09e-13 | 2.92e-01 | 0.1287 |
| 1318 | SLC31A2 | P26T-E | Human | Esophagus | ESCC | 8.29e-08 | 1.35e-01 | 0.1276 |
| 1318 | SLC31A2 | P27T-E | Human | Esophagus | ESCC | 1.34e-02 | 8.49e-02 | 0.1055 |
| 1318 | SLC31A2 | P28T-E | Human | Esophagus | ESCC | 5.90e-03 | 4.50e-02 | 0.1149 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:005507617 | Esophagus | ESCC | transition metal ion homeostasis | 87/8552 | 138/18723 | 2.85e-05 | 2.37e-04 | 87 |
| GO:00469169 | Esophagus | ESCC | cellular transition metal ion homeostasis | 70/8552 | 115/18723 | 7.28e-04 | 3.79e-03 | 70 |
| GO:00550703 | Esophagus | ESCC | copper ion homeostasis | 15/8552 | 18/18723 | 1.20e-03 | 5.88e-03 | 15 |
| GO:00068781 | Esophagus | ESCC | cellular copper ion homeostasis | 12/8552 | 15/18723 | 7.31e-03 | 2.63e-02 | 12 |
| GO:005507610 | Oral cavity | OSCC | transition metal ion homeostasis | 81/7305 | 138/18723 | 2.13e-06 | 2.72e-05 | 81 |
| GO:00469168 | Oral cavity | OSCC | cellular transition metal ion homeostasis | 64/7305 | 115/18723 | 2.13e-04 | 1.40e-03 | 64 |
| GO:00550702 | Oral cavity | OSCC | copper ion homeostasis | 14/7305 | 18/18723 | 9.51e-04 | 4.96e-03 | 14 |
| GO:0006878 | Oral cavity | OSCC | cellular copper ion homeostasis | 11/7305 | 15/18723 | 7.49e-03 | 2.75e-02 | 11 |
| GO:005507618 | Skin | cSCC | transition metal ion homeostasis | 57/4864 | 138/18723 | 5.96e-05 | 5.86e-04 | 57 |
| GO:004691610 | Skin | cSCC | cellular transition metal ion homeostasis | 48/4864 | 115/18723 | 1.63e-04 | 1.43e-03 | 48 |
| GO:00550704 | Skin | cSCC | copper ion homeostasis | 12/4864 | 18/18723 | 3.39e-04 | 2.68e-03 | 12 |
| GO:00068782 | Skin | cSCC | cellular copper ion homeostasis | 10/4864 | 15/18723 | 1.10e-03 | 7.24e-03 | 10 |
| GO:005507632 | Thyroid | ATC | transition metal ion homeostasis | 66/6293 | 138/18723 | 3.64e-04 | 2.25e-03 | 66 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| SLC31A2 | SNV | Missense_Mutation | novel | c.389N>T | p.Ala130Val | p.A130V | O15432 | protein_coding | tolerated(0.22) | benign(0.281) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| SLC31A2 | SNV | Missense_Mutation | novel | c.89T>C | p.Val30Ala | p.V30A | O15432 | protein_coding | deleterious(0.02) | probably_damaging(0.932) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| SLC31A2 | SNV | Missense_Mutation | c.215N>T | p.Gly72Val | p.G72V | O15432 | protein_coding | tolerated(0.28) | benign(0.096) | TCGA-D1-A15X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| SLC31A2 | SNV | Missense_Mutation | novel | c.221C>A | p.Ser74Tyr | p.S74Y | O15432 | protein_coding | deleterious(0.01) | probably_damaging(0.989) | TCGA-DJ-A2QB-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| SLC31A2 | SNV | Missense_Mutation | novel | c.207N>C | p.Glu69Asp | p.E69D | O15432 | protein_coding | tolerated(0.17) | benign(0.01) | TCGA-ET-A2N3-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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